21858 Could that Canker Sore Mean Celiac Disease? - Celiac.com
No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter




Ads by Google:



Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts

SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Could that Canker Sore Mean Celiac Disease?

Celiac.com 07/16/2009 - A small but significant number of people who suffer from aphthous stomatitis, commonly called canker sores, also suffer from celiac disease, so it makes sense to perform celiac screening these people, according to a recent study that appears in BMC Gastroenterology.

Celiac disease is an inherited, immune system disorder in which the proteins found in wheat, rye and barley cause damage to the lining of the small intestine.

Reports suggest that canker sores might be the sole symptom for about one in twenty people with celiac disease, according to Dr. Farhad Shahram, of Tehran University of Medical Sciences, Iran, and colleagues.

Commonly called canker sores, aphthous stomatitis is a painful, open ulcer in the mouth that is white or yellow and surrounded by a bright red area. The sores often recur in times of stress and are associated with viral infections, food allergies and other complaints.

The research team looked at 247 people with aphthous stomatitis, who had suffered at least three aphthous lesions in the previous year. Subjects had a median age of 33 years.

The team screened blood samples for antibodies and other immune factors connected with celiac disease, and excluded patients with negative results. Subjects with positive blood tests underwent intestinal biopsy. A positive gluten-antibody blood test and abnormal biopsy results constituted gluten-sensitive enteropathy.

Ads by Google:

Of the 247 patients, seven patients showed positive blood tests and submitted for upper GI endoscopy and duodenal biopsy.

Two of the seven patients showed endoscopy results compatible with gluten-sensitive enteropathy, while five were normal. However, biopsy results for all seven showed gluten-sensitive enteropathy.

Average age for patients with gluten-sensitive enteropathy was 27 years old, and on average suffered from the disease for 4.5 years.

Interestingly, none of the seven celiac disease patients responded to conventional mouth ulcer medications, including topical corticosteroids, tetracycline, and colchicine.

Four of the seven patients with celiac disease adopted a gluten-free diet, and all four showed substantial improvement within 2 to 6 months.

As a result of the study, doctors should consider the possibility of celiac disease/gluten-sensitive enteropathy when treating patients for aphthous stomatitis patients, especially those who show a lack of response to conventional treatment, which may be another indicator of celiac disease risk.

BMC Gastroenterology 2009, 9:44

Celiac.com welcomes your comments below (registration is NOT required).





Spread The Word







Related Articles



18 Responses:

 
negativeserology
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
16 Jul 2009 3:14:40 PM PDT
hmm, negative blood tests only, huh?

 
Tracee
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
28 Jul 2009 10:18:54 AM PDT
This info needs to get out more! Canker sores and throat ulcers were my main symptom of Celiacs disease AND Crohn's. Gluten causes my mouth cankers and bakers yeast causes my severe throat ulcers. I had not had GI issues since childhood, which I seemed to outgrow, but suffered with severe cankers, as many as 9 at a time in my mouth. I would have never been diagnosed if it were not for trying a gluten free diet (the SCD) for my child's autism, my doctor thought I should give it a try myself when I mentioned it to him. The cankers went away! I was 41 years old and had spent years suffering, not to mention numerous doctor visits. I can always tell when I get a trace of gluten or yeast extract, I'll get a canker sore.

 
alan frank
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
02 Aug 2009 6:31:36 AM PDT
As a dentist (retired after 30+ years) and a sufferer of cancer sores for many years, I tried many remedies to no avail. I had numerous patients that had outbreaks much worse than mine.
Most had to "suck it up" and bear the pain. I researched out cures but never found anything in the literature (both medical and dental- I had full access to both the AMA and ADA web sites). I had been told they were from "stress". I was a long distance runner and noticed that after long workouts and hard training that they were more frequent. As I remember what foods that I was consuming after these workouts, I now realize that it was the huge quantities of gluten that caused the outbreaks.
My epithany came in July'05 when I was diagnosed with Celiac disease (age 62) and started my new gluten free diet. To date, I have not had a full blown outbreak, only small localized ulcers that heal within 1-2 days. (probably from contamination)
In the past, if I had bitten my lip, the ensuing ulcers would last at least 1 week, but now, they're gone by the next day.
Since I have retired, I no longer have access to these dental/medical sites and wonder if any articles have been written about the gluten intolerance/Celiac link to canker sores?? My dentist had no idea about the relationship after asking him at a recent visit.
Anyone that gets these sores in clumps, can be in so much pain that it is debilitating - unable to eat or drink.

