Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

  • Record is Archived

    This article is now archived and is closed to further replies.

    Jefferson Adams
    Jefferson Adams

    By Jefferson Adams •

    Severe Intestinal Malabsorption Linked with Olmesartan (Benicar)

    Reviewed and edited by a celiac disease expert.
    Severe Intestinal Malabsorption Linked with Olmesartan (Benicar) - Olemsartan linked to celiac disease and malabsorption. This image does not depict olmesartan or Benicar. Photo: CC--stupid systemus
    Caption: Olemsartan linked to celiac disease and malabsorption. This image does not depict olmesartan or Benicar. Photo: CC--stupid systemus

    Celiac.com 09/15/2016 - Some doctors and clinicians have reported cases of severe sprue-like enteropathy associated with olmesartan, but, until now, no clear demonstration of an increased risk has been documented by epidemiological studies.

    Now, a French nationwide observational cohort study has shown a connection between severe intestinal malabsorption and the drug olmesartan, according to results presented by a team of researchers. Olmesartan is an angiotensin II receptor antagonist which has been used for the treatment of high blood pressure. Olmesartan is also sold commercially under the name Benicar.

    Celiac.com Sponsor (A12):
    The research team included Mickael Basson, Myriam Mezzarobba, Alain Weill, Philippe Ricordeau, Hubert Allemand, Francois Alla, and Franck Carbonnel. They are variously affiliated with the French National Health Insurance Fund, Paris, France, and the Université Paris-Sud, Assistance Publique-Hôpitaux de Paris and Gastroenterology unit, Hôpitaux Universitaires Paris Sud, Le Kremlin Bicêtre, France.

    The team set out to assess, in a nationwide patient cohort, the risk of hospitalization for intestinal malabsorption associated with olmesartan compared with other angiotensin receptor blockers (ARB) and ACE inhibitors (ACEIs). From the French National Health Insurance claim database, they included all adult patients initiating ARB or ACEI between 1 January 2007 and 31 December 2012, with no prior hospitalization for intestinal malabsorption, no serology testing for celiac disease, and no prescription for a gluten-free diet product. Their main endpoint was incidence of hospitalization with a discharge diagnosis of intestinal malabsorption.

    The team included 4,546,680 patients, for a total of 9,010,303 person-years, and observed 218 events. Compared with ACEI, the adjusted rate ratio of hospitalization with a discharge diagnosis of intestinal malabsorption was 2.49 (95% CI 1.73 to 3.57, p

    Average length of hospital stay for intestinal malabsorption was longer in the olmesartan group than in the other groups (p=0.02).

    Compared with ACEI, the adjusted rate ratio of hospitalization for celiac disease was 4.39 (95% CI 2.77 to 6.96, p<0.0001).

    These results show that olmesartan is assoc qiated with higher rates of hospitalization for intestinal malabsorption and celiac disease.

    Source:

    • Open Original Shared Link

     Share
    Go to articles

    User Feedback

    Recommended Comments

    Guest wonders

    I spent 13 days in the hospital with severe diarrhea. I was tested with many tests. My gastroenterologist said that I definitely have celiac. However, my primary care doctor said that I did not have it. I think more doctors should study up on this subject, then fewer people would become sick! All because I was on Benicar!

    Link to comment
    Share on other sites
    Guest Diane

    Excellent Information!

    Link to comment
    Share on other sites
    Guest Sharon

    In the original article on this issue by Dr. Murray at Mayo I was astounded that in 10 pages not one of his researchers thought to look at/question if the inactive ingredients as opposed to the active (medicine) ingredients was the cause of the symptoms. I queried Dr. Murray years ago about this and never received a response - most celiac specialists love to hear from patients and typically respond. At the time Benicar and generics of it contained wheat/gluten components, two types of iron oxides, and lactose in the inactive ingredients - all of which or in combination can lead to intestinal absorption even in those without celiac or NCGS.

