Celiac.com Sponsor (A1):


Join eNewsletter


Celiac.com Sponsor (A1-m):



Join eNewsletter
  • Join Our Community!

    Ask us a question in our celiac / gluten-free forum.

  • Scott Adams

    Does an Interplay Between Type 2 Transglutaminase (TG2), Gliadin Peptide 31-43 and Anti-TG2 Antibodies Promote Celiac Disease?

    Scott Adams
    0
    Reviewed and edited by a celiac disease expert.

      Can type 2 transglutaminase (TG2), gliadin peptide 31-43 and anti-TG2 antibodies work together to trigger celiac disease?


    Image: CC BY-SA 4.0--Roger Burger
    Caption: Image: CC BY-SA 4.0--Roger Burger

    Celiac.com 07/23/2020 - Celiac disease is a common inflammatory autoimmune condition that is influenced by both genetic factors and environmental triggers. Researchers still don't know very much about the early genesis of celiac disease. A team of researchers recently set out to describe the interplay between type 2 transglutaminase (TG2), gliadin peptide 31-43 and anti-TG2 antibodies in celiac disease.

    The team included Stefania Martucciello, Silvia Sposito, Carla Esposito, Gaetana Paolella, and Ivana Caputo. They are variously affiliated with the Department of Chemistry and Biology; and the European Laboratory for the Investigation of Food-Induced Diseases (ELFID) at the University of Salerno in Fisciano (SA), Italy



    Celiac.com Sponsor (A12):






    Celiac.com Sponsor (A12-m):




    Gluten is a protein found in wheat, rye and barley, and is the main factor implied in the onset of celiac disease, which involves both innate and adaptive immune responses to gluten. 

    The immune-triggering potential of some gluten sequences are increased by the deamidation of specific glutamine residues by type 2 transglutaminase (TG2), an enzyme whose expression is up-regulated in the intestine of celiacs. 

    The α-gliadin peptide 31-43 is a short gluten chain that resists intestinal proteases, and which seems to modulate TG2 function in the gut. Interestingly, TG2 can also influence the biological activity of this α-gliadin peptide 31-43. 

    A strong auto-immune response to TG2 is a classic sign of celiac disease. Auto-antibodies exert biological effects on multiple cells. These effects partly overlap with those caused by α-gliadin peptide 31-43. 

    In their recent review, the team poses a scenario in which TG2, anti-TG2 antibodies and peptide 31-43 come together to synergistically trigger and promote celiac disease. If their hypothesis is correct, further study could help researchers better understand celiac development and potentially point the way to new measures of prevention and/or treatment for celiac disease.

    Stay tuned for more articles on the role of TG2, anti-TG2 antibodies and peptide 31-43 in the development of celiac disease.

     

    Read more at Int J Mol Sci. 2020 May; 21(10): 3673

    Edited by Scott Adams

    0

    User Feedback

    Recommended Comments

    There are no comments to display.



    Guest
    This is now closed for further comments

  • About Me

    Scott Adams was diagnosed with celiac disease in 1994, and, due to the nearly total lack of information available at that time, was forced to become an expert on the disease in order to recover. In 1995 he launched the site that later became Celiac.com to help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives.  He is co-author of the book Cereal Killers, and founder and publisher of the (formerly paper) newsletter Journal of Gluten Sensitivity. In 1998 he founded The Gluten-Free Mall which he sold in 2014. Celiac.com does not sell any products, and is 100% advertiser supported.


  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-m):




  • Related Articles

    Jefferson Adams
    Celiac.com 11/04/2016 - Patients in the earliest stages of celiac disease have TG2-autoantibodies present in serum and small-intestinal mucosa. Many suffer abdominal symptoms long before the development of villus atrophy.
    The classic small-bowel mucosal damage that marks celiac disease develops over time and in stages; from normal villi to inflammation and finally to villus atrophy with crypt hyperplasia. Previously, researchers have shown that intraperitoneal injections of sera from celiac patients or of purified immunoglobulin fraction into mice trigger a condition mimics early-stage celiac disease.
    Those same researchers recently set out to show...

    Jefferson Adams
    Celiac.com 03/06/2018 - A number of clinicians and researchers have suspected that antibodies against transglutaminase 6 (anti-TG6) play a role in neurological issues in adult patients with genetic gluten intolerance, but it is not known if autoimmunity to TG6 develops after long-term consumption of gluten.
    A team of researchers recently set out to establish a correlation between these autoantibodies and the duration of gluten exposure by measuring the anti-TG6 in children with celiac disease at diagnosis. The team then investigated a correlation between anti-TG6 and the presence of neurological disorders.
    The research team included L De Leo, D...

    Jefferson Adams
    Celiac.com 03/28/2020 - In theory, celiac disease could be treated, and potentially cured, by restoring T-cell tolerance to gliadin. A team of researchers recently set out to investigate the safety and efficacy of negatively charged, 500 nm, poly (lactide-co-glycolide) nanoparticles encapsulating gliadin protein (TIMP-GLIA) in 3 mouse models of celiac disease. 
    The research team included Tobias L. Freitag, Joseph R. Podojil, Ryan M. Pearson, Frank J. Fokta, Cecilia Sahl, Marcel Messing, Leif C. Andersson, Katarzyna Leskinen, Päivi Saavalainen, Lisa I. Hoover, Kelly Huang, Deborah Phippard, Sanaz Maleki, Nicholas J.C. King, Lonnie D. Shea, Stephen D...

    Scott Adams
    Celiac.com 07/13/2020 - Celiac disease is a systemic disease that damages the small intestine and which, left untreated, can lead to numerous related health problems. The only treatment for celiac disease remains a gluten-free diet.
    Celiac disease is classified as an autoimmune disease in part because of the presence of anti-tissue transglutaminase 2 (anti-TG2) antibodies in the serum, as well as the presence of other autoimmune features. Anti-TG2 autoantibodies are produced in the intestines, and they show up there even before they begin to circulate in the blood.
    Researchers Mariantonia Maglio and Riccardo Troncone of the Department of ...