 
Julie
Rating: ratingfullratingfullratingfullratingfullratingempty Unrated
said this on
23 Jan 2012 7:38:20 PM PDT
Thank you Dr. Frank. I am a dental asst who has suffered from these sores for almost ten years. I am in my late 30's. I think I have celiac disease. The dentist I used to work for laughed when I would have really bad sores. Like you said...in clumps. I wanted to die. He never had an answer. He would say I was just a freak. He thought it was all in my head. I have been taking a Zinc supplement for over a year now and it helps. They are no where near as bad as they used to be. Some of them used to take weeks to heal. Sometimes even months! Now they last about a week on the Zinc. I will give a gluten free diet a try. Thanks again for posting. You changed my life tonight.

 
Jen
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
10 Aug 2013 2:35:41 PM PDT
Oh girl, we're in the same situation. My doctor diagnosed that I have celiac disease and I'm two days on the gluten-free diet.

 
relivkris

said this on
15 Jul 2014 11:54:26 AM PDT
I too suffered from age 11 - 30 with cankers all over mouth and throat. unable to eat or swallow. I had NO cankers for 1 or 2 days per month. AGONY! Loss time at school and missed dentist apt due to pain. If I ate something that gave me cankers, I wouldn't eat that food again. Cankers are totally food related. I went gluten free ( tested neg for celiac per biopsy and blood test) I still had no cankers UNTIL I started eating snickerdoodle cookies from Enjoy Life. Gluten free, non gmo..etc.... those darn cookies give me cankers!

 
Brian
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
03 Aug 2009 9:49:18 PM PDT
I can add the missing (formerly common) canker sores to the laundry list of untreated symptoms that have cleared up magically on a gluten free diet. Biting my cheek at night clears in days not weeks. Some of mine were laterally symmetrical and other symptoms indicated Niacin deficiency in spite of eating adequate Niacin: poor absorption, can do that.

 
Jacqueline
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
28 Aug 2009 2:11:45 PM PDT
After being diagnosed with celiac disease by endoscopy three years ago, I have followed a gluten-free diet. I no longer suffer from the following: canker sores, cold sores, charlie horse leg cramps, rice krispie noises in my neck when I move my head side to side, constipation, bloating, and anemia. I have also helped three friends get diagnosed by describing my symptoms before I was diagnosed.

 
NanAsiaK
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
22 Jan 2012 8:27:42 AM PDT
Just a clarification. Almost all cold sores are caused by HSV1 (herpes simplex 1 virus) and could not/ would not go away due to a chande in diet. Cold sores and Canker sores are NOT the same thing.

 
Mary
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
01 Oct 2012 8:07:12 PM PDT
Thank you - that is exactly what happens to me!

 
Emery C
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
16 Jun 2010 4:48:11 PM PDT
This is a great article, It's well written and quite informative. It's known that there are no cures for canker sores. Over the counter products speed recovery and offer pain relief to make our lives less miserable. Canker sores can run in families and seem to follow certain age groups. Further studies in diets and personal hygiene may offer a good prevention program if certain individuals are prone to these sores.
Thanks for a great article.

 
Candace
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
10 Nov 2010 9:52:53 AM PDT
I've had canker sores all my life and just found out that I probably have Celiac disease and this is my only obvious symptom. I've found that avoiding toothpastes that contain sodium laurel sulfate really helps avoid outbreaks and the product Ulcer Ease helps with the pain when they do occur.

