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Histological Studies of Small-Intestinal Biopsies from Infants with Low Rate of Weight Gain

AU- Fallstrom SP; Kristiansson B; Ryd W
JN- Acta Pathol Microbiol Scand [A]; 89 (6) p431-8
PY- Nov 1981

AB- Eighty-one children aged 4-18 months with unsatisfactory weight gain were investigated for organic diseases; the investigation included small-intestinal biopsy. Sixteen had total villous atrophy, in most cases due to gluten intolerance. Transient disease, e.g. cows milk protein intolerance, was

probable in 7 children with subtotal atrophy. In 18 children the only abnormal finding was an increased number of inflammatory cells in the mucosa, a finding which was probably of no clinical significance. Planimetric measurement showed good agreement between the mucosal surface/volume ratio and an ordinary histological grouping of the mucosa. A significant correlation was found between the rate of weight gain during the period preceding investigation and mucosal surface/volume ratio.

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