Pls Help Me Understand My Prometheus Blood Test Results

[ecitizen]

Hi, I'm hoping you can help me. My GI is useless and won't call me back to explain my prometheus test results to me. I finally had to have them email me the results since he wouldn't respond. The test results say the following:

Summary Interpretation: Results do not exclude a diagnosis of celiac disease

Serological markers for celiac disease not detected.

Assay Name:

Anti-Gliadin IgG ELISA (AGA IgG) < 1.2 U/ml (Range <10.0 U/ml)

Anit-Gliadin IgA ELISA (AGA IgA) 2.2 U/ml (Range <5.0 U/ml)

Anti-Human Tissue Transglutaminase IgA ELISA (TTG IgA) <1.2 U/ml (Range <4.0 U/ml)

Anti-Endomysial IgA IFA (EMA IgA) Negative (Reference Negative)

Total Serum IgA by Nephelometry (TOTAL IgA) 254 mg/dl

Alleles Detected: DQ2 heterodimer and DQ8

DQ2/DQ8 - 14X (Increased Risk Over Gen Pop) Very High (Relative Risk)

Your help in interpreting this results would be greatly appreciated.

[ravenwoodglass]

You have the two recognized celiac genes. Although your blood tests were negative they could be a false negative, up to 20% of us will have negative blood tests. If you are planning on having a endo and biopsy stay on gluten. If your not then do give the diet a good try and see if it helps your issues.

[ecitizen]

You have the two recognized celiac genes. Although your blood tests were negative they could be a false negative, up to 20% of us will have negative blood tests. If you are planning on having a endo and biopsy stay on gluten. If your not then do give the diet a good try and see if it helps your issues.

Thanks. My first non-prometheus blood test showed an elevated anti-gliadin IGA level of 38 H so I guess it was positive. This test above was after being gluten free for about 4 months. I also had an endoscopy which the GI specialist said was negative for celiac. I don't know what to think anymore. All I know is that my neuropathy is going away after being gluten free so it must be that. Any other thoughts?

[tarnalberry]

After being gluten free for 4 months, you can't run a blood test to find celiac. You have to be eating gluten for a while (3 slices of bread a day for 3 months).

[ecitizen]

After being gluten free for 4 months, you can't run a blood test to find celiac. You have to be eating gluten for a while (3 slices of bread a day for 3 months).

So I guess that's why the prometheus was negative since I've been gluten free? I had been gluten free for about a month when I got the endoscopy so maybe that's why it also showed up negative. Anyway, at least I'm feeling better with the neuropathy so it must be the gluten.