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Have Researchers Finally Nailed Down Non-celiac Gluten Sensitivity?

Celiac.com 01/13/2016 - Researchers are zeroing in on markers for gluten sensitivity in people who don't have celiac disease.

Photo: CC--Derek GaveySo far, there's been scant proof of what causes gluten sensitivity in people who don't have celiac disease. It's been difficult to even pin down the existence of a condition that can be tested and diagnosed.

The results of a recent study may change that. The study, from Giovanni Barbara and his team at the University of Bologna, Italy, suggests that inflammation in gluten-sensitive individuals may result from high levels of a molecule called zonulin.

Zonulin has been linked to inflammation, and people with celiac disease have been shown to have high levels of zonulin when consuming wheat protein. Symptoms include abdominal pain, bloating, alternating diarrhea or constipation. And there can be other symptoms, including "brain fog," headache, fatigue and joint and muscle pain.

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Barbara's study found that zonulin levels in gluten-sensitive individuals almost matched those of celiacs.

The researchers stress the preliminary nature of the results, but note that this information could lead to testing methods for detecting gluten sensitivity in people who don't have celiac disease.

According to gastroenterologist Alessio Fasano of Massachusetts General Hospital in Boston, about 6 percent of the global population may be sensitive to gluten, so any breakthrough in identifying and testing for non-celiac gluten sensitivity could impact tens of millions of people worldwide.

Stay tuned for more on zonulin and it's role in non-celiac gluten sensitivity. 

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1 Response:

 
Diana
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said this on
19 Jan 2016 6:37:12 AM PDT
Good news that something tangible has been identified for those of us who are gluten-sensitive and KNOW we have an issue when eating wheat products. My primary symptom is headache. The inflammation effect would explain why. The article specifically says 'wheat'. I wonder if this zonulin link applies to other substances such as rye or barley.




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We freeze portions in a regular freezer zip lock bag.

That sounds good. Do you have a machine that seals without air or do you just use bags? Is it possible to buy bags only? I remembered the other type of froz food I sometimes get - Saffron Road.

You can always check to see how long the lab order lasts, if you'd like to continue eating gluten longer.

Might be something else in there, perhaps he ate something else with gluten, something was mixed in the chips, the chips were flavored or in a snack mix with pretzels. I get that way with gluten, but the last 2 times the gut issues render me unable to argue like that but I do go Mr. Hyde like =. ...

I hate to say it and be Mr. Negative ass here. But I had this exact same thought about having kids, I do not wish any kids I have to have my AI issues, and decided I would wait a few decades if need be for the new gene editing things they are working on so we can have them changed. Call me crazy.