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Question About Ttg

leadmeastray88

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leadmeastray88 Contributor
leadmeastray88
Posted

I went to the doctors to get a copy of my celiac 'panel', if thats what you want to call it.

The only thing they tested was my ttG (t Transglutaminase antibody) and it was negative.

How accurate is it? Does this mean for sure that I don't have Celiac's?

Thank you!

-Kim

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leadmeastray88 Contributor
leadmeastray88
Posted
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Anyone?

leadmeastray88 Contributor
leadmeastray88
Posted
  • Author

Sorry to 'bump', but if anyone could help out I'd really appreciate it :)

cruelshoes Enthusiast
cruelshoes
Posted
I went to the doctors to get a copy of my celiac 'panel', if thats what you want to call it.

The only thing they tested was my ttG (t Transglutaminase antibody) and it was negative.

How accurate is it? Does this mean for sure that I don't have Celiac's?

Thank you!

-Kim

It is not unheard of to have a negative TtG and still have celiac. The problem is compounded by the fact that they did not run the complete celiac panel. Without the Total IgA score, it i impossible to know whether or not one is IgA deficient. If it were me, I would return to the doctor by phone ir in person, and request the full celiac panel.

Antigliadin IgA and IgG

Anti-tissue Transglutaminase Antibody (tTG) IgA and IgG

Anti-endomysial IgA and IgG

Total serum IgA

It is also possible to have a negative TtG when the damage is still in its early stages.

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Both the anti-tTG and the EMA titers correlate with the severity of villous atrophy [26-29]. As a result in the presence of partial villous atrophy either antibody may be negative. In addition the mode of presentation of the celiac disease, i.e. presence of silent or subclinical celiac disease may be associated with a negative EMA [30]. Clinically seronegative celiac disease is similar to sero-positive celiac disease [23, 28] In view of the possibility of the presence of celiac disease in the absence of a positive anti-tTG or endomysial antibody the presence of a positive IgA AGA should prompt a biopsy [13]. Several studies have demonstrated that reliance on either anti-tTG or endomysial antibody as a single test will underestimate the prevalence of celiac disease [23, 25, 31, 32].
leadmeastray88 Contributor
leadmeastray88
Posted
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Thank you so much for providing me with that information :) That helped so much.

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