Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate
  • Record is Archived

    This article is now archived and is closed to further replies.

    Scott Adams
    Scott Adams

    Down Syndrome: Stichting Down Syndrome

    Reviewed and edited by a celiac disease expert.

    Celiac.com Sponsor (A12):
    Erik de Graaf
    director, Stiching Down Syndrome (SDS)
    (i.e., the Dutch Down Syndrome Foundation)
    Vice-President of the European Downs Syndrome Association (EDSA)
    Bovenboerseweg 41
    NL-7941 AL Wanneperveen
    The Netherlands
    Tel.: -31-(0)522-28 13 37
    Fax.: -31-(0)522-28 17 99
    E-mail: Open Original Shared Link

    Leyden University Medical School just finished a large-scale investigation using 198 families who have a child with DS between the ages of 1 and 9 years old. 115 decided to have their child participate. The first researcher, Elvira George, made home visits and collected blood and urine for testing. A. o. values of anti-endomysium (EmA) were determined. Only if one of the investigated blood or urine values was significantly different from the norm was the child referred to the hospital to take a biopsy. That was the case with 43 of the 115 children. In 9 cases no biopsy was taken, in six because the parents refused it and in 3 because the childs condition didnt allow for it. Of the 34 children that had a biopsy taken, eight, or rather 7 % (!) of the original 115, had the intestinal appearance typical for celiac disease (according to international standards).

    Retrospectively, five of these eight children had complaints that were compatible with celiac disease, that were considered to be caused by DS as such until then. Three children were free of complaints. Their diagnosis was a complete surprise. In addition, it was proven that the value for EmA was the strongest indicator of a positive biopsy. If EmA was positive there always was celiac disease upon biopsy.

    Needless to say that all (so far but one) concerned children were put on a totally gluten free diet. It was reported that their complaints decreased rapidly. Celiac disease is considered to put people involved at risk for particular intestinal cancers, if they do not keep their diet. Therefore, the diet has to be maintained lifelong. This aspect makes testing for celiac disease so important in an at risk population as children with DS are. Even without complaints one in fourteen of our children might have it!

    It is postulated that the children that had different blood values but no positive biopsy can still develop celiac disease in the future. Their condition will remain be followed. Presently, the complete study is in the process of being published in international literature. There is the following pre-publication reference:

    • George, E. et al. The high frequency of celiac disease in DS: screening methods. Gastroenterology 1995; 108 (Supp 4): A 16

    For more information:

    • Medical & Surgical Care for Children with Down Syndrome Ed. by DC Van Dyke MD, Woodbine House l995 ISBN ## 0-933149-54-9 p. 185 ...one study found that individuals with DS are 20 times more likely than others to have a particular malabsorption syndrome known as celiac disease. This section is written by Timothy M Buie MD and references DS and Celiac Disease Pediatric Gastroenterology and Nutrition Vol. 10, No.1. l990 41-43 by Dias, J. and Walker-Smith, J.


    User Feedback

    Recommended Comments

    There are no comments to display.



    Guest
    This is now closed for further comments

  • Get Celiac.com Updates:
    Support Celiac.com:
    Donate
  • About Me

    Scott Adams

    Scott Adams was diagnosed with celiac disease in 1994, and, due to the nearly total lack of information available at that time, was forced to become an expert on the disease in order to recover. In 1995 he launched the site that later became Celiac.com to help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives.  He is co-author of the book Cereal Killers, and founder and publisher of the (formerly paper) newsletter Journal of Gluten Sensitivity. In 1998 he founded The Gluten-Free Mall which he sold in 2014. Celiac.com does not sell any products, and is 100% advertiser supported.


  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-M):




  • Related Articles

    Scott Adams
    Am J Med Gen 2001;98:70-74.
    Celiac.com 02/15/2001 - Dr. Susan L. Neuhausen and associates at the University of Utah School of Medicine in Salt Lake City studied 97 Caucasian children with Down Syndrome, ages 2 to 18 years. Their results, which were published in the January issue of the American Journal of Medical Genetics, show that 10 of the children tested positive for celiac disease (IgA anti-endomysial antibody). This is a rate that is about 25 times the general population.
    According to the results of genetic testing on these children, their genetic predisposition is the same as in the general population, which leads the researchers to believe that a gene on chromosome 21 may be involved in the pathogenesis of celiac disease.. The only symptom exhibited by the...


  • Recent Activity

    1. - trents replied to Art Maltman's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      2

      My 5 months of Struggle

    2. - Scott Adams replied to Dana Gilcrease's topic in Gluten-Free Foods, Products, Shopping & Medications
      4

      Gluten-Free Foods

    3. - Art Maltman posted a topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      2

      My 5 months of Struggle


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      126,491
    • Most Online (within 30 mins)
      7,748

    Constance E.
    Newest Member
    Constance E.
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      120.9k
    • Total Posts
      69.4k

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Popular Now

    • JA917
      11
    • Dana Gilcrease
      4
    • marion wheaton
      6
    • Jula
    • GardeningForHealth
  • Popular Articles

    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
  • Upcoming Events

×
×
  • Create New...