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Gluten Sensitivity Genes

booksrfun

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booksrfun Newbie
booksrfun
Posted

My daughter was tested through Enterolab and it showed that she did not have the 2 main genes necessary for celiac's disease but that she showed gluten sensitivity through some other genes (HLA-DQ 1, 3). Question: If you do not have either of the 2 main genes that almost ALL people w/ celiac's Disease have than is it still possible to get Celiac's ???? Kimball Labs which tests DNA says that if you do not have the two main genes for Celiac's than you do not/can not get it. (Info on their web site and you can call them) The Gastro doctor says that this is not the case and that you could still have it even if you do not have the genes. Is this, in fact, the difference between celiac's vs. gluten sensitivity??? Although both can do damage if you do not have the 2 main genes for Celiac's disease than you have the possible chance of healing your gut and later becoming less reactive to gluten and possibly reintroducing it into your diet like you do w/ other foods that cause allergies? I am confused about all of this conflicting info. Although my daughter does not have the 2 main genes for Celiac's she did show some malabsorption and scored both 10 for the fecal antigliadin IgA and Fecal antitissue transglutaminase IgA. The note from the lab said that she has dietary gluten sensitivity and an increased amont of fat in stool (score 339 w/ under 300 normal range). I e-mailed Enterolab these questions and did not receive a reply. Any info to enlighten me would be greatly appreciated.

Thanks, p.s. She is currently on a gluten free diet

Becky

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taneil Apprentice
taneil
Posted

When did you e-mail enterolab with your questions? They ususally reply within 24 hours unless Dr. Fine is on a trip then it may take longer, but if they received your e-mail he will respond.

I don't know about your gene questions though.

gf4life Enthusiast
gf4life
Posted

Did you e-mail Dr. Fine or Enterolab. If you e-mailed the lab dierectly they almost never respond, but if you e-mail Dr. Fine directly at kdxfine@yahoo.com , he will get back to you right away.

Two of my boys do not have the celiac genes (like my daughter and I do), but their doctor is not willing to rule out Celiac Disease. I was told their is just not enough known about the disease to know if they have isolated all of the genes that cause it, or if it is possible to get it without the genetic background. I believe this to be true, as there have not been as many studies on Celiac Disease and gluten sensitivity done as most other diseases get. And most doctors have no clue how to diagnose gluten sensitivity at all. If it isn't full blown celiac disease, then you are out of luck for a diagnosis. Thank God for Enterolab and Dr. Fine! :D

God bless,

Mariann

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      High DGP-A with normal IGA

      By knitty kitty · Posted

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    • captaincrab55
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    • rei.b
      High DGP-A with normal IGA

      By rei.b · Posted

      Okay well the info about TTG-A actually makes a lot of sense and I wish the PA had explained that to me. But yes, I would assume I would have intestinal damage from eating a lot of gluten for 32 years while having all these symptoms. As far as avoiding gluten foods - I was definitely not doing that. Bread, pasta, quesadillas (with flour tortillas) and crackers are my 4 favorite foods and I ate at least one of those things multiple times a day e.g. breakfast with eggs and toast, a cheese quesadilla for lunch, and pasta for dinner, and crackers and cheese as a before bed snack. I'm not even kidding.  I'm not really big on sugar, so I don't really do sweets. I don't have any of those conditions.  I am not sure if I have the genes or not. When the geneticist did my genetic testing for EDS this year, I didn't think to ask for him to request the celiac genes so they didn't test for them, unfortunately.  I guess another expectation I had is  that if gluten was the issue, the gluten-free diet would make me feel better, and I'm 3 months in and that hasn't been the case. I am being very careful and reading every label because I didn't want to screw this up and have to do gluten-free for longer than necessary if I end up not having celiac. I'm literally checking everything, even tea and anything else prepacked like caramel dip. Honestly its making me anxious 😅
    • knitty kitty
      High DGP-A with normal IGA

      By knitty kitty · Posted

      So you're saying that you think you should have severe intestinal damage since you've had the symptoms so long?   DGP IgG antibodies are produced in response to a partial gluten molecule.  This is different than what tissue transglutaminase antibodies are  produced in response to.   TTg IgA antibodies are produced in the intestines in response to gluten.  The tTg IgA antibodies attack our own cells because a structural component in our cell membranes resembles a part of gluten.  There's a correlation between the level of intestinal damage with the level of tTg antibodies produced.  You are not producing a high number of tTg IgA antibodies, so your level of tissue damage in your intestines is not very bad.  Be thankful.   There may be reasons why you are not producing a high quantity of tTg IgA antibodies.  Consuming ten grams or more of gluten a day for two weeks to two months before blood tests are done is required to get sufficient antibody production and damage to the intestines.  Some undiagnosed people tend to subconsciously avoid lots of gluten.  Cookies and cakes do not contain as much gluten as artisan breads and thick chewy pizza crust.  Anemia, diabetes and thiamine deficiency can affect IgA antibody production as well.   Do you carry genes for Celiac?  They frequently go along with EDS.
    • rei.b
      High DGP-A with normal IGA

      By rei.b · Posted

      I was tested for celiac at the same time, so I wasn't taking naltrexone yet. I say that, because I don't. The endoscopy showed some mild inflammation but was inconclusive as to celiac disease. They took several biopsies and that's all that was shown. I was not given a Marsh score.
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