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Dgp Meaning Needed In Easy To Understand Terms

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can anyone explain what exactly it means when the gliadin peptide becomes deamidated?  what causes this?  all the scientific wording I keep finding is too confusing for me to really understand the concept, so simple terms would be much appreciated  :rolleyes:  thanks!


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It is pretty hard to do in layman's terms (not that I could do it myself anyway :P )  The following abstract is not too "abstract" or technical and might allow you to get the gist of it:


Celiac disease (celiac disease) is an (auto)immunologically mediated intestinal intolerance against proteins from wheat (gluten) and related cereal proteins. Tissue transglutaminase (tTG) has been identified as the autoantigen in celiac disease. Although ultimate diagnosis is based on histological analysis of small intestinal mucosa obtained via tissue biopsy, assessment of autoantibodies can provide substantial help in the evaluation of celiac disease. Gliadin antibodies are directed against the native disease-provoking cereal proteins. Despite their initial usefulness, these antibodies have lost diagnostic importance due to their poor specificity and sensitivity as celiac disease markers. Recently, it was found, however, that gliadin antibodies from sera of patients with active celiac disease preferentially recognized deamidated gliadin peptides. The use of deamidated gliadin peptides in immunoassays has significantly improved the usefulness of gliadin antibodies in diagnosis of celiac disease to that observed with autoantibody assay methods (endomysium antibodies, antibodies against tTG). The antibody epitopes (B-cell epitopes) reflect substrate specificity of tTG and resemble peptide sequences known to be strongly T-cell stimulatory (T-cell epitopes) in celiac disease. The assay applying deamidated gliadin peptides measures a new species of antibodies, which is different from conventional gliadin antibodies as well as from autoantibodies and will likely provide new information on pathophysiological mechanisms of celiac disease.


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    • are your new negative results with or without a gluten challenge? i think its irresponsible for your doctors to dismiss positive bloodwork. i agree that positive blood results points towards at least potential celiac disease and there is a good chance that there either wasn't enough damage yet or they missed it. pretty sure high Gliadin IgG means you were having an immune response to gluten. ttg IgG is less specific/sensitive than Iga but nonetheless it is an antibody related to tissue damage in the small bowel.
      seems common for GIs to deem celiac blood work as unreliable and then glaze over the fact that biopsy results can also be unreliable.
      if you have/are doing a gluten challenge i would ask for an EMA bloodtest and DGP not just ttg. if not maybe get the genetic test?    
    • I have the same symptoms.  These symptoms have overlapped other issues that I have and have been left untreated for far too long. Now the pain has gotten worst. My GP believes it's my hiatal hernia.  I have pain below my breastbone, pressure pushing up my chest/throat, dizziness and nausea. 
    • Usually I'm using apps to tell me what celiacs have thought about the restaurants in the area and repeatedly eating at a few different places I haven't gotten sick. Now that I think about it, gluten was a definite possibility. I ,however, just got all negative results from all the following tests so I'm guessing I'm doing ok on that front. -Basic metabolic panel -Liver enzyme panel -CBC -Serum IgA -Tissue transglutaminase(tTG), IgA -Tissue transglutaminase(tTG), IgG -Thyroxine(T4), free direct serum -Thyroid stimulating hormone I thought the same thing about positive antibodies and non-celiac sensitivity reading this; l'm seeing his nurse practioner in two weeks so I'm going to take this and basically argue with what he said and see how that goes haha. I'm gonna guess not real well. I'm going to push being tested for other autoimmune diseases in addition.  
    • I was dx with duoedenitis end of August. No mention of a stomach, esophagus or duoendal ulcer. Just a small hernia. Less then 2cm. But I have a LOT of pain right below the breast bone and I jumped when it was recently touched on exam. I can even feel a small bump in the area. I feel so dizzy and unwell, like some kind of bacteria is invading my brain and am very queasy still.  My heart still feels weird too.  Bloodwork normal, a bit low on protein which is unreal because I get a ton of it but it is always is low if I have not eaten. Mildly elevated myeloycytes and basophils. My GI will probably not see me for a week or two, my primary care put me on sucralfate.  As soon as the food hits my digestive system I feel really weird all over, stomach, chest, throat, head. Just feel like I have this horrible thing infecting my body.  Did anyone feel ulcer pain and have it NOT be an ulcer? I suppose one could have developed since August. 
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