No popular authors found.


Get Celiac.com's E-Newsletter

Categories

No categories found.







Ads by Google:


Questions? Join Our Forum:
~1 Million Posts
& Over 66,000 Members!



SHARE THIS PAGE:
Celiac.com Sponsors:

Saliva Screening for Anti-transglutaminase Autoantibody Effective for Diagnosing Celiac Disease in Children


New celiac saliva screening study in JPGN.

Celiac.com 12/13/2010 - Driven by the high prevalence of celiac disease, a team of researchers based in Italy to assess a new, noninvasive disease screening strategy that would allow them to make an early diagnosis of celiac disease in 6- to 8-year-old children.

Timely diagnosis will help doctors to initiate a gluten-free diet in willing patients, achieve growth targets, and prevent celiac disease complications.

For the study, the research team recruited 5000 subjects, and ultimately tested 4048 saliva samples for anti-tissue transglutaminase (tTG) and immunoglobulin (Ig)A using fluid-phase radioimmunoprecipitation.

For children with positive samples, the team arranged follow-up screening by serum radioimmunoassay tTG IgA, enzyme-linked immunosorbent assay tTG IgA, and anti-endomysium IgA. Children with positive serum assays underwent endoscopy with duodenal biopsies, and researchers advised those diagnosed with celiac disease to start a gluten-free diet.

The team gained screening consent from 4242 parents (84.8%), and obtained usable saliva samples from a total of 4048 children (95.4%). Thirty-two children showed positive salivary tTG IgA, with another nine showing borderline autoantibody results.

Ads by Google:

Thirty-one of the 32 tTG IgA-positive subjects, and three of the nine borderline subjects also had positive blood screens. Intestinal biopsy showed twenty-eight children with villous atrophy, while one child showed Marsh 1 lesions. The research team recommended a gluten-free diet to three children without performing endoscopy.

This makes for a celiac disease rate of 1.16% in the study population, including 19 known cases of celiac disease.

The results show that screening detected three cases of celiac disease for every two cases diagnosed before screening was 3:2. The ratio between symptomatic and asymptomatic patients was 1:1.6.

The study shows that saliva screens for celiac disease can be  effective in identifying celiac disease early in childhood.

Also, for this study at least, the data shows full compliance with gluten-free diet in the children diagnosed with celiac disease.

Source:


Celiac.com welcomes your comments below (registration is NOT required).












2 Responses:

 
Rose Johnson
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
03 Apr 2012 5:44:29 AM PST
Early screening in children is imperative and will lead to better quality of health in adulthood.

 
Stephanie
Rating: ratingfullratingfullratingfullratingfullratingempty Unrated
said this on
28 Sep 2012 1:53:08 PM PST
I've been pursuing a diagnosis for my daughter's symptoms since she was 2 years old. I didn't suspect celiac disease until she was 6. That was the point when she was able to describe what she was feeling. Prior to that, she had chronic cyclical vomitting, lethargy, stomach aches, ADD behaviors. I was told repeatedly that she was "doing it for attention". After going gluten-fee, it was a mere 2 weeks later when she came bounding down the stairs to breakfast and announced that her tummy didn't hurt anymore! Her celiac disease tests were negative until she was 11. I would love to see this method of testing put into practice with every child. So simple!




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


Thanks Ennis!

There is light at the end of the tunnel. Like GFinDC said, the recovery time after a gluten exposure can vary due to so many different variables. I hope your recovery is fast! ?

Welcome to the forum. Thank you for sharing your story. I am sorry that you have had to suffer for so long. Celiac disease is so frustrating and still people (and that includes medical) are not aware if it. Thank goodness for that home test kit. I hope your recovery is swift! Please f...

Hi Arduaine, Welcome to the forum! Glutenings can cause different symptoms in people. When you are new to the gluten-free diet and early in the recovery, they may cause more intense symptoms than later. Most likely because your immune system is already in a heightened state of alert f...

Sales on many places https://www.christopherbean.com/collections/flavored-coffee Desert flavored coffee,,,,yeah it is that epic, check out my reviews on some of them under Ennis, they are dead on to the cupping notes with a bit of sweetener. Use SAVE10 for a bonus $10 off your cart. YOU will be...