No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Is Reflux Involved in Esophageal Mucosal Changes in Active Celiac Disease Patients?

Celiac.com 04/20/2016 - People with celiac disease very often have reflux symptoms. A team of researchers recently set out to evaluate mucosal integrity and motility of the lower esophagus as possible contributors to reflux symptoms in patients with celiac disease.

Photo: CC--Jacinta Illuch ValeroThe research team included María Inés Pinto-Sánchez, Fabio D. Nachman, Claudia Fuxman, Guido Iantorno, Hui Jer Hwang, Andrés Ditaranto, Florencia Costa, Gabriela Longarini, Xuan Yu Wang, Xianxi Huang, Horacio Vázquez, María L. Moreno, Sonia Niveloni, Premysl Bercik, Edgardo Smecuol, Roberto Mazure, Claudio Bilder, Eduardo C. Mauriño, Elena F. Verdu, and Julio C. Bai.

They are variously affiliated with the Farncombe Family Digestive Health Research Institute at McMaster University, in Hamilton, Ontario, Canada, the Department of Medicine, "Dr. Carlos Bonorino Udaondo" Gastroenterology Hospital in Buenos Aires, Argentina, Favaloro University Hospital in Buenos Aires, Argentina, Consejo de Investigación en Salud, MSAL, Gobierno de la Ciudad Autónoma de Buenos Aires, Argentina, and with the Gastroenterology Chair, Universidad del Salvador in Buenos Aires, Argentina.

For their study, they enrolled newly diagnosed celiac disease patients with and without reflux symptoms, non-celiac patients with classical reflux disease (GERD), and control subjects, who had no reflux symptoms.

Using both light microscopy and electron microscopy, they assessed endoscopic biopsies from the distal esophagus for dilated intercellular space (DIS). They used qRT-PC to determine tight junction (TJ) mRNA proteins expression for zonula occludens-1 (ZO-1) and claudin-2 and claudin-3 (CLDN-2; CLDN-3).

Ads by Google:

Overall, patients with active celiac disease showed higher DIS scores than controls, and similar to GERD patients. They found altered DIS even in celiac disease patients without reflux symptoms, who had normalized after one year of a gluten-free diet.

Celiac disease patients with and without reflux symptoms had lower expression of ZO-1 than controls. Celiac disease and GERD patients showed similar expression of CLDN-2 and CLDN-3.

This study shows that patients with active celiac disease have altered esophageal mucosal integrity, independent of any reflux symptoms.

Loss of TJ integrity in the esophageal mucosa may result from altered expression of ZO-1, which may contribute to the development of reflux symptoms.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



6 Responses:

 
bryan
Rating: ratingfullratingfullratingemptyratingemptyratingempty Unrated
said this on
25 Apr 2016 3:34:32 PM PDT
These articles might be beneficial if a layman could actually understand what is being said.....

 
jack
Rating: ratingfullratingfullratingemptyratingemptyratingempty Unrated
said this on
27 Apr 2016 2:17:30 PM PDT
I agree. Even being a nurse, I was challenged to understand what was being said.

 
Mark
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
25 Apr 2016 6:39:32 PM PDT
Excellent!!!!
Perhaps all celiacs could pass this on to their on to their gastro!
THANK YOU!

 
Shirley
Rating: ratingfullratingfullratingemptyratingemptyratingempty Unrated
said this on
26 Apr 2016 11:44:07 AM PDT
I agree with Bryan. It would be great if a layperson such as myself could understand these reports.

 
Dawna
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
26 Apr 2016 1:00:43 PM PDT
I figured as much.

 
Christie
Rating: ratingfullratingfullratingfullratingemptyratingempty Unrated
said this on
03 May 2016 7:44:24 AM PDT
If you could understand all that was being said it would be great! However it seems as if the GERD I currently have is due to my celiac , also I know now that the Nexiym I've been taking is also causing malabsorption issued as well..... My BIG question would be , OK , now they have figured this out ...WHAT can we do about it ???




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


There are plenty of people that have gone gluten free without the official diagnosis because a gluten challenge would make them too sick. I think you are the only one that will know if it's right for you. There are some benefits to getting diagnosed as either celiac or NCGS. 1. If you are...

Oh, I would hate to have you test negative because your gluten challenge was not long enough. http://www.cureceliacdisease.org/faq/what-is-a-gluten-challenge/ https://www.beyondceliac.org/celiac-disease/Testing-and-Diagnosis/The-Gluten-Challenge/1510/ https://www.ncbi.nlm.nih.gov/p...

thank you guys. I'm hoping the Gi will call back tomorrow. I'm getting the kitchen totally gluten free, except for a few things my sister who is a bit disabled is going to have. But no bread, flour, pasta and most other things will not have gluten. And my daughter doesn't go to school, she d...

Unprocessed food is great, but a life without chocolate no way! Am sure you will find a suitable brand. I don't eat Lindt, think they may use barley, others may know more. The Moser Roth are Aldi own brand. Looks like Aldi aren't in CR so not an alternative for you sorry. Maybe chec...

Ok guys, I'm not an expert. Maybe it was really just cc as Matt said. Or my body is just too sensitive now and this thing is too artificial/chemical. I feel that real unprocessed food is better for me now. It won't be a problem to find another brand. The Moser Roth doesn't sound familiar t...