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Elevated Ttg On Enterolab Test

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Posted 25 February 2012 - 06:02 PM

I am wondering about the significance of an elevated tTG fecal test from EnteroLab.

When my frequent, loose bowel movements turned into diarrhea almost two years ago, I immediately thought of celiac because my son had a celiac diagnosis as a baby (outgrew it?—another story). When a two month trial of a gluten-free diet alleviated my diarrhea, I asked my PCP for a celiac test. I didn’t know that I had to be eating gluten to get a positive diagnosis—unfortunately, my doctor didn’t know either, so my test came back negative.

After finding this forum and reading here about EnteroLab, I sent in a sample for testing. My results:

Anti-gliaden IgA 219 (normal less than 10)
Anti-tissue Transglutaminase IgA 86 (normal less that 10)

I do not have either of the celiac genes so I consider myself gluten sensitive—not celiac.

On the basis of the gliaden reading I went on a gluten-free diet. I pretty much ignored the tTG results because I had no idea what it might mean for me. Several months ago Skylark posted for someone on another thread, “TTG from Enterolab is more of a concern because it’s an autoimmune antibody. In your symptomatic daughter I would take Enterolab TTG very seriously.”

I’m gluten free (gluten-free household) and have uncovered a sugar (honey, agave, xylitol, raisin, date) sensitivity. However, there’s something else that I haven’t been able to uncover yet. I’m just wondering if the elevated tTG reading has any significance in all of this.

I came across this in my reading this afternoon from a recent publication:

“GS is a condition distinct from celiac disease and is not accompanied by the concurrence of anti-tTG autoantibodies or other autoimmune comorbidities.”

From: Spectrum of gluten-related disorders: consensus on new nomenclature and Classification BMC Medicine 2012
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