Positive iGg antibodies but negative biopsy

[hmkr]

I had high positive iGg antibodies in a full panel celiac test but a negative celiac biopsy. I was eating gluten for 2 months before the biopsy. Doctors are saying to trial a strict gluten free diet for 2-3 months and see if I feel better. I'm just confused about the antibodies. I mean my body is producing them for some reason?? I can't imagine I won't feel better with the diet. Would the diagnosis be non-celiac gluten sensitivity then? I thought you didn't have antibodies with that?  Confused. Thanks for your input! 

[Scott Adams]

This article might be helpful. It breaks down each type of test, and what a positive results means in terms of the probability that you might have celiac disease. One test that always needs to be done is the IgA Levels/Deficiency Test (often called "Total IGA") because some people are naturally IGA deficient, and if this is the case, then certain blood tests for celiac disease might be false-negative, and other types of tests need to be done to make an accurate diagnosis. The article includes the "Mayo Clinic Protocol," which is the best overall protocol for results to be ~98% accurate.

 tTG-IgG (tissue transglutaminase IgG) Blood Test for Celiac Disease:

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The sensitivity of the tTG-IgG blood test is generally high, ranging from 85% to 98%. This means that the test can accurately detect celiac disease in a significant percentage of people who have the condition.

The specificity of the tTG-IgG blood test is also high, typically around 90% to 98%. This indicates that the test can effectively rule out celiac disease in individuals who do not have the condition.

Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS.