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This Gene Is Inherited From Where?

azedazobollis

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gf4life Enthusiast
gf4life
Posted

I was breastfed as an infant and I have had symptoms since I was 4, and possible before that. I also breastfed all three of my children, and they all developed symptoms early on. I do know one thing though, all four of us have what I would consider to be a mild form of the disease. Although we have symptoms, we do not have a terrible amount of damage in the intestines, so it could be due to the fact that we were breastfed as infants. It may have provided enough intestinal support to delay the onset and lessen the severity of the disease, but again this is al theory, not proven fact. I agree with celiac3270. It doesn't matter where we got this or how, we have it and we just have to learn to deal with life gluten-free!

I am also the first to figure out that our problem was gluten. I am sure I got the celiac gene from my mom, but she passed away 8 years ago, and other than gene testing I'm not sure what they would test, if we were to exhume our relatives. :blink: I could figure out who it came from by gene testing all my siblings and my dad. If my dad didn't carry the gene, then it would have had to come from mom.

God bless,

Mariann

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mela14 Enthusiast
mela14
Posted

Just listened to it too. I wish I could get my mother tested. She has so many GI problems but of course always blames it on something else.

  • 6 months later...
angellove839 Rookie
angellove839
Posted

My mom and I were both tested for Celiac and on my Enterolab results, I had a gene from her that we both shared from Celiac and I had a gene that we did not share - probably from my dad. Of course, he denies anything that has to do with Celiac even though he has several symptoms and gave me a gene...but thats a different story.

JoyfulDancer Newbie
JoyfulDancer
Posted

Hi, I'm new here. My 5yo dd was just confirmed positive for Celiac after her positive blood test and endoscopy. Our whole family took the test because my husband's niece has it. My dd is the only other positive in the whole extended family, so now we know it came from one of my dh's parents. My niece was breastfed, and I nursed my dd for almost 2 years, so I don't think that has anything to do with it. Nursing is known to have some positive affect on allergies, though. Neither my neice nor my daughter had obvious symptoms, other than being somewhat small. My niece's intestine was pretty bad, though, and she was developing brittle bones when they found out.

Bantamsara Newbie
Bantamsara
Posted

Hi I'm new here, Sara is my name and I have not been formally diagnosed with Celiacs yet. I'm still researching it and all that jazz. Isn't Celiacs considered an Autoimmune disorder? My family's history runs rampant with Autoimune disorders from Lupus to Chrones Disease to Rheumatoid Arthritis. My half sister was diagnosed with Chrone's disease at about 14 years of age and my biological mother has a diagnosis of an "autoimune disorder" attacking her bones and joints--we beleive now that she is actually suffering from Celiacs. Since the genetic question was raised I have to say that I don't think Celiacs itself is completely traceable down to what family member had it and passed it on but I do beleive it can be narrowed down to which side of the family suffers from Autoimune disorders--THAT list is long... I figure for those of you who have Celiacs but can't find out where from etc... You may look at some other things that may be autoimmune related...either to find out if celiacs is causing something new or different in a family member masking it somehow or if there is a prevelance of Autoimmune problems in the family... I think that line of thinking may get a whole family in line with any problems they might have but didn't know they had them or that they can find a treatment for something they thought was just a fluke.

Researching autoimmune disorders might shed some light on MANY things...as lots of Celiacs either suffer some similar symptoms of an autoimmune problem but they also co-exist with one another--Chrone's for instance generally comes with Celiacs and there's a high rate of people diagnosed with Fibromyalgia and Celiacs etc... Just a thought since genetics came up.

BTW I get my autoimmune problems from my mother's side of the family. Grandma has rheumatoid arthritis (mild), a second cousin died from complications due to Lupus, as well as blindness in several uncles and distant cousins from degeneration of the optic nerve due to an "autoimmun system problem".

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      High DGP-A with normal IGA

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    • captaincrab55
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      By captaincrab55 · Posted

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    • rei.b
      High DGP-A with normal IGA

      By rei.b · Posted

      Okay well the info about TTG-A actually makes a lot of sense and I wish the PA had explained that to me. But yes, I would assume I would have intestinal damage from eating a lot of gluten for 32 years while having all these symptoms. As far as avoiding gluten foods - I was definitely not doing that. Bread, pasta, quesadillas (with flour tortillas) and crackers are my 4 favorite foods and I ate at least one of those things multiple times a day e.g. breakfast with eggs and toast, a cheese quesadilla for lunch, and pasta for dinner, and crackers and cheese as a before bed snack. I'm not even kidding.  I'm not really big on sugar, so I don't really do sweets. I don't have any of those conditions.  I am not sure if I have the genes or not. When the geneticist did my genetic testing for EDS this year, I didn't think to ask for him to request the celiac genes so they didn't test for them, unfortunately.  I guess another expectation I had is  that if gluten was the issue, the gluten-free diet would make me feel better, and I'm 3 months in and that hasn't been the case. I am being very careful and reading every label because I didn't want to screw this up and have to do gluten-free for longer than necessary if I end up not having celiac. I'm literally checking everything, even tea and anything else prepacked like caramel dip. Honestly its making me anxious 😅
    • knitty kitty
      High DGP-A with normal IGA

      By knitty kitty · Posted

      So you're saying that you think you should have severe intestinal damage since you've had the symptoms so long?   DGP IgG antibodies are produced in response to a partial gluten molecule.  This is different than what tissue transglutaminase antibodies are  produced in response to.   TTg IgA antibodies are produced in the intestines in response to gluten.  The tTg IgA antibodies attack our own cells because a structural component in our cell membranes resembles a part of gluten.  There's a correlation between the level of intestinal damage with the level of tTg antibodies produced.  You are not producing a high number of tTg IgA antibodies, so your level of tissue damage in your intestines is not very bad.  Be thankful.   There may be reasons why you are not producing a high quantity of tTg IgA antibodies.  Consuming ten grams or more of gluten a day for two weeks to two months before blood tests are done is required to get sufficient antibody production and damage to the intestines.  Some undiagnosed people tend to subconsciously avoid lots of gluten.  Cookies and cakes do not contain as much gluten as artisan breads and thick chewy pizza crust.  Anemia, diabetes and thiamine deficiency can affect IgA antibody production as well.   Do you carry genes for Celiac?  They frequently go along with EDS.
    • rei.b
      High DGP-A with normal IGA

      By rei.b · Posted

      I was tested for celiac at the same time, so I wasn't taking naltrexone yet. I say that, because I don't. The endoscopy showed some mild inflammation but was inconclusive as to celiac disease. They took several biopsies and that's all that was shown. I was not given a Marsh score.
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