Jump to content
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Can Celiac Be Diagnosed Via Colonoscopy Biopsy?


Amyswalter

Recommended Posts

Amyswalter Newbie

During my colonoscopy, my doctor took biopsy from my inflamed terminal Ileum (lowest part of small intestine). Can celiac disease be diagnosed from a biopsy of that area, or does the biopsy HAVE to come from the top of my small intestine via the stomach?


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



Greg Rappaport Rookie

During my colonoscopy, my doctor took biopsy from my inflamed terminal Ileum (lowest part of small intestine). Can celiac disease be diagnosed from a biopsy of that area, or does the biopsy HAVE to come from the top of my small intestine via the stomach?

I'm not a doctor, but I do believe the latter is correct. When I was diagnosed (about 12 years ago) I had bloodwork (celiac panel - endomysial IGA antibody) done which came back positive. Next my gastroenterologist scheduled me for an endoscopy, which revealed flattening in my stomach and duodenum. Biopsies are also taken which are used in the overall assessment as well.

Best of luck.

cahill Collaborator

During my colonoscopy, my doctor took biopsy from my inflamed terminal Ileum (lowest part of small intestine). Can celiac disease be diagnosed from a biopsy of that area, or does the biopsy HAVE to come from the top of my small intestine via the stomach?

During my colonoscopy my doctor took 2 biopsy to check for microscopic colitis.

Celiac disease can be diagnosed from biopsys of the small intestine via endoscopy and/or blood work.

The Horticulturalist Apprentice

During my colonoscopy, my doctor took biopsy from my inflamed terminal Ileum (lowest part of small intestine). Can celiac disease be diagnosed from a biopsy of that area, or does the biopsy HAVE to come from the top of my small intestine via the stomach?

Technically, yes, it can be diagnosed that way.

The gold standard test, however, is with an endoscopy and several biopsies. Have a read up about it on a website like the Mayo Clinic of the Uni of Chicago Celiac Disease Center. I've read that it's better to have someone with some experience in diagnosing celiac do the endoscopy, I also read that many GI Docs do not take sufficient numbers of biopsies to give an. accurate diagnosis

heathen Apprentice

Celiac disease is a disease primarily of the small intestine, although you can see some changes in the colon that are non-specific. In other words, if you're going for biopsy, you have to get an EGD, although based on your history, your GI may opt to do a colonoscopy as well just to check things out.

Archived

This topic is now archived and is closed to further replies.


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      132,204
    • Most Online (within 30 mins)
      7,748

    Sarahmegan
    Newest Member
    Sarahmegan
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Upcoming Events

  • Posts

    • trents
      NCGS does not cause damage to the small bowel villi so, if indeed you were not skimping on gluten when you had the antibody blood testing done, it is likely you have celiac disease.
    • Scott Adams
      I will assume you did the gluten challenge properly and were eating a lot of gluten daily for 6-8 weeks before your test, but if not, that could be the issue. You can still have celiac disease with negative blood test results, although it's not as common:  Clinical and genetic profile of patients with seronegative coeliac disease: the natural history and response to gluten-free diet: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606118/  Seronegative Celiac Disease - A Challenging Case: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441776/  Enteropathies with villous atrophy but negative coeliac serology in adults: current issues: https://pubmed.ncbi.nlm.nih.gov/34764141/  Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS.
    • Xravith
      I'm very confused... My blood test came out negative, I checked all antibodies. I suppose my Total IgA levels are normal (132 mg/dl), so the test should be reliable. Still, I'm not relieved as I can't tolerate even a single biscuit. I need to talk to my doctor about whether a duodenal biopsy is necessary. But it is really possible to have intestinal damage despite having a seronegative results? I have really strong symptoms, and I don't want to keep skipping university lectures or being bedridden at home.
    • Scott Adams
      They may want to also eliminate other possible causes for your symptoms/issues and are doing additional tests.  Here is info about blood tests for celiac disease--if positive an endoscopy where biopsies of your intestinal villi are taken to confirm is the typical follow up.    
    • Scott Adams
      In the Europe the new protocol for making a celiac disease diagnosis in children is if their tTg-IgA (tissue transglutaminase IgA) levels are 10 times or above the positive level for celiac disease--and you are above that level. According to the latest research, if the blood test results are at certain high levels that range between 5-10 times the reference range for a positive celiac disease diagnosis, it may not be necessary to confirm the results using an endoscopy/biopsy: Blood Test Alone Can Diagnose Celiac Disease in Most Children and Adults TGA-IgA at or Above Five Times Normal Limit in Kids Indicates Celiac Disease in Nearly All Cases No More Biopsies to Diagnose Celiac Disease in Children! May I ask why you've had so many past tTg-IgA tests done, and many of them seem to have been done 3 times during short time intervals?    
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.