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Can Anyone Help Me Understand Ttg?

ktwms

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ktwms Newbie
ktwms
Posted

Hi,

I had a celiac panel done and the tTg came back as 5 with a reference range of <20. I have many celiac symptoms and a normal IgA serum. my question is how is it that the presence of tTg antibodies can be considered normal since these are the anti-tissue antibodies that destroy tissue in the intestine. does the fact that they are >0 have any significance? am I correct in thinking that normal people with no intestinal damage should not have these antibodies? thanks in advance for any responses.

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psawyer Proficient
psawyer
Posted

The tTg test is good, but not perfect. It will show some response to things other than the antibodies associated with celiac disease. That is why there is a "normal" range that goes beyond zero.

By itself, the low tTg does not necessarily rule out celiac disease. It is common for celiacs to have immune systems that are deficient. A total serum iGa test must be used in conjunction with the tTg test to validate the tTg result.

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