 
Marilyn
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
29 Jun 2011 12:08:52 AM PDT
My mom is 83 and started having canker sores (did not respond to treatment), anemia, vitamin D deficiency, terrible edema in legs, distended abdomen, hypoparathyroid with no known cause. They did a celiac panel (after I begged) and said she was negative. I just found out I have one celiac gene. I'm going to demand they test mom's...thanks for making this connection.

 
Kari
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
07 May 2012 12:04:34 PM PDT
I found out I have celiac disease and was diagnosed after having multiple mouth sore breakouts. Most of them were canker sores, but I also have the herpes virus. For me, eating gluten seemed to also depress my immune system. And then that can cause the herpes virus to come out of the nerves. Also, I would get ulcers from exposure to gluten inside of my mouth and severe bloating, stomach pain, and diarrhea. I thought the stomach pain was dairy for years, but I was not eating it and still had symptoms. I wish I had seen this article years ago. I am just so glad we were able to figure it out. I am gluten free, healthy, and happy today.

 
Gluten Freek
Rating: ratingfullratingemptyratingemptyratingemptyratingempty Unrated
said this on
06 Nov 2012 4:19:19 PM PDT
I have been gluten-free for 10 years, and I still get canker sores just as bad.

 
Bye Bye Gluten
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
22 Apr 2013 12:32:40 PM PDT
I've been searching for a solution for my mouth ulcers for over 40 years. Recently, my daughter was diagnosed with a sensitivity to gluten, so I stopped eating it out of solidarity. Voila, the ulcers are gone for several months now: something I don't remember in my entire adult life. Who'd have thought?

 
Kristen
Rating: ratingfullratingfullratingfullratingfullratingempty Unrated
said this on
15 Jul 2013 6:46:44 PM PDT
I stopped eating gluten for a period of 8 months and had no canker sores. After I began eating gluten again I didn't notice their appearance immediately, rather it has taken a little while, but they are back in full swing. I agree that gluten suppresses the immune system in some people and causes a myriad of other problems. Whether or not gluten is the direct or indirect cause of no canker sores I cannot say but it is definitely worth a try!

 
Jen
Rating: ratingfullratingfullratingfullratingfullratingempty Unrated
said this on
10 Aug 2013 2:44:35 PM PDT
I'm very thankful that I now know what causes my canker sores not to heal, instead just staying in my mouth every month and when the one heals comes the other... I don't like when my sores will be at my tongue its very painful and I can barely talk. But two days ago, my test was positive of celiac disease. I was so happy that now I know what triggers my canker sores, and on Tuesday i will go to my gastroenterologist doctor to have an endoscopy test. I have been to the hospital twice because I can't eat at all, my mouth and my throat was full of canker sores. I like to die in that time... but thank God there's always a way to find the cause of the problem. I'm still adjusting to what I eat and looking for gluten-free products in the shop. It's not so easy, but for my own good I will stick to my diet.




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:

All Activity
Celiac.com Celiac Disease & Gluten-Free Diet Forum - All Activity

That makes sense...I cried with relief when I got my diagnosis just because there was finally an answer. Please know that you are not weak or crazy. Keep pushing for testing. It could still be celiac, it could be Crohns. Push your Dr's to figure this out. Best wishes.

Thank you all very much. I actually cried when I got the answer. I wanted an explanation that I could "fix." Now I'm back to thinking I'm just weak and possibly crazy. I know I'm not crazy, but you know.

From what I have read online there is about a 1-3% chance of getting a false positive for celiac disease from a blood test. Was it a blood test that you got done? It may be worth your while to get a biopsy or more testing just to confirm it. I know being gluten free is a pain but it is better than getting cancer or other auto immune disorders.

I prefer edible candy. I have glaucoma and celiac so it helps me on a daily basis for all of my medical problems. I wish I could find a strain that has laxative effects so I didn't need linsess. Leafly.com has a lot of strain information and cannabist is a good resource, too. You can use CBD or THC and not get 'stoned'. I function fine on 20 mg of the candy. I refuse to drive if I smoke though. Good luck, hope it helps.