    Link to comment
    Share on other sites


    Guest
    This is now closed for further comments

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate

  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     

  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Related Articles

    Jefferson Adams
    Does Benicar Trigger Celiac-like Gut Symptoms?
    Celiac.com 07/09/2014 - Does the blood pressure medication Benicar (Olmesartan medoxomil) trigger celiac-like gut symptoms?
    The law firm Levin, Papantonio has filed a lawsuit claiming just that, on behalf of a Texas man who allegedly developed a rare gastrointestinal condition known as sprue-like enteropathy while taking Benicar.
    According to the complaint, Benicar caused the plaintiff to suffer severe gastrointestinal symptoms, including chronic diarrhea, weight loss, malnutrition, and dehydration. These symptoms are commonly associated with a rare sprue-like enteropathy.
    The lawsuit comes as Benicar faces scrutiny following a Mayo Clinic study linking the popular drug to rare sprue-like enteropathy in users.
    The connection between Benicar and the sprue-like enteropathy symptoms...
    Jefferson Adams
    Celiac.com 08/22/2014 - It is often hard to tell if isolated case reports have anything to contribute to the larger understanding of celiac disease. However, some case reports are enough in themselves to cause reflection, whatever their contribution to the larger scientific understanding may be.
    For most people with celiac disease, symptoms disappear and healing begins with the adoption of a gluten-free diet. For one 9-year-old girl, however, the battle to beat her symptoms and feel better did not end with a gluten-free diet.
    The girl had initially complained of non-specific abdominal discomfort, and showed positive blood tests for celiac disease. Duodenal biopsies revealed Marsh 3B histopathology. So, she definitely had celiac disease with corresponding symptoms. Despite following...
    Jefferson Adams
    Men Are Biggest Gluten-free Diet Cheats
    Celiac.com 06/19/2015 - And the biggest gluten-free diet cheats are? Men.
    According to a recent survey commissioned by U.K.-based gluten-free bread company Newburn Bakehouse, gluten-intolerant men feel stigmatized by their dietary restrictions, which leads them to cheat on their diets far more commonly than women. 
    The survey showed that 36 percent of U.K. men sensitive to gluten in food regularly cheat, even though cheating can have adverse health consequences.
    Moreover, one in five of those surveyed said they believe a gluten-free diet is “not for real men.”
    This makes for some fairly large numbers of male gluten-free diet cheats.
    Studies by the University of Maryland Center for Celiac Research show that about 6 percent of the U.S. population suff...

  • Recent Activity

    1. trents
      - trents replied to Art Maltman's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      2

      My 5 months of Struggle

      Welcome to the forum, @Art Maltman! Ask your physician to order serum antibody tests specifically designed to detect celiac disease. That's the place to start but you shouldn't be on a gluten free diet some weeks before the blood draw. You certainly have some symptoms that are characteristic of celiac disease and you have a first degree relative that...
    2. Art Maltman
      - Art Maltman replied to Art Maltman's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      2

      My 5 months of Struggle

      Also been very fatigued
    3. Scott Adams
      - Scott Adams replied to Dana Gilcrease's topic in Gluten-Free Foods, Products, Shopping & Medications
      4

      Gluten-Free Foods

      Try using our search engine, but select articles, and in this case I also selected titles only: https://www.celiac.com/search/?&q=cheese&type=cms_records2&quick=1&search_and_or=and&search_in=titles&sortby=relevancy
    4. Art Maltman
      - Art Maltman posted a topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      2

      My 5 months of Struggle

      About 5 Months ago I got a little bit sick and since then I have been having trouble focusing, rembering, thinking thought through, having pressure on my head and even just talking to friends normaly has become a challange. I also have been having yellowish poops. My father was has celiac but I am not sure if thats what is causeing my problems becasue I dont...
    5. Dana Gilcrease
      - Dana Gilcrease replied to Dana Gilcrease's topic in Gluten-Free Foods, Products, Shopping & Medications
      4

      Gluten-Free Foods

      What type of cheese can I eat?
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      126,493
    • Most Online (within 30 mins)
      7,748
    DeniseC2219
    Newest Member
    DeniseC2219
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      120.9k
    • Total Posts
      69.4k
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Popular Now

    • JA917
      11
      A year and a half of test confusion...

      By JA917
      Started

    • Dana Gilcrease
      4
      Gluten-Free Foods

      By Dana Gilcrease
      Started

    • marion wheaton
      6
      Osteoporosis

      By marion wheaton
      Started

    • Jula
      6
      Preliminary diagnoses via blood test in 2009; Is biopsy confirmation worth the contamination required?

      By Jula
      Started

    • GardeningForHealth
      88
      10 years later, my celiac is progressing

      By GardeningForHealth
      Started

  • Popular Articles

    • Scott Adams
      60
      The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free

      By Scott Adams

    • Scott Adams
      78
      Forbidden Gluten Food List (Unsafe Ingredients)

      By Scott Adams

    • Scott Adams
      66
      Safe Gluten-Free Food List (Safe Ingredients)

      By Scott Adams

    • Scott Adams
      144
      What Are the Symptoms of Celiac Disease?

      By Scott Adams

    • Scott Adams
      72
      Gluten-Free Alcoholic Beverages

      By Scott Adams

  • Upcoming Events

×
×
  • Create New...