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High TTG IGG and Psoriasis


Jenm072289

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Jenm072289 Rookie

I am new to the forum and have a couple questions I am hoping someone can help me with. I was referred to a Rheumatologist a couple months ago due to pain in multiple joints (hips, shoulders, knees, back, neck, ect.). After a physical exam the doctor determined that my joint pain was most likely caused by my many back and neck issues. I was given cortisone injections in my shoulders, blood was taken for testing, and I received a referral for MRI. Blood work showed a vitamin D deficiency and I was prescribed supplements a Celiac Panel was also done and showed high level of tTG IgG with everything else normal. Unfortunately a TtG IgA serum test was not done so I have no idea if I could be IgA deficient. While waiting for my blood tests I developed a rash on both elbows. I was worried once I received my celiac panel results that it could be DH so I decided to go to a dermatologist. They did do a biopsy unfortunately I had already been gluten free for 4 days at that point as my Rheumatologist had suggested. I was expecting a negative biopsy but was surprised when it came back positive for Psoriasis. Now my dermatologist wants me to go back to the Rheumatologist to rule out psoriatic arthritis because of the joint pain. I have continued with the gluten free diet as it has made me feel better and made my psoriasis improve and heal almost immediately. I guess now I am left wondering if I could have celiacs or if the positive tTG IgG is related to the autoimmune psoriasis. I am not really sure where to go from here and wondered if anyone had any advice. Thank you!


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Bree J Apprentice

I don't have much as far as advice, but I want you to know I'm in a similar situation. Although I don't have the means to visit many specialists right now, my (what I truly believe is) celiac causes psoriasis on my scalp and hands. I've been gluten intolerant for 4 years, but I think I've developed celiac, seeing as I am having new symptoms even while opting out of gluten. I think I'm still getting cross contaminants. 

I also have joint paint, like bad growing pains almost. 

Not much of a help, but I can relate, so at least you're not alone!

Jenm072289 Rookie

Thank you Bree J! I am just so confused about the testing that has been done. I am planning to stay gluten free as it has been helping my symptoms. However I would like to know for sure if it is celiacs or not. Now I am scarred to ingest it again though as I fear it will cause my psoriasis to flair up again. I really don't want to have to feel self conscious all summer and cover up my skin. I was positive something autoimmune was going on though as I have a long family history of autoimmune disorders. It is nice to know I am not the only one with these symptoms though. 

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    • trents
      You might consider asking for a referral to a RD (Registered Dietician) to help with food choices and planning a diet. Even apart from any gluten issues, you will likely find there are some foods you need to avoid because of the shorter bowel but you may also find that your system may make adjustments over time and that symptoms may improve.
    • Ello
      I wish Dr’s would have these discussions with their patients. So frustrating but will continue to do research. Absolutely love this website. I will post any updates on my testing and results.  Thank you
    • trents
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    • Ello
      Yes this information helps. I will continue to be pro active with this issues I am having. More testing to be done. Thank you so much for your response. 
    • trents
      There are two gluten-related disorders that share many of the same symptoms but differ in nature from each other. One is known as celiac disease or "gluten intolerance". By nature, it is an autoimmune disorder, meaning the ingestion of gluten triggers the body to attack it's own tissues, specifically the lining of the small bowel. This attack causes inflammation and produces antibodies that can be detected in the blood by specific tests like the TTG-IGA test you had. Over time, if gluten is not withheld, this inflammation can cause severe damage to the lining of the small bowel and even result in nutrient deficiency related health issues since the small bowel lining is organ where all the nutrition found in our food is absorbed.  The other is NCGS (Non Celiac Gluten Sensitivity or just "gluten sensitivity") which we know less about and are unsure of the exact mechanism of action. It is not an autoimmune disorder and unlike celiac disease it does not damage the lining of the small bowel, though, like celiac disease, it can cause GI distress and it can also do other kinds of damage to the body. It is thought to be more common than celiac disease. Currently, we cannot test for NCGS. Celiac disease must first be ruled out to arrive at a diagnosis of NCGS. Both disorders require elimination of gluten from the diet.  Either of these disorders can find their onset at any stage of life. We know that celiac disease has a genetic component but the genes are inactive until awakened by some stress event. About 40% of the general population has the genetic potential to develop celiac disease but only about 1% develop active celiac disease. The incidence of NCGS is thought to be considerably higher. I hope this helps.
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