Is it NCGS or Low stomach acid misdiagnosed Low Stomach Acid and Celiac Disease Dear Gluten Intolerant please consider Low Stomach Acid as a possible Differential Diagnosis as a possible way to achieve remission of your GI symptom's. ?Consider what I say; and the Lord give thee understanding in all things? 2 Timothy 2: 7 Low stomach acid has now been linked to a probable cause of damage to the Small Intestine before and/or occurring with a Non-Celiac Gluten Sensitivity (NCGS) or Celiac diagnosis. See this research as reported on celiac.com that discusses the increased risk of/for someone to develop celiac disease after taking PPI?s. http://www.celiac.com/articles/23432/1/Do-Proton-Pump-Inhibitors-Increase-Risk-of-Celiac-Disease/Page1.html Note how the article starts quoting ?Rates of celiac disease and the use of drugs to inhibit the secretion of stomach acid have both increased in recent decades. A research team recently set out to explore the association between anti-secretory medication exposure and subsequent development of celiac disease.? If these medicine are lowering stomach acid what cause effect relationship does/ could this have on Celaic/NCGS diagnosis is what he is postulating. He goes on to say without being very technical (read the whole article for yourself) that ?The data clearly show that patients who use anti-secretory medications are at much greater risk for developing celiac disease following the use of these medicines. The fact that this connection persisted even after the team excluded prescriptions for anti-secretory medicines in the year preceding the celiac disease diagnosis suggests a causal relationship?. If even after a year OFF these medicines your chances of developing Celiac Disease (celiac disease) not to mention even NCGS which is much more prominent surely the researcher is correct in postulating that there is a cause and effect relationship between low stomach acid and NCGS and/or Celiac disease. Surely there is something we can learn here. I now postulate some homework for the reader of this blog post. Do some research for yourself and see if achlorhydia or hypochlorhydia symptoms don?t at least resemble in some manner all of the GI symptoms you have been having. (I note some of the many symptom?s low stomach acid can present with below as referenced from Dr. Myatt?s online article ?What?s Burning You? for easy reference (It might not be what you think (my words)) It is important to note here that ?some? symptoms does not mean all but many or several. It is called a differential diagnosis. It is an important diagnostic tool in medicine. Think of the tv show ?House? where they spend the whole hour/over a week times going through the ?differential diagnosis? in short any one symptom can/have many different causes. The trick is how to quickly eliminate possible outcomes as symptoms (many) go up. All is usually never meet because that would make the disease in full outbreak and obvious even to the layman a condition described as ?frank? or ?classic? Scurvy or Rickets as an example. Sadly too often after 8 to 10+ years of testing after all the differential diagnosis?s are ruled out you are said by process of elimination to have Celiac Disease if you are lucky or maybe NCGS and not some other acronym GI disease as I like to refer to them as a group. GERD,IBS,UC, Chrons etc because if they turned down that street ? . you are/could be in/at a dead end for they stop looking at the trigger (gluten) as the cause of your gastric upset/digestive disorder(s). So in summary if 3 or 4 or 5 or 6 of these symptoms overlap ?many of? these symptoms could be Low Stomach Acid related. IF that is the cause/case for you then there is hope! For remission! From Dr. Myatts? Online article what?s burning you? From Dr. Myatts? Online article what?s burning you? http://healthbeatnews.com/whats-burning-you/ Diseases Associated with Low Gastric Function Low stomach acid is associated with the following conditions: * Acne rosacea * Addison?s disease * Allergic reactions * Candidiasis (chronic) * Cardiac arrhythmias * Celiac disease * Childhood asthma * Chronic autoimmune hepatitis * Chronic cough * Dermatitis herpeteformis * Diabetes (type I) * Eczema * Gallbladder disease * GERD * Graves disease (hyperthyroid) * Iron deficiency anemia * Laryngitis (chronic) * Lupus erythromatosis * Macular degeneration * Multiple sclerosis * Muscle Cramps * Myasthenia gravis * Mycobacterium avium complex (MAC) * Osteoporosis * Pernicious anemia * Polymyalgia rheumatica * Reynaud?s syndrome * Rheumatoid arthritis * Scleroderma * Sjogren?s syndrome * Stomach cancer * Ulcerative colitis * Vitiligo When low in stomach acid we become low in essential nutrients Quoting from Dr. Myatts ?what?s burning you? online article ?Our bodies need 60 or so essential nutrients. ?Essential? means that the body MUST have this nutrient or death will eventually ensue, and the nutrient must be obtained from diet because the body cannot manufacture it. Many of these essential nutrients require stomach acid for their assimilation. When stomach acid production declines, nutrient deficiencies begin. Calcium, for example, requires vigorous stomach acid in order to be assimilated. Interestingly, the rate of hip replacement surgery is much higher in people who routinely use antacids and acid-blocking drugs. We know that people who have ?acid stomach? were already having trouble assimilating calcium from food and nutritional supplements due to lack of normal stomach acid production. When these symptoms are ?band-aided? with drugs which decrease stomach acid even more, calcium assimilation can come to a near-halt. The result? Weak bones, hip fractures and joint complaints resulting in major surgery. Jonathan Wright, M.D., well-known and respected holistic physician, states that ?Although research in this area is entirely inadequate, its been my linical observation that calcium, magnesium, iron, zinc, copper, chromium, selenium, manganese, vanadium, molybdenum, cobalt, and many other micro-trace elements are not nearly as well-absorbed in those with poor stomach acid as they are in those whose acid levels are normal. When we test plasma amino acid levels for those with poor stomach function, we frequently find lower than usual levels of one or more of the eight essential amino acids: isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine. Often there are functional insufficiencies of folic acid and/or vitamin B12.? Remember, these are essential nutrients. Deficiencies of any single one of them can cause serious health problems over time. Weak bones, diminish immune function, failing memory, loss of eyesight and many other ?diseases of aging? are often the result of decreased stomach function.? It is me again reader. So low stomach acid is the triggering agent (often) for low nutrients. Make too much sense! Now don?t take Vitamin?s for this condition where low Vitamins/Minerals are known to be low in patients who have this condition because . . . . (if you do you won?t need to keep coming back to the doctor) I can almost hear the doctor say now. Of course he/she doesn?t say that . . . just that the ?average person? doesn?t need to take Vitamins. Well I hate to break it too you . . . . but if you are having GI problems and reading this blog post on celac.com then you are not the ?average? person. You my friend or a sufferer or a friend of a sufferer still looking for answers. If that is you then consider taking either powdered stomach acid ? Betaine HCL or taking Niacinamide to help you reset your stress clock. A Canadian researcher wrote about this connection 15+ years ago but still most doctors? don?t understand this connection between about how ?Niacin treats digestive Problems? Here is the full link so you can research it more yourself. http://orthomolecular.org/library/jom/2001/articles/2001-v16n04-p225.shtml And you might not after a first reading. I didn?t believe it myself for over a year . . . but every time I thought about it ? it (Low Stomach Acid) made/makes the most sense to me. **** Note: research this yourself. Here is a link about how to take Betaine HCL (powdered stomach) for maximum effectiveness. http://20somethingallergies.com/how-much-hcl-do-i-take-learn-to-test-for-your-correct-dose/ Don?t take my blog post as medical advice. It is only what I did . . . it might not work for you but I think it is worth a try especially if you are not now taking an acid reducer. (see notes below about why this might) be more difficult if you are already taking an acid reducer . . . because the rebound wall (see chris kresser link) keeps us locked in . . . sometimes for years. Since I was not taking acid reducers at the time I took Betaine HCL my stomach problems improved and I am sharing this now in the hopes it might help yours too! Now back to (really) LOW stomach acid being diagnosed as HIGH stomach acid these days. How can we know if it truly high or low? You?ve heard the phrase timing is everything well it is here too! Timeline is important in any diagnosis. IF your stomach acid was HIGH as you often hear (everywhere) you hear take a Proton Pump Inhibitor aka acid reducer?s for heartburn/GERD (medical name