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Celiac Disease May Cause Idiopathic Portal Hypertension

Celiac.com 04/07/2009 - Idiopathic portal hypertension is a malady of unknown cause, typically manifesting portal hypertension, splenomegaly and anemia secondary to hypersplenism.

Recently, a team of Iranian researchers encountered the case of a a 54-year-old male admitted for evaluation of malaise, weight loss, abdominal swelling and edema of the lower limbs.

The reporting team was made up of doctors Farhad Zamani, Afsaneh Amiri, Ramin Shakeri, Ali Zare, and Mehdi Mohamadnejad, of the Department of Pathology, and the Gastrointestinal and Liver Disease Research Center of Firouzgar Hospital at the University of Medical Sciences in Tehran, and the Digestive Disease Research Center of Shariati Hospital at Tehran University of Medical Sciences.

The patient's clinical evaluation showed pancytopenia, large ascites, splenomegaly and esophageal anomalies associated with portal hypertension.

Blood tests and small intestinal biopsy showed the presence of celiac disease. Patient's symptoms improved with a gluten-free diet, but improvement was further impaired by ulcerative jejunoileitis, and intestinal T-cell lymphoma.

From these results, the researchers conclude that celiac disease, by means of a heightened immune response in the splenoportal axis, can lead to the development of idiopathic portal hypertension in susceptible affected patients.

J Med Case Reports. 2009; 3: 68.

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13 Responses:

 
David Lapham Sr
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said this on
08 Apr 2009 4:20:09 AM PST
Good information. Would like to know more of the symptoms though.

 
A.J.
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said this on
08 Apr 2009 8:16:38 AM PST
There is the use of too many medical terms that the average reader doesn't know the meaning of, therefore reading this article by anyone other than a medical student or doctor is like reading in a foreign language that you don't know. It's a waste of time to the average person who is dealing with celiac.

 
Connie
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said this on
08 Apr 2009 5:02:38 PM PST
What does all of this mean? I am struggling with extended symptoms and I just don't understand what this is all about? Perhaps this means me?

 
L.N.
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said this on
08 Apr 2009 8:31:57 PM PST
I agree with A.J. - all this article does is freak me out! What do all those medical terms mean?? The only bits I understand are Coeliac and anaemia (both of which I have).... should I be worried about this mysterious idiopathic portal hypertension?!

 
Nicholas
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said this on
20 Oct 2011 9:43:24 PM PST
Idiopathic portal hypertension is an unexplained blockage in the portal vein causing reduced blood flow. Normally portal hypertension is caused by cirrhosis. 'Idiopathic' I believe means unknown cause.

I have portal hypertension so I have some idea.

Cirrhosis however is normally the cause of excessive drinking, you see a lot of drinkers with portal hypertension and cirrhosis.

I do not drink and am 25 years of age, my cirrhosis came from an auto-immune deficiency (celiac). For the longest time my condition was called 'idiopathic portal hypertension'

I would worry about it if you start experiencing an enlarged spleen (normally part of portal hypertension) this can be felt through pain in the left side under your ribs, tinging in your left shoulder or arm, or a bloated stomach. It looks different from weight gain because your stomach swells like a balloon. Or if you are bleeding excessively or bruising easily.

Liverwise, If you are extremely worried you can always have a liver biopsy or an ultrasound. Normally they won't to a biopsy without the presence of scarring on the ultrasound.

I hope that explains it. I wish you good health

 
Brenda
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said this on
08 Apr 2009 9:29:35 PM PST
What causes what?? Ok celiac I get... beyond that...

 
Raymond Craig
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said this on
09 Apr 2009 1:49:53 AM PST
I agree with David. It would be helpful to know more about this one case before drawing a strong conclusion based on a somewhat vague phrase like 'susceptible adults.' What might make them susceptible? Just celiac disease? If so, where are all the other cases?

 
Dick Wilkins
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said this on
09 Apr 2009 11:46:40 PM PST
I agree with #2. I still don't know what he was talking about. I don't know how to compare with my condition to see if I should investigate further.

 
Jannice Gentry
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said this on
15 Apr 2009 4:38:43 PM PST
I could not understand the meaning of this article, there are so many medical terms I do not understand.

 
Brandi Grev
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said this on
05 Dec 2009 11:44:12 PM PST
Those of us looking for answers are sadly left feeling frustrated by this article.

 
Willa Reddig
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said this on
15 Apr 2010 11:42:44 AM PST
I agree with all the previous entries, and now I'm worried I might have something, because I just can't get to feeling up to par.

 
Robena
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said this on
10 Oct 2011 11:54:39 AM PST
Totally agree with all of the above. How can I interpret whether it pertains to me or not, when I can't understand 90% of what I am reading.

 
Nicholas
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said this on
20 Oct 2011 9:34:15 PM PST
I have celiac and have and enlarged spleen, portal hypertension and cirrhosis of the liver. I am not a drinker and have had it since I was 21. So I believe without question it causes portal hypertension if left undiagnosed.

Thank you for writing up something so rarely noted in medicine journals but which is so important.




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