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Large Number of Irritable Bowel Syndrome Patients Sensitive to Gluten

Celiac.com 07/29/2015 - Numerous studies have shown that a high percentage of patients with irritable bowel syndrome (IBS) are also sensitive to gluten. 

Photo: CC--Nana B. AgyeiA team of researchers recently set out to evaluate the effect of a gluten-free diet on gastrointestinal symptoms in patients with IBS. The research team included B. Shahbazkhani, A. Sadeghi, R. Malekzadeh, F. Khatavi, M. Etemadi, E. Kalantri, M. Rostami-Nejad, and K. Rostami.

They are variously affiliated with the Gastroenterology Unit of Imam Khomeini Hospital at the Tehran University of Medical Sciences, Tehran, Iran, the Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Shariati Hospital, Tehran, Iran, the Sasan Alborz Biomedical Research Center, Masoud Gastroenterology and Hepatology Clinic, Tehran, Iran, the Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran, the Gholhak Medical Laboratory, Tehran, Iran, the Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran, and with the Department of Gastroenterology, Alexandra Hospital, Worcestershire, UK.

For their double-blind randomized, placebo-controlled trial, the team enrolled 148 IBS patients who fulfilled Rome III criteria between 2011 and 2013.

Unfortunately, only 72 out of the 148 remained on a gluten-free diet for the six weeks needed to complete the study.

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The team recorded clinical symptoms biweekly using a standard visual analogue scale (VAS).

In the second stage after six weeks, patients whose symptoms improved to an acceptable level were randomly divided into two groups; The first group of 35 patients received packages containing powdered gluten, while 37 patients received a gluten-free placebo powder.

Nearly 84% of the gluten-free placebo group showed a significant improvement in symptoms compared to just under 26% for the gluten consuming group (p < 0.001).

This study confirms that a large number of patients diagnosed with irritable bowel syndrome are sensitive to gluten.

The team suggests that the term of IBS might be misleading and may change or delay an "effective and well-targeted treatment strategy in gluten sensitive patients."

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4 Responses:

 
jan
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
30 Jul 2015 3:03:21 AM PDT
Excellent.

 
Glinda
Rating: ratingfullratingfullratingfullratingemptyratingempty Unrated
said this on
03 Aug 2015 9:02:03 AM PDT
Really? This is news? IBS is doctor's code for I Be Stumped, and I won't be digging any deeper to try to help you figure out the cause. Now take this hyoscyamine and deal.
I'm an RN with celiac disease and have a son with celiac disease...any time I have a patient who has GI symptoms and autoimmune disease, I always insist on testing for celiac disease. And the funniest thing is that when I start to ask about family history, it almost always pops up that one family member has celiac or gluten intolerance but none of the extended family was ever tested. Still a huge lack of understanding and awareness in the medical community.

 
Debbie
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
04 Aug 2015 6:54:33 AM PDT
I went gluten free after figuring it out for myself. I'm an RN as well. Refused to go back on gluten to have a test tell me what I already found out! Husband has had IBS his whole life. Got amazingly better on the GF diet and suffered horribly when visiting relatives and ate what he wanted! Proof Positive... no further testing needed!!

 
ann93
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said this on
19 Aug 2015 11:31:16 PM PDT
Thanks for article! I also have IBS-C for five years and it is very hard to deal with this condition.




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The only symptom I know of that is celiac for certain is dh, which must be diagnosed by a dermatologist.

I have both eoe and celiac and now that I have been gluten free for 18 months, my anemia is gone. It is good to get off the iron supliments because mine may have been the cause of my ulcers. It feels good to recover and heal! I may work my way down to fewer supliments and lots of feel great da...

Your daughter does not have a strong positive. I suspect that the GI might do as RMJ suggested which would be to load her up on gluten for six months and retest. On the other hand, with a diagnosed sibling and a very mild positive, your GI might recommend the endoscopy or run the test again to ...

I was diagnosed with celiac last year on an endoscopy looking for the cause of my anemia. At the time, my GI doc tested m for EoE and it was negative. Fast forward 11 months, I developed sudden heart burn, dysphagia out of the blue. My doc thinks it's EoE. Biopsy was last week and I am still wait...

No, the control test is to verify that she will react to that particular type of test. If she didn't, then certain of the bloods would not be applicable to her. They would be false negatives. As far as tests being weak positives, that's like being a little pregnant. A positive is a positive....