for heartburn) then eating food (carbs, greasy things) wouldn?t bother you. The acid would cut it up but if it is already low/weak then even a little acid can burn your esophagus which is not coated like the stomach to protect you from high acid. BUT if it is low to start with then food will WEAKEN our/your acid so that you lose the food fight your in and things (carbs/fats) become to ferment, rancidify and cause heart burn. Leading in time to Non-Celiac disease first and with enough injury (and time) to Marsh lesions qualifying you for diagnosis as a Celiac candidate / patient. See above link between/about PPI?s in the year preceding a Celiac diagnosis. If you (can) be that patient and weight the xx number of years for all this damage to occur, there is a better way it is called digestion! A virtuous cycle can replace the vicious cycle you are now in ? it is caused digestion. Digest your food with healthy stomach acid and your body will thank you for it with the God given burp. A healthy child burps (at 6 months of age normally) and a healthy adult should too and you will again after taken Niacinamide 3/day for 6 months or this is not the right diagnosis. *********Note this is not medical advice only my experience with Niacinamide and my many years researching this topic as a fellow sufferer. Let me make these disclaimer(s). If you are a) experiencing heartburn that causing vomiting (with unintended weight loss) you may have a special case of heartburn that feels like heartburn (on steroids) that is really Bile Reflux and taking Stomach is not something you should do without medical advice and supervision. See this NYtimes article that discusses the many complications often seen with Bile Reflux patients and why it is treated as Heartburn often and why Bile Reflux is especially hard to recover from. http://www.nytimes.com/2009/06/30/health/30brod.html you are already taking an acid reducer then the chance you will get better (off of acid reducers completely) is only 50/50 on your first try but going low CARB can help your transition. Otherwise most people will get better when taking BetaineHCL for gastric support and Niacinamide to help them/you reset your digestive processes. See this online article about how Jo Lynne Shane got off Nexium for good. http://www.jolynneshane.com/how-i-got-off-nexium-for-good.html and her Epilogue http://www.jolynneshane.com/epilogue.html You will see she still struggles some but is much better when she let her natural digestive juices do their job. I call it the ?Natural Order of Things?. See this article about the digestion process being a North South Affair from the bodywisdom website http://bodywisdomnutrition.com/digestion-a-north-to-south-process/ Taking it (Niacinamide) (or any B-Vitamin) should be taken 2 to 3/day (too keep up serum levels) for 3 to 4 months (the time you can store B-Vitamins) in the liver mostly. Once you have a distinctive BURP that displaces the bloating and sense of ?I am going to explode? if I eat another bite (though you haven?t eaten half your meal) then normal digestion is occurring again. If you stool did not sink before this process (of taking Niacinamide begun) and burping became your ?new normal? then it (your stool) will begin to sink too! Burping without bloating is the ?Natural Order? of good digestion. Don?t stop this process of taking B-Vitamins as Niacimaide or Slo-Niacin 2/day for at least 4 months then you should see most of your GI symptom?s go into remission. (I did not say "cure" but remission from your cross contamination's (flares/symptom's etc.) might be possible. Because our defenses are now strong enough to cut up proteins before they reach our small intestine (where most of the damage is done). Think of a castle with a moat around it (stomach acid is designed to protect us) when it is low (the moat doesn?t protect us) and when the moat is dry the castle becomes a ruin!!! So do proteins (lactose (casein), gluten, soy, seafood etc.) to our small intestines (they become ruined) when our stomach acid (moat) is low or worse dry! I repeat again Timeline is important in any diagnosis. All heartburn is not equal. IF your stomach acid is truly high then it WILL occur between meals when there is no food to tamp down the fire (occurring in your stomach) not your esophagus. The excess pressure from fermented carbs push open the trap door allowing the low acid you have to burn the lining of your uncoated esophagus. See also this online article by Chris Kresser to study this more about why/how this could be a case of medical misdiagnosis in more detail