gameboy68

I am taking 1000 mcg of B12 each morning @trents. I also eat a lot of B12 in my diet which is why I was surprised it was so low. My OBGYN (who ordered the test) said that most of her patients are at 900+ for B12, which also shocked me! I have not been tested for iron deficiency/anemia, but I will look into that.

@plumbago Thanks again! I do not take any NSAIDs. I appreciate your advice, and I will follow up re. sodium with my provider. 

Thank you for your insight @plumbago @trents !

I am taking supplements for B12 and D3 now, but after retest, I am still low. I am hoping to be approved for B12 shots soon. My Neurologist mentioned that the B12 deficiency could be due to malabsorption and thought that the supplements would not work because of it; she said that is a common issue with Celiac. I have tested low on sodium a few times before (132 and 133), but my doctor hasn't addressed it nor my potassium being low. 

As for the gluten challenge, I definitely was not eating as much gluten as @trents listed each day. I was hesitant to do the challenge at all because my GI said that I did not need to/it did not matter, so I did it more minimally. 

I am not sure where to go from here in terms of testing/diagnosis. If anyone has been in a similar situation/has advice, I would appreciate it. Thanks!

Thank you! 

Below are the reference ranges for my lab:

• Gliadin Ab, IgG and IgA: Reference Range = below <20 Units | My value: 4
• Transglutaminase IgA, IgG Abs: Reference Range = below <4 U/ml | My value: <2
• IgA: Reference Range = 70-400 | My value: 174

• Vitamin D 25 Hydroxy: Reference Range = 31-80 | My value: 22.6
• Vitamin B12: Reference Range = 232-1245 | My value: 195
• AST: Reference Range = 13-35 U/L | My value: 10
• ALT: Reference Range = 7-38 U/L | My Value: 6
• Sodium: Reference Range = 136-144 mmol/L | My value: 130
• Potassium: Reference Range = 3.7-5.1 mmol/L | My value: 3.5
• CO2: Reference Range = 22-30 mmol/L | My value: 20
• MCV: Reference Range = 80-100 | My value: 79

Hi Folx,

I have had GI issues for a while, but more recently (~2 yr), I’ve had increased issues in response to gluten- it’s gotten to the point where I’m not comfortable driving after gluten because of how exhausted and brain fogged I get. 

Some symptoms I have when i eat gluten are: 

-severe, painful bloating (stomach is very bloated but hard and pain feels like it is sharp and ripping from the center)

-diarrhea/constipation/vomiting

-rashes

-facial flushing

-extreme fatigue & brain fog

- nausea

-joint/bone pain

-it can also trigger my migraines

2 months ago I had an endoscopy and colonoscopy for other reasons. I was almost completely (at most gluten 1x/week) in the months leading up to it. I was also still on my PPI until the day before (which I know can cloud results) per the prep instructions. The GI I’m seeing isn’t the best [forgot to check for what he did the procedure for (after 6+ months of waiting for a slot)].

 GI took a biopsy of my duodenum which showed “Small bowel mucosa with increased intraepithelial lymphocytes”. The notes about it say “intact villous architecture with increased intraepithelial lymphocytes has a broad differential which includes partially treated/clinically latent celiac disease, infectious etiologies, NSAID or other medication-type injuries, collagen vascular disease, inflammatory bowel disease, and a variety of allergic-type/immune disorders as well as non-specific lymphocytic enteritis.” I also had mild chronic gastritis in my stomach. 

Doc ordered 3 blood tests. He told me it didn’t matter if I ate gluten before the tests, but I tried to do a gluten challenge 5 weeks before (having one meal w gluten at night). Results were: 
1. Gliadin Ab, IgG and IgA: 4 
2. Transglutaminase IgA, IgG Abs: <2
3. IgA: 174

Not sure if relevant, but here are some other blood tests I recently had:
1. Vitamin D 25 Hydroxy: 22.6
2. Vitamin B12: 195
3. AST/ALT: 10/6
4. Sodium: 130
5. Potassium: 3.5
6. CO2: 20
7. MCV: 79

TLDR: Biopsy indicated potential partially treated celiac (while on gluten-free free diet), serology was negative.

I am planning to continue a gluten-free free diet regardless for comfort, but I’m wondering if it is still possible for it to be celiac/if anyone else has had a similar experience/if I should be looking into something else. Thanks.