Vijay Kumar, M.D., Research Associate Professor at the University of Buffalo and President and Director of IMMCO Diagnostics: If the tests are performed using well standardized tests with known positive and negative predictive values then you can make the statement that if the serological tests are negative celiac disease can virtually be ruled out. The problem is that some of these assays, especially the gliadin, can give you false positive results. In our laboratory we rarely see positive AGA results in the absence of EMA and ARA antibodies.
-
Welcome to Celiac.com!
You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.
-
Get Celiac.com Updates:Support Our Content
-
Record is Archived
This article is now archived and is closed to further replies.
By Scott Adams
By Scott Adams •
One case I know of had elevated gliadins (both types) but normal EMA and ARA, plus an inconclusive biopsy. Do you see this often?**
User Feedback
-
Get Celiac.com Updates:Support Celiac.com:
-
About Me
Scott Adams was diagnosed with celiac disease in 1994, and, due to the nearly total lack of information available at that time, was forced to become an expert on the disease in order to recover. In 1995 he launched the site that later became Celiac.com to help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives. He is co-author of the book Cereal Killers, and founder and publisher of the (formerly paper) newsletter Journal of Gluten Sensitivity. In 1998 he founded The Gluten-Free Mall which he sold in 2014. Celiac.com does not sell any products, and is 100% advertiser supported.
-
Related Articles
Vijay Kumar, M.D., Research Associate Professor at the University of Buffalo and President and Director of IMMCO Diagnostics: The three serological tests that are used for diagnosing celiac disease are:
Anti-endomysial antibody (EMA) Anti-reticulin antibody (ARA) Anti-gliadin antibody (AGA) Each of these three tests provide a certain degree of reliability for diagnosing celiac disease. Of these, endomysial antibody is the most specific test. The following table is taken from our studies (Lerner, Kumar, Iancu, Immunological diagnosis of childhood coeliac disease: comparison between antigliadin, antireticulin and antiendomysial antibodies).
% of Sensitivity % of Specificity Predictive Value % Pos Predictive Value % Neg EMA 97% 98% 97% 98% ARA 65%...
- Read Full Article...
- 1 comment
- 37,636 views
Vijay Kumar, M.D., Research Associate Professor at the University of Buffalo and President and Director of IMMCO Diagnostics: Absolutely yes. For the test to provide meaningful results, it must be validated using a large number of clinical documented subjects. In addition, the two tests, endomysial and reticulin are immunofluorescent tests where the readings are subjective. Experienced laboratory personnel are needed to read such tests.
Karoly Horvath, M.D., Ph.D., Associate Professor of Pediatrics; Director, Peds GI Nutrition Laboratory; University of Maryland at Baltimore: There are several advantages to use a laboratory experienced with the celiac serological tests:
Technically, the test are more reliable, and the internal and external control of tests are better...
- Read Full Article...
- 0 comments
- 7,917 views
For 100 units of whole grain wheat, about 70 units of white flour results from the milling process. The rest is separately sold as wheat bran or wheat germ. Those 70 units of flour are about 10%- 15% protein, thus about 7 to 10 units of protein for 100 units of whole wheat. The protein is about 80% gluten, thus about 6 to 8 units of gluten for 100 units of whole wheat. Since one typically sees wheat flour as an ingredient, applying the 70% factor implies 8 to 12 units of gluten per 100 units of wheat flour.
- Read Full Article...
- 0 comments
- 9,340 views
Celiac.com 02/05/2023 - If you have celiac disease symptoms, for example chronic diarrhea, anemia, bloating, abdominal pain, rashes, are in a higher risk group, etc., your doctor may order a blood test for celiac disease. Note that before doing any blood tests for celiac disease you must be eating gluten for a while beforehand, and the amount and length of time can vary, but is somewhere between 2 slices of wheat bread daily for 6-8 weeks and 1/2 slice of wheat bread or 1 wheat cracker for 12 weeks, otherwise you may end up with false negative results.
For a celiac disease antibody test, a clinician collects a small amount of the patient's blood. The sample is then sent to a lab, where the blood cells are then removed, and the test is conducted.
Celiac Disease Blood Tests <...>
- Read Full Article...
- 62 comments
- 237,561 views
Recent Activity
-
- knitty kitty replied to lizzie42's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease7
Help figuring out stomach pain
A multivitamin is great. Multivitamins contain lots of trace minerals we need. My only hesitation is that many use thiamine mononitrate which is not easily absorbed nor utilized by the human body. Thiamine mononitrate is used because it's cheap and shelf stable. You can add in a thiamine hydrochloride or a Benfotiamine supplement in addition to the multivitamin... -
- lizzie42 replied to lizzie42's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease7
Help figuring out stomach pain
Do you think a children's multivitamin might help? I just ordered the probiotic and also multi from hiya. I'm usually not into the multivitamin as my kids eat really healthy but maybe for the ones with celiac? -
- Scott Adams replied to Sanna King's topic in Gluten-Free Foods, Products, Shopping & Medications5
Any bad experience with King Arthur Gluten-free bread flour
BTW, you might find this article helpful: -
- Scott Adams replied to LMR123's topic in Super Sensitive People3
Is my dishwasher glutening me?
That is true! Many people with celiac disease, especially those who are in the 0-2 year range of their recovery, have additional food intolerance issues which could be temporary. To figure this out you may need to keep a food diary and do an elimination diet over a few months. Some common food intolerance issues are dairy/casein, eggs, corn, oats... -
- knitty kitty replied to lizzie42's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease7
Help figuring out stomach pain
We tend to crave foods that our bodies know contain the nutrients it needs. Her "meat kick" sounds like she's listening to her body's nutritional needs! Yes, do talk to her doctor and nutritionist about supplementing with a B Complex. Well done!
Recommended Comments
There are no comments to display.