https://chriskresser.com/what-everybody-ought-to-know-but-doesnt-about-heartburn-gerd/ This is part of a 3 part series that I think you will find very informative. This (low stomach acid) is a vicious cycle. STRONG stomach acid makes it a virtuous circle/cycle. Now food benefits you because low acid not only causes heartburn it limits your body?s absorptive ability by limiting its ability to cut up your food into digestible peptides and amino acids which are no longer harmful to your Small Intestine but helpful to your overall health because nutrients can now be absorbed because the food particles are now small enough to not cause harm to your villi. I hope this is helpful and it helps you the way it helped me. Maybe it will help you in a similar manner. I write this only as a guidepost on your way. May you find your way back to digestive peace! The ?Natural Order? of things! Praise bee to God! It is not a long way if you know the way . . . . from someone who has found his way back God being his help! There are more things I could say . . . but this post is getting kind of long but you get the gest. I noticed someone else on the celiac.com noticed the same improvement when they treated their low stomach acid and thought it was time a blog post talked about it. It is so much easier to consume all this information in one setting instead of hunting and peeking through several thread posts. Search for the posterboy on celiac.com and you will find it is my focus (how low stomach acid is misdiagnosed) and how Niacinamide helped me to restore its ?Natural Order? in the digestive process because it helped me! Here is the link to the Prousky?s abstract. 15+ years is a long time for people to continue to suffer but if the research it right then Niacinamide might help you too! http://www.yourhealthbase.com/database/niacin-treats-digestive-problems.htm Let?s hope it is not another 15 years before doctor?s and people realize low stomach acid can explain many of the same symptom?s an IBS, NCGS or even a Celiac patient might experience given a long enough time for these conditions to develop from too low a stomach acid to protect our Small Intestine. See link at start of this blog post posted here again for convenience. http://www.celiac.com/articles/23432/1/Do-Proton-Pump-Inhibitors-Increase-Risk-of-Celiac-Disease/Page1.html And it is worth noting about the time Celiac disease started (began to be more prevalent) / to increase in the population Acid reducer?s became more and more popular. *** Some plot the increase in time to Roundup usage but I am not buying it. PPI?s increase seam more plausible to me based on the relatively new research (less than 5 years old) is pretty current by research standards and the near linear response to increased first H2 stomach acid reducer?s then PPI?s in the population at large. *****Note: after I finished writing this blog post new research that in my mind confirms this connection was reported on celiac.com today that notes the link between gastric pH and impaired nutrient absorption. This very topic as I was getting ready to publish my post about low stomach acid possibly being diagnosed as Celiac disease on my posterboy blog mentions how a Celiac patient?s absorption can be impaired by gastric pH. https://www.celiac.com/articles/24738/1/Can-Celiac-Disease-Impair-Drug-Therapy-in-Patients/Page1.html Where they (researchers) say/ask discussing Celiac Disease and whether it (celiac disease) can impair drug therapy in patients. Note the opening paragraph discussing this topic quoting ?Celiac disease is associated with numerous chronic conditions, such as anemia and malabsorption of some critical vitamins. Changes in the gastrointestinal tract, rates of gastric emptying, and gastric pH are responsible for impaired vitamin and mineral absorption." i.e., low gastric pH can effect absorption. It stands to make reasonable sense to me they are related conditions and one is being diagnosed for the other often or at least one is being confused as the other and treating one (raising your stomach pH) might treat the other since many of the symptoms? are the same. *** this/these opinion(s) are my own and do not reflect an endorsement by celiac.com of these ideas, comments, thoughts or opinions. I hope this helps! You the way it did me! Good luck on your continued journey, Remember **** This is not medical advice and should not be considered such. Results may vary. Always consult your doctor before making any changes to your regimen. 2 Timothy 2:7 Consider what I say; and the Lord give thee understanding in all things. Posterboy by the Grace of God,