Celiac.com 01/30/2020 - There is a strong association between human leukocyte antigen (HLA) locus and T cell-mediated autoimmune disorders. 
Researchers understand that HLA-DQ2.5-mediated celiac disease is triggered by the ingestion of gluten, but they don't know much about genetic and environmental risk factors that might contribute to disease. 
In an effort to find out more, including whether T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease suggests role of microbial exposure, a team of researchers recently set out to spot microbe-derived copycats of gliadin epitopes, along with "a parental bacterial protein that is processed by antigen-presenting cells, and activated gliadin reactive HLA-DQ2.5-restricted T cells, taken from celiac di...

Celiac.com 01/27/2021 - Most folks with celiac disease know that it's an immune-mediated intestinal disease marked by lifelong intolerance to dietary gluten in people with certain genetic types. Researchers have long suspected that microbial infections or bacterial microbiota could be part of the trigger for celiac disease development, but there haven't been many good, focused studies on the subject. 
A research team recently set out to assess microbial exposure and its impact on the risk of celiac disease development. 
The research team included Ketil Størdal; Christian Kahrs; German Tapia; Daniel Agardh; Kalle Kurppa; and Lars C. Stene. They are variously affiliated with the Pediatric Research Institute at the Faculty of Medicine, University of Oslo in Oslo, Norway; the...

Celiac.com 07/26/2021 - Cases of chronic inflammatory autoimmune conditions, such as celiac disease are rising at a rate that concerns many researchers. 
To better understand the etiology and pathogenesis of celiac disease, especially the role of environmental stimuli, and gut microbiota in connection with the immune system, a team of researchers recently conducted a study, in which they did both cross-sectional and longitudinal analysis of gut microbiota, functional pathways, and metabolites, starting from 18 months before celiac disease onset in 10 infants who developed celiac, compared with 10 infants who did not. 
The research team included Maureen M. Leonard, Francesco Valitutti, Hiren Karathia, Meritxell Pujolassos, Victoria Kenyon, Brian Fanelli, Jacopo Troisi, Poorani Su...

Celiac.com 05/29/2023 - Celiac disease is an autoimmune disorder triggered by gluten consumption. While genes and gluten play a significant role in the development of the disease, researchers have started to explore additional factors that contribute to its onset. 
One intriguing area of study is the gut microbiota, the vast community of microorganisms that reside in our digestive tract. Recent research has suggested that alterations in the gut microbiota may act as an additional risk factor for celiac disease. To shed light on this complex relationship, scientists have embarked on a journey to explore the biogeographic variation and functional pathways of the gut microbiota in individuals with celiac disease.
One challenge researchers face is the variability in sampling ...