Celiac.com 04/12/2021 - Celiac disease is an autoimmune disorder of the small bowel, classically associated with diarrhea, abdominal pain, and nutritional deficiencies. Rapid diagnosis of celiac disease is important, since strict adherence to a gluten-free diet can resolve most resolution of clinical and histologic manifestations of the disease. Celiac disease is commonly misdiagnosed, most often as one of these conditions.
Numerous diseases and conditions can present with clinical and/or histologic features of celiac disease. In a recent review article, a pair of researchers highlight key clinical and histologic mimickers of celiac disease.
Many conditions that mimic celiac disease offer clues to the underlying diagnosis, and many have a targeted therapy. It is important...

Celiac.com 07/04/2022 - The Food and Drug Administration (FDA) has issued a set of new guidelines for companies doing celiac disease drug trials. The agency noted that the guidance is intended only to provide clarity regarding existing requirements, and should be viewed solely as recommendations, unless they mention specific regulations or laws.
The FDA directs sponsors of trials for clinical drugs to ensure the following regarding celiac disease patients on a gluten-free diet:
Trial population
Patients should undergo diagnostic esophagogastroduodenoscopy, with multiple biopsies to confirm celiac diagnosis. The biopsies should include one or two samples of the duodenal bulb and at least four samples of the distal duodenum.
To avoid inclusion of patients whose ...

Celiac.com 10/04/2023 - Neuropathic pain is a challenging condition with complex diagnostic and treatment issues. Although we've made progress in understanding and treating neuropathy, many aspects of this condition remain unclear. One intriguing aspect of neuropathy is that it can cause both sensory loss and pain, despite being driven by abnormal nerve signaling.
Voltage-gated sodium channels, crucial for proper nerve function and communication, can go awry in neuropathy, triggering hyperexcitability and pain. Even with a number of diagnostic tools available, neuropathy patients often face delays in getting an accurate diagnosis for the underlying cause.
The research team included Giustino Varrassi, Stefano Tamburin, Panagiotis Zis, Vittorio A. Guardamagna, Antonella Paladini...

Celiac.com 02/28/2024 - We get a lot of questions about what celiac disease trials and studies are going on, but there are so many, it can be hard to keep track. One easy source is the Mayo Clinic, which is at the forefront of a number of research trials, and studies to better understand, and treat celiac disease. Currently, there are more than a dozen exciting clinical trials underway, each focusing on different aspects of the celiac disease. 
One study aims to assess the effect of gluten on gut barrier function by using a novel gut permeability test developed by Mayo Clinic researchers. Another trial is evaluating the safety and tolerability of a potential new treatment, KAN-101, for celiac disease patients. 
Additionally, researchers are investigating the effectiveness a...