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Does Candida Albicans Trigger the Onset of Celiac Disease?

Lancet. 2003 Jun 21;361(9375):2152-4.

Celiac.com 08/25/2003 – This interesting study compares a specific amino acid sequence found in Candida cell wall protein to a the gliadin amino acid sequence that triggers the immune response in celiac disease. The researchers found that the sequences are "identical or highly homologous to known coeliac disease-related alpha-gliadin and gamma-gliadin T-cell epitopes," and propose that Candida is the trigger for the onset of celiac disease. Below is the abstract for this study.

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Is Candida albicans a trigger in the onset of coeliac disease?
Nieuwenhuizen WF, Pieters RH, Knippels LM, Jansen MC, Koppelman SJ.

Coeliac disease is a T-cell-mediated autoimmune disease of the small intestine that is induced by ingestion of gluten proteins from wheat, barley, or rye. We postulate that Candida albicans is a trigger in the onset of coeliac disease. The virulence factor of C albicans-hyphal wall protein 1 (HWP1)-contains amino acid sequences that are identical or highly homologous to known coeliac disease-related alpha-gliadin and gamma-gliadin T-cell epitopes. HWP1 is a transglutaminase substrate, and is used by C albicans to adhere to the intestinal epithelium. Furthermore, tissue transglutaminase and endomysium components could become covalently linked to the yeast. Subsequently, C albicans might function as an adjuvant that stimulates antibody formation against HWP1 and gluten, and formation of autoreactive antibodies against tissue transglutaminase and endomysium.

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5 Responses:

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said this on
06 Jan 2012 7:54:40 PM PDT
Very interesting to know, why do the doctors not make the connection?

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said this on
17 Jul 2012 5:22:34 AM PDT
Before being recently diagnosed with celiac disease, I spent quite a few years with symptoms of Candida which I had to research myself and try to convince doctors that my symptoms were not anxiety or depression related. I did not need therapy or more drugs to fix it. My symptoms were real, and I usually got very laid back, vague responses. I couldn't get anyone to take it serious and felt like a hypochondriac. It wasn't until my symptoms got progressively worse in the last 4 years to the point where I had to request a celiac (from a new doctor) test as a last resort did I finally get help. I would say the whole process took ten to fifteen years from the time I noticed the first symptoms. A few weeks ago I actually mentioned this to my nutritionist if there was a connection. So this proves my theory! It was not something she was aware of for sure.

Beauty and the Yeaast
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said this on
26 Aug 2012 11:26:57 AM PDT
I too have suffered for YEARS with Candida and Celiac. Here's my full story, and I'm so thankful to see that the connection has been made by others as well.

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said this on
30 Apr 2015 6:43:50 AM PDT
I too have for many years suffered and been told that I have Candida Albicans in my body. Meaning stomach, blood stream, intestines etc..
All the doctors that I saw waved off the condition as not possible unless I had been deathly sick like with Cancer and such. I read "The Yeast Syndrome" many years ago and stopped handing over my money to doctors who would give me no reason accept for depression.
Now that I am older the condition had worsened so that I went to a G.I. who ran tests and concluded that I had Irritable Bowel Syndrome.
Finally, He began, after almost a year, to consider the possibilities of celiac disease. I have not yet been diagnosed, still in the testing stages, but since my cousins all have it I am thinking I am a prime candidate. I totally understand people's frustration about getting so many tests and then diagnosis is a guess at best.

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said this on
06 Sep 2012 3:11:22 PM PDT
This is 100% accurate, and if you clean the candida the gluten sensitivity is gone.

The reason the medical industry doesn't tell you about it, is because people will wonder what caused the naturally occuring candida, to overgrow. Then they would see it's the antibiotics, or meat and dairy products (filled with antibiotics). Once you ingest any of these 3 forms of antibiotic, even just one time, your good bacteria all dies from your gut, and candida then overgrows.

So of course they wouldn't want a similar reaction to antibiotics. Once people catch on just like they did with the autism vaccine link.

They feel it doesn't matter if you know this truth or not, because the benefits (their fattening pockets) outweigh the risks (your death or ill health)

Also candida cleanses won't work because they only clear the candida in the gut and wont address the candida that became fungus and spread along the body. Only Jeff McCombs cleanse is proven to clear the entire body. It is a difficult cleanse I know, but it is worth it. Do it and feel better than you have in years!

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Wish I could give you a hug. Unfortunately I know how that feels with Neurologists, Internists, Endocrinologists, Rheumatologists, GIs..... I got so tired of crying my drive home after refusing yet another script for Prozac. I do hope your GI can give you some answers even if it is just to rule out other possible issues. Keep on the gluten and we are here for you.

It is too bad that so often a full panel isn't done. Glad your appointment got moved up and hopefully you will get a clearer answer from the GI. Do keep eating gluten until the celiac testing is done. Once the testing is done do give the diet a good strict try. Hang in there.

That makes sense...I cried with relief when I got my diagnosis just because there was finally an answer. Please know that you are not weak or crazy. Keep pushing for testing. It could still be celiac, it could be Crohns. Push your Dr's to figure this out. Best wishes.

Thank you all very much. I actually cried when I got the answer. I wanted an explanation that I could "fix." Now I'm back to thinking I'm just weak and possibly crazy. I know I'm not crazy, but you know.

From what I have read online there is about a 1-3% chance of getting a false positive for celiac disease from a blood test. Was it a blood test that you got done? It may be worth your while to get a biopsy or more testing just to confirm it. I know being gluten free is a pain but it is better than getting cancer or other auto immune disorders.