Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Help Celiac.com:
    eNewsletter
    Donate
  • Record is Archived

    This article is now archived and is closed to further replies.

    Jefferson Adams
    Jefferson Adams

    Better Celiac Diagnosis Has No Impact On Death Rates

    Reviewed and edited by a celiac disease expert.
    Better Celiac Diagnosis Has No Impact On Death Rates - New AJG study on celiac diagnosis and death rates.
    Caption: New AJG study on celiac diagnosis and death rates.

    Celiac.com 03/02/2011 - New blood screening tests have improved rates of diagnosis for celiac disease in recent decades, but better diagnosis has not reduced celiac-associated deaths, according to a report by UK researchers in the American Journal of Gastroenterology.

    After serologic tests became available, there was an approximate tenfold increase in the numbers of people being diagnosed with celiac disease. Intuitively, one would expect this increase in diagnosis to be followed by a decrease in celiac-related deaths. The idea being that earlier diagnosis means earlier treatment with gluten-free diet, and, ideally, less associated conditions and deaths.

    Celiac.com Sponsor (A12):
    However, the newest study in this area shows evidence of any change in all-cause mortality among people with celiac disease. That means that even with better, earlier diagnosis, people with celiac disease are still dying at the same rates as before.

    Researcher Dr. Matthew J. Grainge, of the University of Nottingham, told Reuters Health that his team "found that people with celiac disease have a 37% increase in all-cause mortality compared with the general population."

    His team found that people diagnosed with celiac disease since 2000 have a similar mortality risk as those diagnosed earlier despite the introduction of serological tests, "which has probably resulted in milder cases being identified," Grainge said.

    For their study, the research team reviewed data on 1092 celiac disease patients diagnosed from the late 1950s onward, and who had been followed for a minimum of two years.

    The team examined outcomes from 1978 until death or through the end of 2006. All study subjects were diagnosed at a single center and the study covered both the pre- and post-serology era. The study covered more than 10,000 person years of follow-up,  and tallied a total of 142 deaths.

    The study revealed a significantly increased all-cause standardized mortality ratio (SMR) of 1.37. This was higher for men (SMR, 1.86) than for women (SMR, 1.10). Study subjects had higher rates of death from cancer (SMR, 1.61) digestive (SMR, 2.19) and respiratory diseases (SMR, 1.57) compared to the general population. In all, there were 21 deaths from respiratory diseases, 11 of those from pneumonia.

    According to the research team, this data supports current guidelines recommending pneumococcal vaccination for people with celiac disease.

    In conclusion, the researchers note that the results may offer doctors "an opportunity to reduce mortality following pneumococcal infection by increasing the uptake of vaccination against this pathogen as vaccination rates are currently well below 50%."

    Source:

    • Open Original Shared Link.


    User Feedback

    Recommended Comments

    Guest Amy Buchert

    Posted

    Great information for celiacs!! I suffer from upper respiratory infections almost yearly and will now receive the Pneumococcal vaccine next fall.

    Link to comment
    Share on other sites
    Guest Dr. Murdocco

    Posted

    Interesting and informative.

    Link to comment
    Share on other sites
    Guest Helen Haas

    Posted

    I find this article very helpful I have had celiac since 78 years old now 83 and doing just fine the gluten-free breads have gotten so much better since I first was diagnosis the pies & cakes haven't improved much.

    Link to comment
    Share on other sites


    Guest
    This is now closed for further comments

  • Get Celiac.com Updates:
    Help Celiac.com:
    Donate
  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     


  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-M):




  • Related Articles

    Scott Adams
    Arch Dis Child 2006;91:39-43.
    Celiac.com 12/08/2005 – Researchers in the United Kingdom conducted a systematic review and meta-analysis of 15 studies published between 1966 and 2004 that evaluated the association between breast-feeding and celiac disease. Their review covered more than 4,000 children and found that breast-feeding may offer protection against the development of celiac disease, especially if it is prolonged and covers the period when gluten is introduced. It was unclear, however, whether breast-feeding merely delays the onset of symptoms, or actually offers permanent protection against the disease, and more long-term prospective cohort studies will be necessary to make such a determination.


    Jefferson Adams
    Celiac.com 06/30/2008 - The results of a Hungarian study published recently in the June issue of Pediatrics suggest that people with untreated celiac disease show abnormal resistance to the hepatitis B (HBV) vaccine, while celiac patients on a gluten-free diet show a near normal response to the vaccine.
    A team of doctors led by Dr. Eva Nemes, at the University of Debrecen, administered 2 to 3 doses of recombinant HBV vaccine to 128 patients with celiac disease and an age matched control group of 113 non-celiac patients within a 6-month period. Twenty-two of the celiac patients were following a gluten-free diet when they received the vaccine.
    One month after the last HBV vaccination, the team took blood samples to look for anti-HBV antibodies. The group of 22 patients who received...


    Jefferson Adams
    Celiac.com 06/09/2009 - Results of a recent small population study done in Spain suggest that a gluten-free diet may change gut bacteria balance by decreasing beneficial bacteria and increasing detrimental bacteria. Certainly, gut health is an issue to most people with celiac disease. Recent studies suggest that people with celiac disease benefit from bifidium and lactobaccilus supplements, so it's possible that such benefit is in part an offsetting of damage due to gluten-free diet; at least, a connection seems possible.
    The Spanish study follows just ten individuals for just one month on gluten-free diets. A large-scale, long-term study might make very different observations, and reach very different conclusions.
    The study found no significant differences in dietary intake before...


    Jefferson Adams
    Celiac.com 02/27/2014 - For many people with celiac disease, one of the numerous downsides of the condition is the constant threat of an adverse reaction triggered by accidental gluten consumption. Because reactions to gluten ingestion can be severe for some celiac patients, many clinicians are looking to see if anything can be done to lessen the effects gluten reactions in celiac patients once they have started.
    A team of researchers sought to provide at least one possible answer by looking into the safety and efficacy of Aspergillus niger prolyl endoprotease (AN-PEP) to lessen effects gluten reactions in celiac patients. The researchers included G.J. Tack, J.M. van de Water, M.J. Bruins, E.M Kooy-Winkelaar, J. van Bergen, P. Bonnet, A.C. Vreugdenhil, I. Korponay-Szabo, L. Edens, B...


  • Recent Activity

    1. - CatherineWang replied to B1rdL0ver's topic in Related Issues & Disorders
      40

      Dealing with constant nausea and just feeling awful.

    2. - cristiana replied to BunnyBrown's topic in Related Issues & Disorders
      3

      Recently had my esophagus dilated

    3. - cristiana replied to twe0708's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      54

      How Long Do Celiac Patients Live?

    4. - Exchange Students replied to Exchange Students's topic in Parents, Friends and Loved Ones of Celiacs
      2

      Exchange Students who are celiac in need of host

    5. - Scott Adams replied to Exchange Students's topic in Parents, Friends and Loved Ones of Celiacs
      2

      Exchange Students who are celiac in need of host


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      120,164
    • Most Online (within 30 mins)
      7,748

    tracyg622
    Newest Member
    tracyg622
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      120.2k
    • Total Posts
      1m

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Popular Now

    • Sunflowers06
      6
    • Momkaren
      10
    • Elizabeth M Blair
      5
    • B1rdL0ver
    • twe0708
      54
  • Popular Articles

    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
  • Upcoming Events

×
×
  • Create New...