See who reacted to this (24760) - Current Clinical Celiac Disease Trials at the Mayo Clinic

Welcome to Celiac.com!

You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.
Celiac.com Sponsor (A1):

Celiac.com Sponsor (A1-M):
Get Celiac.com Updates:

Support Our Content

eNewsletter

Donate
- All (1)
- Like (1)
- Thanks (0)
- Haha (0)
- Confused (0)
- Sad (0)
- Upvote (0)
1. Dax
  March 12, 2024
Get Celiac.com Updates:

Support Celiac.com:

Join eNewsletter

Donate
About Me

Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

>VIEW ALL ARTICLES BY JEFFERSON ADAMS
Celiac.com Sponsor (A17):

Celiac.com Sponsor (A17):

Celiac.com Sponsors (A17-M):
Related Articles
Celiac Vaccine Clears First Big Clinical Trial
Celiac.com 04/03/2017 - Massachusetts biotech firm ImmusanT has announced the successful completion of its first phase 1b trial of Nexvax2, an immunotherapy drug designed to protect celiac sufferers from the adverse effects of gluten exposure, including gastrointestinal symptoms, such as diarrhea, abdominal pain and bloating.
Nexvax2 is a drug that relies on three peptides designed to promote T cells involved in the inflammatory reaction in celiac disease to become tolerant to gluten. The company hopes that an initial course will promote gluten-tolerance, which can then be maintained by periodic boosters of the vaccine.
The phase 1b trial in 38 patients showed no issues with safety or tolerability, and indicated that the immunotherapy seemed to work as designed. The study also helped ...

Read Full Article...

19 comments

231,382 views
Promising Celiac Vaccine Nexvax2 Begins Phase Two Trials
Celiac.com 11/05/2018 - ImmusanT, Inc. is a clinical stage company looking to deliver innovative peptide-based immunomodulatory vaccine therapies to patients with autoimmune diseases, initiated enrollment in Australia and New Zealand for its celiac disease vaccine. Along with Nexvax2, ImmusanT is working to develop vaccines for other HLA-associated autoimmune diseases, including type 1 diabetes.
The Phase 2 trials will assess the safety, tolerability and efficacy of its celiac vaccine, Nexvax2, on celiac patients who carry the immune recognition genes for HLA-DQ2.5. Carriers of HLA-DQ2.5 account for approximately 90% of people with disease, and Nexvax2 is designed to protect these patients from the effects of gluten exposure.
Nexvax2 is currently the only disease-modifying ...

Read Full Article...

22 comments

16,686 views
Numerous Clinical and Histologic Conditions Mimic Celiac Disease
Celiac.com 04/12/2021 - Celiac disease is an autoimmune disorder of the small bowel, classically associated with diarrhea, abdominal pain, and nutritional deficiencies. Rapid diagnosis of celiac disease is important, since strict adherence to a gluten-free diet can resolve most resolution of clinical and histologic manifestations of the disease. Celiac disease is commonly misdiagnosed, most often as one of these conditions.
Numerous diseases and conditions can present with clinical and/or histologic features of celiac disease. In a recent review article, a pair of researchers highlight key clinical and histologic mimickers of celiac disease.
Many conditions that mimic celiac disease offer clues to the underlying diagnosis, and many have a targeted therapy. It is important...

Read Full Article...

7 comments

10,542 views
FDA Issues New Guidelines for Celiac Drug Trials
Celiac.com 07/04/2022 - The Food and Drug Administration (FDA) has issued a set of new guidelines for companies doing celiac disease drug trials. The agency noted that the guidance is intended only to provide clarity regarding existing requirements, and should be viewed solely as recommendations, unless they mention specific regulations or laws.
The FDA directs sponsors of trials for clinical drugs to ensure the following regarding celiac disease patients on a gluten-free diet:
Trial population
Patients should undergo diagnostic esophagogastroduodenoscopy, with multiple biopsies to confirm celiac diagnosis. The biopsies should include one or two samples of the duodenal bulb and at least four samples of the distal duodenum.
To avoid inclusion of patients whose ...

Read Full Article...

0 comments

3,543 views
Recent Activity
1. 56 minutes ago - knitty kitty replied to fatjacksonthecat's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
  19
  
  Nicotine Gum For Gluten Symptoms.. Am I Crazy?
  
  @sleuth, Has your son been checked for nutritional deficiencies? All of those symptoms can be caused by malnutrition. I had severe malnutrition that went unrecognized by my doctors. Intense fatigue, brain fog, depression, anxiety, and gastrointestinal distress are symptoms of deficiencies in the eight essential B vitamins, especially Thiamine B1,...
2. 1 hour ago - Scott Adams replied to Clear2me's topic in Gluten-Free Foods, Products, Shopping & Medications
  3
  
  Gluten free nuts
  
  They are a sponsor here, and I did noticed a free shipping coupon: GFships
3. 1 hour ago - Scott Adams replied to tiffanygosci's topic in Gluten-Free Foods, Products, Shopping & Medications
  1
  
  Aldi Pueblo Lindo Yellow Corn Tortillas
  
  In general if it is labelled gluten-free then it should be ok for most celiacs, however, those who are super sensitive (which is most who have dermatitis herpetiformis) may want to eat only certified gluten-free items, which are supposed to test down to 10ppm (but don't always!).
4. 8 hours ago - Wheatwacked replied to Jillian83's topic in Coping with Celiac Disease
  7
  Celiac and dermatitis herpetiformis has taken Me from Me
  
  Have faith, you will survive. I get mine from Pipingrock.com. 500 capsules of 10,000 IU for $22. That is almost two years worth for me. 250 caps 5000 IU for $6.69 if you only take 5,000 a day. It's like half the price of Walmart.
  
  1
  
  abuse
  
  alone
  
  (and 8 more)
  
  Tagged with:
  
  abuse
  
  alone
  
  broken
  
  exhausted
  
  lost time
  
  relationships
  
  sick
  
  starving
  
  struggling
  
  suffering alone
5. 18 hours ago - Wheatwacked replied to Riley.'s topic in Related Issues & Disorders
  5
  
  Outgrow celiac?
  
  Testing can't alone be trusted. Else why would it take so many years of testing and retesting and misdiagnosis to finally be told, yes you have Celiac Disease. As to what to eat, I like pre 1950 style food. Before the advent of TV dinners. Fresh food is better for you, and cooking from scratch is cheaper. Watch Rachel Ray's 30 Minute Meals for how...