Help understanding my results

[Patrice Thomas]

Tissue transglutaminase iga test my score was <1.0 U/ml 

> or = 15 antibody detected

< 15 antibody not detected

please help!!!!!!

[trents]

31 minutes ago, Patrice Thomas said:

Tissue transglutaminase iga test my score was <1.0 U/ml 

> or = 15 antibody detected

< 15 antibody not detected

please help!!!!!!

Your physician ordered the most common lab test for detecting antibodies produced by celiac disease. The antibodies are an indication that gluten is causing inflammation in the lining of  the small bowel. The test he/she ran is abbreviated tTG-IGA. The tTG-IGA test is considered to combine good sensitivity with good specificity when checking for celiac-related antibodies. There are other antibody tests that can be run that are helpful but they are either not as sensitive as the tTG-IGA or more sensitive but less specific, meaning they don't do as good a job at distinguishing antibodies produced by celiac disease from other kinds of antibodies. Other tests are more specific for celiac disease but less sensitive, meaning they can miss when someone actually does have celiac disease.

Your results were negative, "antibody not detected". It would have been helpful if your physician had run a "full" celiac panel that includes these other tests in addition to the tTG-IGA in case your immune response is atypical.

Here is a primer on tests that can be run to check for celiac disease: https://celiac.org/about-celiac-disease/screening-and-diagnosis/screening/

Had you by any chance already started on a gluten free diet before testing?

The other possibility is that you don't have celiac disease but NCGS (Non Celiac Gluten Sensitivity) which produces many of the same symptoms as celiac disease. In either case, you would need to eliminate gluten from your life. There is no test for NCGS. It is diagnosed by first ruling out celiac disease.

Another possibility is that your total IGA count was low. This will skew the tTG-IGA downward toward the negative range. This is mentioned in the link I gave above.

By the way, welcome to the forum! What made you look into getting tested for celiac disease? What symptoms do you experience?

Edited April 22, 2022 by trents

[Patrice Thomas]

37 minutes ago, Patrice Thomas said:

Tissue transglutaminase iga test my score was <1.0 U/ml 

> or = 15 antibody detected

< 15 antibody not detected

please help!!!!!!

Thank you so much for your insightful answer Trents! She also ran a Gliadin (Deamidated Peptide) AB IGA with the same value and the same result….. I’ve been struggling with unspecified stomach issues for years that seem to only be getting worse with time and my doctor seems to think Celiac or Peptic Ulcers are the most likely culprit. I was not eating gluten free prior to the test 

[trents]

Patrice,

How long had you been off gluten before the test?