Celiac.com 03/25/2019 - Some researchers have suspected that myelin proteins may be involved in multiple sclerosis (MS). A recent report in Science and Translational Medicine, suggests that additional non-myelin-related protein may also play a role. Researchers examined protein samples from the brains of 31 people who had died from suspected or confirmed MS. They found that T cells from 12 people reacted to the enzyme guanosine diphosphate-L-fucose synthase, or GDP-L-fucose-synthase. The enzyme usually helps to process sugars that are crucial to cell function and communication, including the function and communication of neurons.
Researcher Dr Roland Martin, from the University Hospital of Zurich, Switzerland, has helped to figure out which myelin proteins and peptides come under...

Celiac.com 01/08/2020 - Researchers currently don't have much good information on the frequency of hypogammaglobulinemia (Ig deficiency) in people with multiple sclerosis. A team of researchers recently set out to assess the frequency of reduced immunoglobulin (Ig) concentrations and its association with immunotherapy and disease course in two independent multiple sclerosis study groups.
The research team included Greta Zoehner, Andrei Miclea, Anke Salmen, Nicole Kamber, Lara Diem, Christoph Friedli, Maud Bagnoud, Farhad Ahmadi, Myriam Briner, Nazanin Sédille-Mostafaie, Constantinos Kilidireas, Leonidas Stefanis, Andrew Chan, Robert Hoepner, and Maria Eleftheria Evangelopoulos.
The team's retrospective cross-sectional study included multiple sclerosis patients and control ...

Celiac.com 02/03/2023 - Multiple sclerosis is a chronic autoimmune disease of the central nervous system that affects individuals worldwide. People with multiple sclerosis often have other autoimmune diseases such as hypothyroidism, inflammatory bowel disease, rheumatoid arthritis, and diabetes, which suggests that there may be common genetic or environmental exposures between multiple sclerosis and other autoimmune diseases. 
Epidemiological studies have also shown that individuals with one autoimmune disease have an increased susceptibility to developing another autoimmune disease.
Celiac disease is an autoimmune gluten-sensitive enteropathy that results in small intestinal lesions and malabsorption in affected individuals. Celiac disease develops based on genetic factors ...

Celiac.com 09/25/2023 - Professor Jeffrey Hubbell and a team of researchers at the University of Chicago's Pritzker School of Molecular Engineering has developed a novel type of vaccine known as an "inverse vaccine." 
This innovative vaccine has shown promise in laboratory settings for the treatment of autoimmune diseases such as multiple sclerosis, type 1 diabetes, and Crohn's disease. Importantly, it achieves this without suppressing the entire immune system, as is often the case with current treatments. Could such treatment work for celiac disease? 
How the Inverse Vaccine Works
Traditional vaccines are designed to train the immune system to recognize and attack harmful viruses or bacteria. In contrast, the inverse vaccine takes a different approach. It aims to e...