Celiac.com 04/16/2019 (originally published 04/24/2008) - Genetic tests for celiac disease and gluten sensitivity are readily available. Testing can be performed on either blood and mouth swab samples. Tests can be done at home and mailed to the lab for analysis.
A good testing laboratory will provide an accurate prediction of celiac disease risk, and will also provide information about the statistical risk to your children, your likelihood of developing more severe celiac disease, whether one or both of your parents had the risk gene, and for some laboratories, you may determine your risk of gluten sensitivity without celiac disease.
DQ2 & DQ8 Not the Whole Story
About 95% of celiacs carry HLA-DQ2; while about 25% carry HLA-DQ8. If any part of the high risk gene ...

Celiac.com 08/02/2021 - Researchers currently know very little about the causative molecular pathways underlying the development of celiac disease. A team of researchers recently set out to discover new aspects of celiac disease formation and development. To uncover new aspects of disease development, their team used microarrays to measure changes in gene expression of duodenal biopsies.
The team used cDNA microarrays representing 19,200 genes to compare gene expression profiles of duodenal biopsies from 15 celiac disease patients with Marsh III villous atrophy, along with seven control subjects with normal biopsies (Marsh 0). They also looked at the specific effect of gluten by comparing the expression profiles of Marsh III lesions of seven patients exposed to gluten with four pat...

Celiac.com 11/01/2021 - Globally, there are major regional differences in rates and instances of celiac disease that cannot be explained by HLA genetics alone. To date, more than forty genetic sites outside of the HLA region have been connected with celiac disease. 
A team of researchers recently set out to investigate the roles of these non-HLA genes in the development of tissue transglutaminase autoantibodies (tTGA) and celiac disease using a large international prospective cohort study.
The research team included Ashok Sharma, Xiang Liu, David Hadley, William Hagopian, Edwin Liu, Wei-Min Chen, Suna Onengut-Gumuscu, Ville Simell, Marian Rewers, Anette-G. Ziegler, Åke Lernmark, Olli Simell, Jorma Toppari, Jeffrey P. Krischer, Beena Akolkar, Stephen S. Rich, Daniel Agardh, ...

Celiac.com 01/08/2024 - Celiac disease is a global autoimmune disorder that reveals the intricate interplay between our genes and the environment. At the heart of this condition is gluten, a protein found in common cereals like wheat, barley, and rye. While the genetic component, particularly the HLA-DQ2 or HLA-DQ8 haplotypes, is a recognized key player in celiac disease development, it's only part of a complex puzzle.
The manifestations of celiac disease vary widely, leading to delays in diagnosis. In a quest to uncover the missing pieces, researchers delved into the genetic realm, identifying shared genetic variants with other autoimmune diseases. However, this didn't paint the full picture, prompting a shift in focus towards epigenetics. The research team included Elisa Gnodi,...