Help me read my results

[jennmb]

My doctor isn't available for a few days to discuss my results and I was hoping someone may be able to help me interpret this. They seem to be conflicting.

Celiac Ab tTG DGP TIgA
Immunoglobulin A, Qn, Serum01 363 High mg/dL

reference interval 87-352

Deamidated Gliadin Abs, IgA02 4 units 0-19
Negative 0 - 19
Weak Positive 20 - 30
Moderate to Strong Positive >30

Deamidated Gliadin Abs, IgG02 2 units 0-19
Negative 0 - 19
Weak Positive 20 - 30
Moderate to Strong Positive >30

t-Transglutaminase (tTG) IgA02 <2 U/mL 0-3
Negative 0 - 3
Weak Positive 4 - 10
Positive >10

t-Transglutaminase (tTG) IgG02 <2 U/mL 0-5
Negative 0 - 5
Weak Positive 6 - 9
Positive >9

 

[trents]

Welcome to the forum, jennmb!

Celiac Ab tTG DGP TIgA
Immunoglobulin A, Qn, Serum01 363 High mg/dL

This one is the only "high" value from your testing. It is not a test to diagnose celiac disease per se but is a measure of total serum IGA antibody levels. The fact that it is high does not necessarily mean anything. If it were low, on the other hand, it could have caused false negatives for the individual IGA antibody tests and would trigger the need for more tests to be run. So, this would not be a problem for you. Your other celiac antibody tests are all negative.

Having said all that, had you already started on a gluten free diet before the blood draw? If so, how long? This can sabotage testing for celiac disease.

Your negative celiac antibody testing does not rule out the possibility of NCGS (Non Celiac Gluten Sensitivity) which shares many of the same symptoms with celiac disease, is 10x more common but for which there is no reliable testing available yet. A diagnosis of NCGS would be appropriate if celiac-like symptoms are present while still consuming gluten but actual celiac tests are negative. In other words, celiac disease must first be ruled out.

What symptoms have you been having?

Edited June 3, 2023 by trents

[jennmb]

4 minutes ago, trents said:

Welcome to the forum, jennmb!

Celiac Ab tTG DGP TIgA
Immunoglobulin A, Qn, Serum01 363 High mg/dL

This one is the only "high" value from your testing. It is not a test to diagnose celiac disease per se but is a measure of total serum IGA antibody levels. The fact that it is high does not necessarily mean anything. If it were low, on the other hand, it could have caused false negatives for the individual IGA antibody tests and would trigger the need for more tests to be run. So, this would not be a problem for you. Your other celiac antibody tests are all negative.

Having said all that, had you already started on a gluten free diet before the blood draw? If so, how long? This can sabotage testing for celiac disease.

Your negative celiac antibody testing does not rule out the possibility of NCGS (Non Celiac Gluten Sensitivity) which shares many of the same symptoms with celiac disease, is 10x more common but for which there is no reliable testing available yet. A diagnosis of NCGS would be appropriate if celiac-like symptoms are present while still consuming gluten but actual celiac tests are negative. In other words, celiac disease must first be ruled out.

What symptoms have you been having?

Thank you for your response! I didn't make any changes to my diet. It usually have gluten on a very regular basis. My primary symptom is ongoing stomach discomfort and cramping. I don't regularly have other symptoms. I'll get random bouts of things but i feel like everyone does and they don't really bother me. So far, most of my blood tests and scans all appear normal. 

[trents]

2 minutes ago, jennmb said:

Thank you for your response! I didn't make any changes to my diet. It usually have gluten on a very regular basis. My primary symptom is ongoing stomach discomfort and cramping. I don't regularly have other symptoms. I'll get random bouts of things but i feel like everyone does and they don't really bother me. So far, most of my blood tests and scans all appear normal. 

Has there been any thought given to an endoscopy/biopsy which is the gold standard diagnostic tool for celiac disease? If the biopsy shows damage to the villous lining of the small bowel then it is reasonable to conclude celiac disease.

[jennmb]

12 minutes ago, trents said:

Has there been any thought given to an endoscopy/biopsy which is the gold standard diagnostic tool for celiac disease? If the biopsy shows damage to the villous lining of the small bowel then it is reasonable to conclude celiac disease.

Not at this time. I'll bring it up when I speak with them next.