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Entero Lab Iga Results Negative

skikat

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skikat Apprentice
skikat
Posted

Son is Celiac, spouse is Celiac. Had dtr tested (3 yrs old) through Enterolab and her tests came back in normal range for gluten, soy, and casein. The disclaimer did say that 1 in 500 people do not have the ability to produce IgA antibodies, so she must be one of these people. I think this because she had the ELISA IgG blood test for food sensitivities and it came back positive reactions to 24 different foods, including Wheat and cow's milk. My question is, how do you know for sure if someone doesn't have the ability to produce IgA antibodies. Is there a test? This is all so confusing.

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happygirl Collaborator
happygirl
Posted

Yes, there is a blood test for IgA deficiency. You can ask your doctor to run it along with the full Celiac panel.

Soonerman Rookie
Soonerman
Posted
Yes, there is a blood test for IgA deficiency. You can ask your doctor to run it along with the full Celiac panel.

Is that the IgA Serum level that will demonstrate if you are IgA deficient?

skikat Apprentice
skikat
Posted
  • Author

Thanks for clarifying. Not sure if the doctor will do the blood test, just for me because I am curious. Especially, now that her IgG was positive, I guess it doesn't really matter at this point that the IgA was negative. I have a feeling he would say, "we have the info we need to make changes" and it is probably not necessary to have 3 y.o. go through a blood draw again. I personally would like to know for sure, because I am trying to explain all this to family members and they think I am crazy now. Because, first I said her tests were negative and now they are positive. I tried to explain to them that it was testing for two different antibodies, one in the blood and one in the stool. I feel like they are doubting me now, but I guess I just need to listen to my "gut". (no pun intended, ha ha) Thanks for the support!

happygirl Collaborator
happygirl
Posted

Open Original Shared Link

Open Original Shared Link

Soonerman Rookie
Soonerman
Posted
Open Original Shared Link

Open Original Shared Link

Great sites, thank you very much.

EmmaQ Rookie
EmmaQ
Posted

The IgA deficiency is a tricky thing.

Let me try and explain from my experience.

Mayo Clinic results were "normal" for IgA and our pedi only requested the TTG test w total serum. Mayo only uses one lab range for IgA screening, my son's TTG was negative.

I went to a Pedi GI and he retested with Prometheus Labs.

IgA total serum was not normal, but not techincally deficient. The lab values by Prometheus are by age ranges, so it was able to work better for a small child. The Pedi GI would not see that the IgA was low and therefore we had likely false negatives.

So, I took these results to Dr. Fasano, the "authority". He confirmed my suspicions that the Total Serum IgA levels were not techincally deficient, however, they were so low they could not have given a positive reading for TTG IgA and the other 2 tests that work off of the IgA anitbody set.

My ds2 is IgG possitive and gene positive, with "low" IgA. Frankly, it was enough for me. And off the record Dr Fasano agreed the gluten-free diet was proof enough. By the time I got to Dr. F he'd been gluten-free for just shy of 6 months and had remarkable grown and weight gain despite his lack of appetite and adversion to food.

I opted not to do Entrolab tests for my other children b/c I had no way of knowing if they were too IgA deficient (or low). I think 10% of the Celiac population is IgA deficient.

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happygirl Collaborator
happygirl
Posted

EmmaQ,

Thanks for sharing your experience about IgA deficiency. Everything I've heard and read about Dr. Fasano is AWESOME and your story backs that up!

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    • trents
      High TTG-IgG and Normal TTG-IgA

      By trents · Posted

      Currently, there are no tests for NCGS. Celiac disease must first be ruled out and we do have testing for celiac disease. There are two primary test modalities for diagnosing celiac disease. One involves checking for antibodies in the blood. For the person with celiac disease, when gluten is ingested, it produces an autoimmune response in the lining of the small bowel which generates specific kinds of antibodies. Some people are IGA deficient and such that the IGA antibody tests done for celiac disease will have skewed results and cannot be trusted. In that case, there are IGG tests that can be ordered though, they aren't quite as specific for celiac disease as the IGA tests. But the possibility of IGA deficiency is why a "total IGA" test should always be ordered along with the TTG-IGA. The other modality is an endoscopy (scoping of the upper GI track) with a biopsy of the small bowel lining. The aforementioned autoimmune response produces inflammation in the small bowel lining which, over time, damages the structure of the lining. The biopsy is sent to a lab and microscopically analyzed for signs of this damage. If the damage is severe enough, it can often be spotted during the scoping itself. The endoscopy/biopsy is used as confirmation when the antibody results are positive, since there is a small chance that elevated antibody test scores can be caused by things other than celiac disease, particularly when the antibody test numbers are not particularly high. If the antibody test numbers are 10x normal or higher, physicians will sometimes declare an official diagnosis of celiac disease without an endoscopy/biopsy, particularly in the U.K. Some practitioners use stool tests to detect celiac disease but this modality is not widely recognized in the medical community as valid. Both celiac testing modalities outlined above require that you have been consuming generous amounts of gluten for weeks/months ahead of time. Many people make the mistake of experimenting with the gluten free diet or even reducing their gluten intake prior to testing. By doing so, they invalidate the testing because antibodies stop being produced, disappear from the blood and the lining of the small bowel begins to heal. So, then they are stuck in no man's land, wondering if they have celiac disease or NCGS. To resume gluten consumption, i.e., to undertake a "gluten challenge" is out of the question because their reaction to gluten is so strong that it would endanger their health. The lining of the small bowel is the place where all of the nutrition in the food we consume is absorbed. This lining is made up of billions of microscopically tiny fingerlike projections that create a tremendous nutrient absorption surface area. The inflammation caused by celiac disease wears down these fingers and greatly reduces the surface area needed for nutrient absorption. Thus, people with celiac disease often develop iron deficiency anemia and a host of other vitamin and mineral deficiencies. It is likely that many more people who have issues with gluten suffer from NCGS than from celiac disease. We actually know much more about the mechanism of celiac disease than we do about NCGS but some experts believe NCGS can transition into celiac disease.
    • SamAlvi
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      By SamAlvi · Posted

      Thank you for the clarification and for taking the time to explain the terminology so clearly. I really appreciate your insight, especially the distinction between celiac disease and NCGS and how anemia can point more toward celiac. This was very helpful for me.
    • Jsingh
      Son's legs shaking

      By Jsingh · Posted

      Hi,  My 7 year daughter has complained of this in the past, which I thought were part of her glutening symptom, but more recently I have come to figure out it's part of her histamine overload symptom. This one symptom was part of her broader profile, which included irritability, extreme hunger, confusion, post-nasal drip. You might want to look up "histamine intolerance". I wish I had known of this at the time of her diagnosis, life would have been much easier.  I hope you are able to figure out. 
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