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Seroconversion of Reticulin Autoantibodies Predicts Celiac Disease in Insulin Dependent Diabetes Mellitus

Mdki M, Hupponen T; Holm K, Hallstrom O, _Gut_ 1995; Feb 3692) pgs. 239-42

In a study of 238 children and adolescents with insulin dependent diabetes mellitus (IDDM), serum IgA reticulin

by an antigen which acts specifically against the antigen in an immune response. They typically consist of four sub-units that include two heavy and two light chains. Also known as immunoglobulin.'); return false">antibody tests were performed once a year. During the initial testing, within one year of the onset of IDDM, 5 children (2%) were positive. During follow up, 11 of the antibody-negative children (5%) became positive; of these 9 were shown to have silent celiac disease by jejunal biopsies. This study suggests that repeated serological screening and biopsies should be considered to detect late developing, clinically silent celiac disease among patients with IDDM.

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