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Celiac Disease & Gluten Intolerance Research

This category contains summaries of research articles that deal strictly with scientific research publications on celiac disease. Most of these research summaries contain the original source of the publication.

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    Diabetes Care celiac antibody research
    It has been well documented that Type 1 diabetics' risk for thyroid disease and celiac disease are very high. As such the American Diabetics Association advises young children and adolescents that are diagnosed with Type 1 diabetes, to also have their thyroid function monitored and undergo celiac screening.

    Journal of Clinical Laboratory Analysis celiac study
    In an effort to better understand any connection between psoriasis, celiac disease, and the HLA Cw6 genotype, a research team examined the expression of celiac-associated antibodies gliadin IgA, gliadin IgG, and tissue transglutaminase IgA, and possible associations the antibodies may have with the HLA Cw6 gene in people with psoriasis.

    QJM celiac study
    A group of researchers recently set out to establish the amount of time it takes for full gut recovery in patients with celiac disease.

    There is very little information currently available regarding the effects of follow up strategies for those celiac patients that follow a gluten-free diet. Therefore, it was the aim of of researchers in Italy to determine the t-transglutaminase antibodies (t-TG) in celiac disease patients while they were enrolled in a community based follow-up program over a 5-year period.

    New Science Translational Medicine research on celiac trigger
    In a breakthrough that may pave the way for the development of the first drug treatments for celiac disease, researchers claim to have identified the molecular triggers for the chronic, painful gut disorder.

    Very little research has been done regarding the psychological and social challenges faced by people with celiac disease who are attempting to follow a gluten-free diet. A team of clinicians assessed psychological and social challenges faced by Indian children with celiac disease who are attempting to follow a gluten-free diet.

    New Study on CD and Multiple Autoimmune Diseases
    An international research team set out to investigate any connection between this single nucleotide polymorphism (SNP) with autoimmune diseases in non-European populations.

    Photo:/ CC Rob Lee
    Celiac disease was at one time considered a rare disease. However, celiac is now gaining notoriety as a common genetic autoimmune disease that affects approximately 1% of Western countries. As the celiac epidemic starts to rise, the costs of medical diagnosis and treatments for celiac disease are now being scrutinized.

    The enteropathy associated with common variable immunodeficiency (CVID) is the most common  symptomatic primary antibody deficient syndrome, with an estimated prevalence of one in one-hundred thousand to one in fifty thousand. However, the relationship between CVID and Enteropathy is still unclear.

    Photo: CC/Evil Erin
    Acute abdominal pain is the most common symptom leading to emergency surgery; accounting for up to 50% of emergency surgical admissions and nonspecific abdominal pain (NSAP) likely accounts for 40% of the cases. While abdominal pain can often be a symptom of celiac disease, up until this point there have been no official studies to determine the  the association of celiac disease and abdominal pain.

    Studies on the genetic links to celiac disease are leading to more research which may lead to new and more effective ways to treat the disease, an exciting prospect for celiacs who may want to enjoy some gluten now and then.

    Recent scientific evidence suggests that gut microbiota may play a significant role in celiac disease. To further examine the role of gut microbiota in celiac disease, an Italian research team conducted a study of children with celiac disease.

    The Endocrine Society 92nd Annual Meeting
    A new limited study concludes all children under 5 years of age should probably receive at least 1000 IU of vitamin D daily as opposed to the current American Academy of Pediatrics recommendation of only 400 IU vitamin D daily.

    New research on hemolysis and celiac disease.
    Doctors describe how hemolysis interferes with the detection of anti–tissue transglutaminase antibodies in celiac disease.

    Potential treatment for T-cell lymphoma
    A team of researchers recently evaluated enteropathy-associated T-cell lymphoma and compared standard therapies with a novel regimen including autologous stem cell transplantation

    Irish Study of Gluten-Free Breads
    New research is currently underway in Ireland, as researchers test "pseudo-cereals" to determine the quality of  replacements for glutenous grains such as, wheat, rye and barley. Many celiacs, especially those with delayed diagnosis', suffer from malabsorbtion and malnutrition. It is therefore more important for celiacs to ingest grains that are vitamin fortified than it is for non-celiacs.

    A clinical research team recently examined the increased expression of hypoxia inducible factor 1alpha in celiac disease. They found increased mucosal HIF-1alpha expression in children with celiac disease that suggests influences from this signaling pathway in the pathological mechanisms of celiac disease.

    Diagnostic testing for celiac (photo courtesy of Brymo)
    Celiac disease is a genetic, permanent auto-immune disease with a variety of symptoms which, when treated with a gluten-free diet, usually subside. While clinical presentation is variable, most patients that are treated for abdominal pain do not have celiac disease. It is therefore important to accurately diagnose celiac disease in patients exhibiting abdominal pain, without unnecessarily testing  patients that do not have celiac disease.

    People born via cesarean are at greater risk for celiac disease.
    Celiac disease affects 1 in 100 people in the United States, and an estimated 97% of those people are undiagnosed. Meanwhile, scientists are working fervently to determine the underlying cause of celiac disease and also, a cure.

    The results of a recent study show that people with celiac disease have defects in their primary pathways for water and solute absorption that may play a role in the onset of malabsorption symptoms.

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