Igg And Iga Tests

[giraffelover]

I talked our family doctor into testing my 14 year old daughter for gluten problems. He agreed and ran gliadin IgG antibody and her score was 16.4 u/ml and the range says normal is 0 to 9.9. Also a gliadin antibody IgA was done and her result was -1.2 u/ml and normal is 0 to 4.9. Can anyone tell me what these mean? She does have stomache aches and her first cousin is dx as celiac. My other child 12 year old daughter has been gluten free for one year now due to what we think is DH but we have not tested her since she willingly is gluten-free. I read the board but I have never posted. Any thoughts? Giraffelover

[Carriefaith]

Your daughters results indicate that she may have celiac disease or a gluten intolerance/sensitivity. Because she tested positive on the gliadin IgG antibody test, I would ask her doctor to test her with the Tissue Transglutamase Test (tTg). This test is highly specific for celiac disease. In addition, I would also ask to see if her doctor would test her for an IGA deficiency since her score was negative on the first one she had done. The tTg test is IGA and if she is deficient in IGA antibodies then her results would be false negative.

[giraffelover]

My daughter's grandmother had a anti gliadin IGA of 30 and endomysial IGA of 2. Would either of these scores indicate celiac and do my daughter's scores have any different meanings knowing about her grandmother? Giraffelover

[Carriefaith]

My daughter's grandmother had a anti gliadin IGA of 30 and endomysial IGA of 2. Would either of these scores indicate celiac and do my daughter's scores have any different meanings knowing about her grandmother?

The anti gliadin IGA seems high if the normal range is low. Celiac disease is genetic so if her grandmother had it then she could have passed it on. The best blood test for celiac in my opinion is the Tissue Transglutamase Test (tTg). However, it does not work well in individuals with an IGA deficiency. Getting multiple biopsies of the small intestine is also a great test for celiac disease.

[jenvan]

One thing I learned recently... IgAs typically tend to respond quickly to gluten...meaning, they will be the first to increase, and the first to decrease in response to a gluten-free diet. IgGs are slower responders and will be the last to increase in response to gluten and the last to decrease in response to a gluten-free diet. ie. I am 8/9 mos gluten-free and my IgAs are normal, but my IgG is still high. Maybe this info will help you... So the daughter who was tested is NOT gluten-free then?

[giraffelover]

The anti gliadin IGA seems high if the normal range is low. Celiac disease is genetic so if her grandmother had it then she could have passed it on. The best blood test for celiac in my opinion is the Tissue Transglutamase Test (tTg). However, it does not work well in individuals with an IGA deficiency. Getting multiple biopsies of the small intestine is also a great test for celiac disease.

<{POST_SNAPBACK}>

The daughter who was tested is not gluten free. Her sister has never been tested but is gluten free by choice because she itches so bad when eating gluten.