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Celiac Disease & Gluten Intolerance Research

This category contains summaries of research articles that deal strictly with scientific research publications on celiac disease. Most of these research summaries contain the original source of the publication.

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    Image: Sourdough starter: CC--andersbknudsen
    A team of researchers has found that gluten-free sourdough products may help speed recovery at start of gluten-free diet.


    Photo: CC - Jeremy Bronson
    Biopharmaceutical development company, BioLineRx, has announced results from pre-clinical trials which show that their compound, BL-7010, an orally available treatment for celiac disease, reduces the toxic effects of gluten in patients with celiac disease.


    Photo: CC - jimmedia
    After numerous studies over several decades showing higher mortality rates in people with celiac disease, including a comprehensive study in 2009, published in Gastroenterology, news of a recent UK study, finding mortality rates for people with untreated celiac disease that are similar to the general population, has raised a few eyebrows.


    Photo: CC - articotropical
    A clinical research team wanted to determine if adding ascorbate (vitamin C) to gliadin-stimulated biopsy culture could reduce the mucosal immune response to gliadin in people with celiac disease.


    Photo: CC - sanofi pasteur
    People with thyroiditis and untreated celiac disease may suffer from reduced thyroid-stimulating hormone levels, a new study has found. Those people may require supplemental doses of thyroxine to normalize their thyroid-stimulating hormone levels.


    Photo: CC - rdecom
    A group of researchers recently studied the ways in which HLA-DQ2 and DQ8 might influence the severity of celiac disease. Specifically, the team wanted to study HLA-DQA1 and DQB1 profiles in adults with different forms of celiac disease, including adults with complicated and potential celiac disease, the most seriously affected, and those with the best preserved histologic data on the pathologic celiac spectrum.


    Photo: CC--tiny.cc
    Even though nearly all drug-development programs include gluten challenges, very little is known about the duration of gluten challenge and gluten dosage. That is, how quickly does gluten cause damage, and at what dosages?


    Photo: Leeds Museums Galleries, UK.

    Currently, the best way to assess whether patients with celiac disease are actually maintaining a strict gluten-free diet is to have trained experts conduct a dietary interview. These interviews can vary in complexity, depending on the nature and number of the questions, and on the amount of medical expertise required to score the responses.



    Photo: CC-hagit
    Currently, testing for anti tissue-transglutaminase antibodies is the standard of celiac disease blood testing. The test has a high sensitivity in patients who are eating a diet that contains gluten, but poor sensitivity for people on a gluten-free diet. So, it's not much use for measuring gluten-free diet success in people with celiac disease.


    Photo: CC-Bogdan Suditu
    A research team recently conducted a dense genotyping non-HLA risk loci previously associated with immune-mediated diseases in individuals with celiac disease.


    Some studies suggest that people with celiac disease may have high levels of resistance to the HBV vaccine, compared to the general population. A team of researchers recently took a look at the issue of HBV vaccine reliability in people with celiac disease.


    Photo: Gene Davis -- Smithsonian Institution
    Should there be mass screening for celiac disease? Currently, there is no consensus among scientists or among public policy makers in favor of mass screening for celiac disease as a public health intervention. Advocacy for mass celiac disease screening remains somewhat controversial.


    Photo: CC--Glenn Fleishmann
    A research team recently set out to examine connections between childhood celiac disease and functional gastrointestinal disorder in children meeting Rome III criteria.


    Photo: CC-sanofi_pasteur
    A team of researchers recently set out to investigate structure-based selection of small molecules to alter allele-specific MHC Class II antigen presentation


    Photo: CC -- spec-ta-cles
    Celiac disease often results in "leaky" intestinal mucosa. This development may involve changes in hydrophobicity of the mucus surface barrier along with changes of the epithelial barrier.


    PPhoto: CC - RamberMediaImages
    A research team recently set out to determine whether loss of tolerance to gluten may develop at any age, to investigate possible long-term changes in celiac disease prevalence, and to better understand other celiac-related issues.

    A research team recently set out to determine how vitamin D and K might influence bone mineral density and bone growth in children and adolescents with celiac disease.

    A research team set out to examine the role of nuclear factor erythroid 2-related factor2 in gliadin-mediated toxicity in human Caco-2 intestinal cells and in gliadin-sensitive human leukocyte antigen-DQ8 transgenic mice (DQ8), along with assessing the protective activity of CLA.


    Image: CC-Kalakuta Citizen
    Very little study information exists concerning rates of celiac disease-predisposing, HLA-related genes in Arab populations. A research team recently investigated the distribution of HLA-DQ2 and -DQ8 genotypes in Libyan children with celiac disease, and in healthy control subjects.


    Photo: CC- kaibara87
    A discussion of the article "Identification of rothia bacteria as gluten-degrading natural colonizers of the upper gastro-intestinal tract," and its implications for the development of celiac disease.

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