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Why Did I Pay For A Gene Test?

JerryK

By JerryK
in Coping with Celiac Disease

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gf4life Enthusiast
gf4life
Posted

I found it very useful to know the genes we have. My daughter and I both have DQ2 and DQ7 (when I was first tested they were still calling it DQ3, subset 7, but have since started calling it DQ7 just like DQ8 is actually DQ3 subset 8, yet they call it DQ8...), andmy oldest boy has 2 copies of DQ7, my younger boy has DQ1 & DQ7. So by default my husband, who didn't get tested, has DQ1 & DQ7 as well.

My daughter and I are the only ones who have the Celiac gene DQ2 and we are also the only ones in our family who get the DH rash.

My boys still have serious issues with gluten no matter whether they have the Celiac genes or the gluten intolerance genes.

But we do know that my husband has the possibility of getting sick from gluten, and that is helpful.

Also we know that the kids have a high chance of passing at least a gluten intolerance gene to their kids, and that will help them in the future to be able to care for their kids better.

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JerryK Community Regular
JerryK
Posted
  • Author
To me the interesting part is which genes you have. DQ1 genes are associated with the brain issues, DQ2/8 the intestinal symptoms. It is just interesting but overall not all that valuable.

Hmm is this documented anywhere? Are there articles out there that discuss which genes are associated with which symptoms? Did this info come from Enterolab? Thanks, J

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    • knitty kitty
      High DGP-A with normal IGA

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      So you're saying that you think you should have severe intestinal damage since you've had the symptoms so long?   DGP IgG antibodies are produced in response to a partial gluten molecule.  This is different than what tissue transglutaminase antibodies are  produced in response to.   TTg IgA antibodies are produced in the intestines in response to gluten.  The tTg IgA antibodies attack our own cells because a structural component in our cell membranes resembles a part of gluten.  There's a correlation between the level of intestinal damage with the level of tTg antibodies produced.  You are not producing a high number of tTg IgA antibodies, so your level of tissue damage in your intestines is not very bad.  Be thankful.   There may be reasons why you are not producing a high quantity of tTg IgA antibodies.  Consuming ten grams or more of gluten a day for two weeks to two months before blood tests are done is required to get sufficient antibody production and damage to the intestines.  Some undiagnosed people tend to subconsciously avoid lots of gluten.  Cookies and cakes do not contain as much gluten as artisan breads and thick chewy pizza crust.  Anemia, diabetes and thiamine deficiency can affect IgA antibody production as well.   Do you carry genes for Celiac?  They frequently go along with EDS.
    • rei.b
      High DGP-A with normal IGA

      By rei.b · Posted

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      By trents · Posted

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