High Gliadin, Low tGG results

[MusicMaestra]

Hello,

I just discovered this forum and it seems I am in very good company when it comes to being confused by Celiac bloodwork.

Here are my recent results with info and request for advice at the end:

*IGA = 399.   Standard range: 47-310

Tgg/igg = 2.  Standard range < 6

Tgg/iga = <1.  Standard range < 4

**Gliadin iba = 27 > 20 antibody detected

Gliadin igg = 2. Standard range < 20

Background: Dr suggested IBS diagnosis 3 years ago and I settled into a gluten free diet. My symptoms decreased/resolved so I've stuck with a GFD since then. I do "cheat" occasionally and did consume gluten 2-3 times in the weeks leading up to bloodwork (pandemic teaching is stressfull!). Dr suggested the celiac panel after routine bloodwork showed iron deficient anemia and low B12, as well as a return of some digestive issues that match celiac symptoms.

Questions: **is the single positive antibody test an indicator for Celiac? Could my GFD history with recent "cheats" result in a negative tGG with positive Gliadin? Any advice for how to proceed with my Dr?

*I found an article that correlated high IGA numbers with recent covid vaccination so I'm thinking that may be the answer to the first result.

Thank you in advance for any insight! 

 

[trents]

18 minutes ago, MusicMaestra said:

Questions: **is the single positive antibody test an indicator for Celiac? Could my GFD history with recent "cheats" result in a negative tGG with positive Gliadin? Any advice for how to proceed with my Dr?

Most definitely! Your doctor should have advised you to go back on gluten for about two months before testing. The guidelines are daily consumption of gluten equivalent to two slices of wheat bread for 6-8 weeks before serum antibody testing and at least 2 weeks before the endoscopy/biopsy. On this forum we frequently have people post with your same experience. Fact is, most general practitioners are not very knowledgeable about gluten-related diseases and often give poor council.

[MusicMaestra]

27 minutes ago, trents said:

Fact is, most general practitioners are not very knowledgeable about gluten-related diseases and often give poor council.

Thank you for your response!

I was not expecting a celiac test that day and was pretty disappointed when researching the test after the fact. Had I known the protocol I would have certainly delayed the bloodwork. 

Is it worth doing a gluten challenge and redoing the bloodwork or is the gliadin result, as it is, enough to request moving forward?

 

[trents]

You stated that you experienced some improvement in your symptoms when you began to remove gluten from your diet so that in itself strongly suggests you have either celiac disease or gluten sensitivity. If you were to get serious about eliminating gluten from your diet you would likely experience even more improvement. Some people need the official diagnosis of celiac disease in order to stay on track with their gluten free eating resolve. Without it, it's easier to rationalize it as coincidence or some other cause and keep cheating.