Is there any way I don’t have Celiacs?

[Joshmitchell]

I think I’m in denial, but I really don’t want to have celiacs.  Not that anyone does, obviously.   I don’t particularly get sick when I eat gluten. I went back on gluten for a month for my endoscopy and I felt no different than when I was off gluten. My endoscopy showed no damage.
 

Here are my latest blood results:  IgA was 220. Standard range  is up 400
Gliadin IgA 29. Standard range is up to 15

Gliadin Igg .6 standard is  less than 15

transglutaminase IgA .5 standard is less than 15

Transglutaminase IGG is .8 standard is less than 15.

Endomysial was negative. 
 

And I had  both dq2 and dq8 markers for celiacs. I think I know the answer, but is there any chance I don’t have celiacs?  

[RMJ]

It is possible that you don’t have celiac disease, especially if the only positive test was gliadin IgA and not deamidated gliadin peptide IgA (DGP). The gliadin IgA test is older and not considered as accurate as the DGP test.  You could try to get the test for DGP IgA.

However, I looked at your other posts.  Your mother has celiac disease, and your positive antibody level was lower, but still positive, when not eating gluten.  Both of those would make it more likely that you do have celiac disease. 

 

[RMJ]

I think I edited my post AFTER you liked it!  I went back and looked at information from your other posts, which make it more likely that you do have celiac disease or a gluten issue.

[Joshmitchell]

1 minute ago, RMJ said:

It is possible that you don’t have celiac disease, especially if the only positive test was gliadin IgA and not deamidated gliadin peptide IgA (DGP) The gliadin IgA test is older and not considered as accurate as the DGP test.  

You could try to get the test for DGP IgA - while eating gluten.

You could see if your gliadin IgA levels are lower when you don’t eat gluten. If they are that would indicate that your body reacts to gluten.

If you don’t get sick when you eat gluten, why were you tested in the first place?

Thanks. I originally got tested because I went to the doctor after a few severe bouts of heartburn, which may or may not be a symptom of gluten issues. But because I mentioned my mother had celiacs, they went ahead and ran the panel.  So if My DGP test is high, then that’s a pretty good determinant for celiacs? I also heard that the endomysial test was a good indicator. But that one came back negative, as I mentioned. I think I’ll ask my GI if he can do the DGP test you mentioned. Would I need to be back on gluten for a month or so? 

[Scott Adams]

The fact that you mother has celiac disease means you have a ~44% chance of also having it, and if you have a high DGP result on top of this it's almost certain that you also have it, especially given your symptoms. You would need to be back on gluten for ~8 weeks, and eat a couple of sliced of wheat bread per day before getting blood tests.