Hla Typing Results

[healthygirl]

Hello,

I see a recent thread on HLA typing, but thought I would post this separately so it doesn't get lost in the previous thread...hope no one minds.

I had my testing done through my GI's office, so didn't go through Enterolabs for results...However, I am hoping some of you experts out there can help me understand the results a little better.

What I got was a report that shows Molecular and Serology results...they are as follows:

Molecular

DRB1* 01 DQB1*05 (I think this is Allelle 1??)

DRB1*13 DQB1*06 (I think this is Allelle 2??)

DRB3* B3

Serology

DR1 DQ5

DR13 DQ6

DR52

I think the DRB3 and DR52 are totally unrelated to the celiac genotyping...not sure why they are there, but am assuming I it is the DQB1*05,06 that I should be looking at. From what I have read they are both related to gluten intolerance....is that correct? Also, I have read that 05,06 are actually subtypes of 01, so does this mean I am a double 01 or is that unrelated? I have had positive dietary response to going gluten free, so plan on staying gluten free no matter what, but am just curious if anyone can shed more light on the results or point me in the right direction.

Thanks!!!

[fedora]

Hi,

These are both subtypes of DQ1, however they can be called DQ5 and DQ6.

The vast majority of genetically tested celiacs(realizing not all of them have been genetically tested) shows they have DQ2.5 or DQ8.

However, a very few do not have these genes. Of these some have DQ5 and some have DQ6( I remember seeing this in cases in Mexico). DQ5 has been linked with neurological symptoms of gluten intolerance.

On here I have chatted with people with biopsy confirmed celiac who have DQ 5, DQ 6, and DQ 7.

We all now gluten sensitivity is reason enough to be gluten free even if we are not celiacs and may never be.

[healthygirl]

Thanks Fedora,

I know that I get unpleasant side affects from eating gluten and the side affects became more apparent and seemingly worse each time I give myself a gluten challenge (I did two, one after being off about 4 1/2 months and one after being off again for about 2 months). I don't plan on going back onto gluten so am happy to be gluten free for the rest of my life regardless of what the tests actually mean. But it is kind of nice to know what the genetic results do mean to me....thanks again for your help!

[fedora]

I know it has been awhile, but I remembered answering this. Interestingly, I got my dd results back. She is DQ5 and DQ6.

I was wondering, healthy girl, sorry if I am being nosy, but do you have any other health problems not fixed by being gluten intolerant and any other problems associated with gluten intolerance.

I am wondering because my dd is only 7. I am wondering if her possible (long story)gluten intolerance was caused by something else(it could have been) or if there is anything to look for in association with it.

Her symptoms are mouth sores , cranky and moody behavior, and delayed growth for a year.

Thanksy.