Please Help With Enterolab Results

[feelingbetter]

Final Laboratory Report

Date: 4/16/2008

Name: XXXXXXXXX

A) Gluten Sensitivity Stool and Gene Panel Complete *Best test/best value

Fecal Antigliadin IgA 14 (Normal Range <10 Units)

Fecal Antitissue Transglutaminase IgA 10 Units (Normal Range <10 Units)

Quantitative Microscopic Fecal Fat Score <300 Units (Normal Range <300 Units)

Fecal anti-casein (cow's milk) IgA antibody 11 Units (Normal Range <10 Units)

HLA-DQB1 Molecular analysis, Allele 1 0301

HLA-DQB1 Molecular analysis, Allele 2 0301

Serologic equivalent: HLA-DQ 3,3 (Subtype 7,7)

Interpretation of Fecal Antigliadin IgA: Intestinal antigliadin IgA antibody was elevated, indicating that you have active dietary gluten sensitivity. For optimal health, resolution of symptoms (if you have them), and prevention of small intestinal damage and malnutrition, osteoporosis, and damage to other tissues (like nerves, brain, joints, muscles, thyroid, pancreas, other glands, skin, liver, spleen, among others), it is recommended that you follow a strict and permanent gluten free diet. As gluten sensitivity is a genetic syndrome, you may want to have your relatives screened as well.

Interpretation of Fecal Antitissue Transglutaminase IgA: You have an autoimmune reaction to the human enzyme tissue transglutaminase, secondary to dietary gluten sensitivity.

Interpretation of Quantitative Microscopic Fecal Fat Score: Provided that dietary fat is being ingested, a fecal fat score less than 300 indicates there is no malabsorbed dietary fat in stool indicating that digestion and absorption of nutrients is currently normal.

Interpretation of Fecal anti-casein (cow's milk) IgA antibody: Levels of fecal IgA antibody to a food antigen greater than or equal to 10 are indicative of an immune reaction, and hence immunologic "sensitivity" to that food. For any elevated fecal antibody level, it is recommended to remove that food from your diet. Values less than 10 indicate there currently is minimal or no reaction to that food and hence, no direct evidence of food sensitivity to that specific food. However, because 1 in 500 people cannot make IgA at all, and rarely, some people can still have clinically significant reactions to a food antigen despite the lack of a significant antibody reaction (because the reactions primarily involve T cells), if you have an immune syndrome or symptoms associated with food sensitivity, it is recommended that you try a strict removal of suspect foods from your diet for up to 12 months despite a negative test.

Interpretation Of HLA-DQ Testing: Although you do not possess the main HLA-DQB1 genes predisposing to celiac sprue (HLA-DQB1*0201 or HLA-DQB1*0302), HLA gene analysis reveals that you have two copies of a gene that predisposes to gluten sensitivity (any DQ1, DQ2 not by HLA-DQB1*0201, or DQ3 not by HLA-DQB1*0302). Having two copies of a gluten sensitive gene means that each of your parents and all of your children (if you have them) will possess at least one copy of the gene. Two copies also means there is an even stronger predisposition to gluten sensitivity than having one gene and the resultant immunologic gluten sensitivity may be more severe.

I am not sure what all of this means. I guess I understand that I have gluten and casein sensitivity. Is this less serious compared to an allergy.

Any help would be greatly appreciated.

[fedora]

hi,

you are having a reaction to gluten and casein. You have a small number of antibodies to the human tissue transglutaminase. It looks like you caught this early enough to not have a high number and no malabsorption according to this test. I would proceed gluten and casein free and see how it goes. I went gluten free and then casein free. Gluten effects me in many ways and casein gets me digestively. I wanted to see the difference in the two.

Your genes have in very rare instances caused full blown celiac disease. It has half of the celiac gene genetic information in it.

It is just as serious as an allergy, except where allergies cause instant anaphylatic shock. That is super scary. My sister has a severe allergy to cillian antibodies(amoxacillin, penicillan,etc.)

Gluten intolerance will just destroy the quality of your life and can slowly kill you. It brings an increased risk of several cancers. A gluten free diet is the cure and lowers the cancer risks to normal.

Happy healing

[feelingbetter]

Thanks fedora- I was hoping someone would respond and explain this to me in a way that I could understand. You have done just that. I have been gluten free for 6 weeks and cassein free for 3 weeks. I am feeling much better but still struggle with fatigue. I do plan on remaining gluten-free/cf as I have been really sick this winter.

I am just so grateful to be here and know what I know.

Thanks Again

Brenda

[ChicoYaYa]

EnteroLabs has a page on their website that helps to further explain your results:

Open Original Shared Link

Even though your numbers are relatively low, as they say:

Are the numeric values of antigliadin antibody a measure of severity?

"...the numeric value of antibody is not necessarily a measure of severity of how your body is reacting to gluten, or the resultant damage of the reaction"

and further on:

If my antigliadin antibody levels are only mildly elevated, does that mean I can eat some gluten?

This question is more "wishful thinking" resulting from the mind trying to turn a positive test into what might want to be called "low positive" or even the equivalent of negative. However from our experience, a positive antigliadin antibody of any degree is like a positive pregnancy test. When a pregnancy test is positive, you are not a little pregnant, you are pregnant. The same is true for gluten sensitivity.