No popular authors found.


Get Celiac.com's E-Newsletter

Categories

No categories found.







Ads by Google:


Questions? Join Our Forum:
~1 Million Posts
& Over 66,000 Members!



SHARE THIS PAGE:
Celiac.com Sponsors:

Study Hints at Connection Between Celiac Disease and Certain Viral Infections


Photo: CC--Todd Chandler

Celiac.com 07/28/2016 - Celiac disease is an immune-mediated enteropathy triggered by gluten in genetically susceptible individuals. Researchers know that innate immunity plays a role in triggering celiac disease, but they don't understand the connection very well at all.

Although previous in vitro work suggests that gliadin peptide p31-43 acts as an innate immune trigger, the underlying pathways are unclear and have not been explored in vivo.

The research team included RE Araya, MF Gomez Castro, P Carasi, JL McCarville, J Jury, AM Mowat, EF Verdu, and FG Chirdo. They are variously affiliated with the Instituto de Estudios Inmunológicos y Fisiopatológicos (IIFP)(CONICET-UNLP), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina; the Catedra de Microbiología, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina; the Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada; the Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, Scotland, United Kingdom; and with the Instituto de Estudios Inmunológicos y Fisiopatológicos (IIFP)(CONICET-UNLP), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina.

Ads by Google:

Their team observed that introduction of p31-43 into the gut of normal mice causes structural changes in the small intestinal mucosa consistent with those seen in celiac disease, including increased cell death and expression of inflammatory mediators. The effects of p31-43 were dependent on MyD88 and type I IFNs, but not Toll-like receptor 4 (TLR4), and were enhanced by co-administration of the TLR3 agonist polyinosinic:polycytidylic acid.

Together, these results indicate that gliadin peptide p31-43 activates celiac-related innate immune pathways in vivo, such as IFN-dependent inflammation.

These findings also suggest a common mechanism for the potential interaction between dietary gluten and viral infections in the pathogenesis of celiac disease, meaning that certain viral infections may pave the way for celiac disease to develop.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



2 Responses:

 
coloradosue
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
03 Aug 2016 1:59:44 PM PST
Duh!!!! My celiac disease was turned on when I was exposed to a virus my boss (he refused to stay home when he was running a fever and coughing violently) that had infected me and became double pneumonia. Once the virus had run it's course, in about two weeks, I had my first experience with CD. My adult daughter 8 months later was diagnosed with CD after exposure with a kidney infection. Her young son was diagnosed with CD after exposure to bad virus. Definitely a pattern here!

 
Grandma
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
13 Sep 2016 9:06:31 AM PST
Can a virus affect a "genetic" celiac diagnosis? If a genetic diagnosis is given does that mean both parents carry the gene at same time or only parent parent? Or is it a recessive gene from both parents. Or is this still unknown?




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


The casein in milk is very similar to the gluten protein, and over time the ammune system can react to the casein as though it was gluten. This happens over time, and though you may have been able to consume dairy previously, you may have to avoid it now. Not good to suffer the consequences, it ...

Hi everyone! I am new to this forum (in the testing stages) and was wanting to get a second opinion on my blood panel results. My alkaline phosphatase levels were flagged as low, mine are at 30 with the normal range being 34-130. Has anyone else experienced this problem before being diagnosed as ...

The current gluten-free trend, the one Russ was hesitant of being associated with, has been a double-edged sword for those with celiac disease, according to Talia Machlouf, the director of advocacy and research for the Celiac Disease Foundation. On one hand, it was not long ago when gluten-free ....

Sticking to a gluten-free diet is very important, but it can also be a challenge. Enter the MyHealthyGut app, which monitors gastrointestinal symptoms like the ones associated with Celiac Disease. The app allows you to track symptoms side-by-side with a food diary. This helps sufferers determine ...

The overall prevalence of NCGS in the general population is still unknown, mainly because many people self-diagnose and begin a gluten-free diet without medical ... However, in order to confirm a person may have a sensitivity to gluten, doctors must first rule out wheat allergy and celiac disease...