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Genetic Markers for Celiacs

Joshmitchell
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Joshmitchell Apprentice
Joshmitchell
Posted

So, my GI ordered a test for me to see if I had the genetic markers for celiacs. I have both of the markers he tested for. My endoscopy showed no damage. And all of my bloodwork was normal including the endomysial test. The only thing that was high was my Gliadin antibody test. I never really got that sick from eating gluten. Have I just been lucky? Will I start getting damage if I continue to eat gluten? Is there any chance at all that I don’t have celiacs? Thanks. 

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Scott Adams Grand Master
Scott Adams
Posted

Can you share your high blood test result along with the cut off level for celiac disease? 

If you have even one positive blood test for celiac disease, then you could still have it, or gluten sensitivity for which they currently can't screen, even though your gut isn't damaged (that could still happen later).

For your genetic test, are you saying that you're positive for both DQ2 and DQ8 genetic markers for celiac disease. If so, this puts you at mush higher risk than having just one of these markers.

Joshmitchell Apprentice
Joshmitchell
Posted
  • Author
3 hours ago, Scott Adams said:

Can you share your high blood test result along with the cut off level for celiac disease? 

If you have even one positive blood test for celiac disease, then you could still have it, or gluten sensitivity for which they currently can't screen, even though your gut isn't damaged (that could still happen later).

For your genetic test, are you saying that you're positive for both DQ2 and DQ8 genetic markers for celiac disease. If so, this puts you at mush higher risk than having just one of these markers.

IgA was 220. Standard range  is to 400
Gliadin IgA 29. Standard range is to 15

Gliadin Igg .6 standard is 15

transglutaminase IgA .5 standard is 15

Transglutaminase IGG is .8 

Endomysial was negative. 
 

And I had dq2 and dq8 markers. 

Scott Adams Grand Master
Scott Adams
Posted

So it looks like you're not IgA deficient (I believe it was 220 from what you posted), and your Anti-Gliadin IgA was positive. According to this article: "A sensitive testing protocol includes testing for both IgA and IgG anti-gliadin antibodies since a significant portion of celiac patients (approx. 2-5%) are IgA deficient. This combined IgA and IgG anti-gliadin antibody assay has an overall sensitivity of 95% with a specificity of 90%."

Generally speaking having one positive blood test for celiac disease should be enough for you to consider yourself in the gluten sensitive range (and possibly celiac disease), especially given your genetic makeup. If I were you I'd definitely consider going gluten-free, even if your doctor doesn't make this specific recommendation.

 

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