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Interpreting Results? Celiac Panel


nu-to-no-glu

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nu-to-no-glu Apprentice

Ok, so I got a copy of my celiac panel and tried (via some posts on here) to interpret whether there could be some potential that I do in fact have celiac, despite my dr saying not likely. I was soooo sure these were going to come back positive as soooo many symptoms fit me. Could someone interpret the results, and maybe tell me if it is 100 percent certain that there is no chance of having celiac (u can read my other posts of symptoms and family autoimmune history if interested. Here are the results:

Gliadin Antibody (IGG) 4

Reference range

Less than 11 neg

11-17 Equivocal

Greater than 17 Pos

Gliadin Antibody (IGA) 6

Ref Range

Less than 11 neg

11-17 equiv

Greater than 17 pos

TTG Antibody, IGG less than 3

Less than 7 Neg

7-10 Equiv

Greater than 10 pos

TTG Antibody, IGA less than 3

Less than 5 neg

5-8 equiv

Greater than 8 pos

Reflex to Titer

Endomysial AB (IGA) screen Negative

Are these all the tests? Why do all labs have different reference ranges? Sad to say, but I feel sad not to have had these positive :( I'm just searching...


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nu-to-no-glu Apprentice

Ok, I keep forgetting to write all my questions. If these aren't all the tests, could anyone tell me what else to ask for? I'm having a hard time understanding all of this. Thank you guys, so much.

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    • Scott Adams
      This is a very common question, and the most important thing to know is that no, Guinness is not considered safe for individuals with coeliac disease. While it's fascinating to hear anecdotes from other coeliacs who can drink it without immediate issues, this is a risky exception rather than the rule. The core issue is that Guinness is brewed from barley, which contains gluten, and the standard brewing process does not remove the gluten protein to a level safe for coeliacs (below 20ppm). For someone like you who experiences dermatitis herpetiformis, the reaction is particularly significant. DH is triggered by gluten ingestion, even without immediate gastrointestinal symptoms. So, while you may not feel an instant stomach upset, drinking a gluten-containing beer like Guinness could very well provoke a flare-up of your skin condition days later. It would be a gamble with a potentially uncomfortable and long-lasting consequence. Fortunately, there are excellent, certified gluten-free stouts available now that can provide a safe and satisfying alternative without the risk.
    • MogwaiStripe
      Interestingly, this thought occurred to me last night. I did find that there are studies investigating whether vitamin D deficiency can actually trigger celiac disease.  Source: National Institutes of Health https://pmc.ncbi.nlm.nih.gov/articles/PMC7231074/ 
    • Butch68
      Before being diagnosed coeliac I used to love Guinness. Being made from barley it should be something a coeliac shouldn’t drink. But taking to another coeliac and they can drink it with no ill effects and have heard of others who can drink it too.  is this everyone’s experience?  Can I drink it?  I get dermatitis herpetiformis and don’t get instant reactions to gluten so can’t try it to see for myself. 
    • trents
      NCGS does not cause damage to the small bowel villi so, if indeed you were not skimping on gluten when you had the antibody blood testing done, it is likely you have celiac disease.
    • Scott Adams
      I will assume you did the gluten challenge properly and were eating a lot of gluten daily for 6-8 weeks before your test, but if not, that could be the issue. You can still have celiac disease with negative blood test results, although it's not as common:  Clinical and genetic profile of patients with seronegative coeliac disease: the natural history and response to gluten-free diet: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606118/  Seronegative Celiac Disease - A Challenging Case: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441776/  Enteropathies with villous atrophy but negative coeliac serology in adults: current issues: https://pubmed.ncbi.nlm.nih.gov/34764141/  Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS.
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