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Aah. I see. I have both genes, too. My 2 boys have the HLA DQ8 gene and my 2 girls have the HLA DQ2 gene.    So your question regarding how quickly one reacts.......depends on the amount of healing that’s already taken place, the amount of gluten ingested, stress, etc. I tend to get itchy hands a few hours after ingestion, a dull headache around the same time that eventually turns into a migraine overnight. The stomach pains start overnight as well. Other GI symptoms develop within 12 hours.    In my conversations With other celiacs over the past 25 years (since I was diagnosed), a celiac with one gene reacts the same as a celiac with both genes. In fact, my son was diagnosed at 14 months and reacted far worse than I did at that time. He’s asymptotic now and tests the boundaries of being a normal 21 year old. 

I'm finding the same - at the beginning I was taking it as and when I needed it which was not what the doctor instructed.  She told me to take it four times a day, two puffs each time, and now I'm finding it is really helping.   I have bought a wedge which I sleep on but I find I end up slipping off it at night, and sleeping in that position triggers off a bit of nerve pain I get in my right cheek, so halfway through the night I throw the wedge on the floor and sleep on a flatter pillow on my left side.  I think sleeping the first part of the night on that wedge has helped, esp. the nights I don't eat anything three hours before I go to bed.  There was no evidence of reflux in my endoscopy, but I do think I had it at the start of all of this and it probably set it all off (plus a bad cold virus perhaps). Yes... and stress doesn't help!  

You get one gene from each parent.  You could get a celiac gene from your mother, but a non-celiac gene from your father.  However, if you get a celiac gene from each parent, you are a double celiac.    In my family, my mother and my nephew are both double celiac, and both get extremely sick immediately from any gluten exposure including an imperceptible amount of cross contamination.   Being a double celiac like my mother was means that all of her children have a 100% certainty of receiving a celiac gene from her.

Since there are a lot of people with Type 1 diabetes who also have celiac disease, I’d recommend you talk to your doctor about getting screened for diabetes. More info:  https://www.celiac.com/articles.html/celiac-disease-amp-related-diseases-and-disorders/diabetes-and-celiac-disease/