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Help with antibody questions


TriticumToxicum

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TriticumToxicum Newbie

Hello everyone!

I have been tested for celiac in 2014/2015 and was all negative in biopsy and blood test. I am positive for DQ8 and DQ7, so my doctor told me to come back for retesting if I feel like something is up.

I have had some really stressful weeks and things escalated, so I wanted to go back on a gluten-free diet ASAP. I went to a different doctor this time and asked for testing an she unfortunately only got two things tested:

Gliadin IgA 16 EliA/ml (normal <7)

Gliadin IgG <1 EliA/ml (normal <7)

What do I make of this? I am going back Thursday to ask for the ttg-test and to ask if this is the "old" gliadin-test or the deaminated Gliadin. Does anyone know if the unit EliA/ml mean it is the deaminated test? As far as I know, the EliA points at ELISA and I am not sure if there is an ELISA for the old version, since it isn't used anymore. 

Thankful for any explanations and comments! :)

 

 

 


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TriticumToxicum Newbie

Forgot to add:

the reason for testing in 2014/2015 was that I felt awesome on 3-month-gluten-free diet. I did go back on gluten prior to blood tests and biopsy, but I am not sure for how long. I think it was 10-12 weeks. 

My blood results in 2015 were as follows:

ttg IgA Celikey 0,3 U/ml (normal <7)

ttg IgG <0,6 U/ml (normal <7)

DGP IgA 1,6 U/ml (normal <7)

DGP IgG <0,4 U/ml (normal <7)

Scott Adams Grand Master

It looks like you have one blood test positive for celiac disease, and more about that is here:

"IgG anti-gliadin antibodies are more sensitive but are less specific markers for disease compared with IgA class antibodies. IgA anti-gliadin antibodies are less sensitive but are more specific. In clinical trials, the IgA antibodies have a specificity of 97% but the sensitivity is only 71%. That means that, if a patient is IgA positive, there is a 97% probability that they have celiac disease. "

 The normal protocol for celiac disease blood tests is for you to eat the equivalent of 2 slices of wheat bread per day for 6-8 weeks before the tests, and 2 weeks before a biopsy.

Since you already have a positive blood test, and you report feeling much better on a gluten-free diet, perhaps you should just go gluten-free? Of course discuss this with your doctor, but it sounds like that might be the outcome no matter what the tests indicate.

TriticumToxicum Newbie

Thank you so much for your reply! The text you linked here is really informative! 

You're right, I think I will definitely go gluten-free (at least for a while), but I would like to know for sure, because 1. I already am fructose intolerant and it has been a constant battle with some relatives, who think I just need to be special and constantly feel the need to comment on my eating habits (I really don't know why it even matters to them if I eat fruit cake or not, but ok), so it would be much easier to have a rock-solid diagnosis if I need to also cut out gluten. And 2. it would be much easier to not have to be so strict and careful with trace amounts since there is 4 people in my house and I am not sure if it's possible to ban gluten from the house for everyone.

I will ask for the ttg-test tomorrow and go from there. Although, if it is true that a positive IgA is 97% specific for celiac, then I should probably get used to the idea of being a celiac?! 

TriticumToxicum Newbie

I am posting an update for anyone who stumbles into this thread with a similar question:

I spoke with my doctor today and the positive test I have is deaminated Gliadin-Antibodies, so that makes the test a lot more specific.

They think I have celiac disease, but the IgG is negative, because I might just beginning to react to gluten. I am supposed to eat gluten-free from now on and they want to test me again in 6 months to see if all the antibodies are down. They don't want to test the ttg-antibodies, because those might also still be negative.

I would have liked to at least see ttg IgA to be a little more sure about the diagnosis, but oh well. 🤷🏼‍♀️

I have an appointment with a specialist two weeks from today, so maybe they will help me with that.

Scott Adams Grand Master

Thanks for the update! This article will be helpful:

 

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