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Gi Stool Panel Text Questions


bekkaz

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bekkaz Apprentice

I have recently went to a functional medicine Dr. who is also a certified clinical nutritionist, due to having several health issues. I have had chronic female issues, PH Levels off, Bacterial Vaginosis, Yeast, Years of Constipation, Little cysts popping up here and there, sinus infections, anxiety, depression, fatigue, irritability, bloating, bladder pain (thinking about texting me for IC). Anyway after jumping from quack quack Dr. to quack quack Dr. and not giving up...I found an article that pointed me to a site for a Dr. in CA. This Dr. co-wrote the book "The Gluten Effect", I called this Dr. I live in WI. She said she felt she could help me but I need to come to CA, which I couldn't do. So, I found a Dr. like herself in my area. My first appt. was at the beginning of Aug. they decided to run a complete GI stool sample profile on me (sent to a lab, metametrix) that goes right down to the DNA. I got my results back this past Friday. It showed a substantial fungal overgrowth, a low level of PH (meaning to much acid in my system) I am not breaking down fats. On this GI panel is a text for your reaction to fecal sIgA and Anti-gliadin sIgA which I came back in the 65-70% positive range for. Has anyone used this type of test to determine gluten intolerance? I meet with the Dr. to discuss results this Wed. I know they will pull me off of gluten, among several other things for at least 6 weeks. My question I am wondering is am I intolerant and will I be most likely pulled off forever, or just while I heal? It's been a while since I read the "gluten effect" book but if I recalled from that book, I would be considered intolerant forever?!?


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    • Scott Adams
      I will assume you did the gluten challenge properly and were eating a lot of gluten daily for 6-8 weeks before your test, but if not, that could be the issue. You can still have celiac disease with negative blood test results, although it's not as common:  Clinical and genetic profile of patients with seronegative coeliac disease: the natural history and response to gluten-free diet: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606118/  Seronegative Celiac Disease - A Challenging Case: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441776/  Enteropathies with villous atrophy but negative coeliac serology in adults: current issues: https://pubmed.ncbi.nlm.nih.gov/34764141/  Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS.
    • Xravith
      I'm very confused... My blood test came out negative, I checked all antibodies. I suppose my Total IgA levels are normal (132 mg/dl), so the test should be reliable. Still, I'm not relieved as I can't tolerate even a single biscuit. I need to talk to my doctor about whether a duodenal biopsy is necessary. But it is really possible to have intestinal damage despite having a seronegative results? I have really strong symptoms, and I don't want to keep skipping university lectures or being bedridden at home.
    • Scott Adams
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    • Scott Adams
      In the Europe the new protocol for making a celiac disease diagnosis in children is if their tTg-IgA (tissue transglutaminase IgA) levels are 10 times or above the positive level for celiac disease--and you are above that level. According to the latest research, if the blood test results are at certain high levels that range between 5-10 times the reference range for a positive celiac disease diagnosis, it may not be necessary to confirm the results using an endoscopy/biopsy: Blood Test Alone Can Diagnose Celiac Disease in Most Children and Adults TGA-IgA at or Above Five Times Normal Limit in Kids Indicates Celiac Disease in Nearly All Cases No More Biopsies to Diagnose Celiac Disease in Children! May I ask why you've had so many past tTg-IgA tests done, and many of them seem to have been done 3 times during short time intervals?    
    • trents
      @JettaGirl, "Coeliac" is the British spelling of "celiac". Same disease. 
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