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Help Understanding Genetic Test Results

cblack

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cblack Apprentice
cblack
Posted

Please, if anyone can help me to understand these test results from genetic testing on my son:

Molecular Analysis of DQA1 Genotype:

0501 (HLA-DQ2) Gluten Sensitivity Positive: Yes

Molecular Analysis of DQB1 Genotype:

0201 (HLA-DQ2) Gluten Sensitivity Positive: Yes

0202 (HLA-DQ2) Gluten Sensitivity Positive: Yes

Genetic Analysis of your HLA-DQ genes reveals that you have three positive gene alleles for gene gluten sensitivity.

We had genetic testing done on him because I was diagnosed with celiac disease three months ago after 13 years of numerous gastro problesm. He doesn't have very many gastro issues other than being lactose intolerant. He does however have issues with gaining weight (very thin but eats like a horse!), brain fog, diagnosed as a child with ADD, canker sores, and fatigue. Based off the genetic testing, would it be prudent to go ahead and find a doctor to do the celiac blood testing panel? Thank you in advance for any help understanding the above genetic numbers! This board has been a blessing!

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Kay DH Apprentice
Kay DH
Posted

People with gluten intolerance almost always have the HLA-DQ2 and (or) DQ8 genetic markers. Absence of both of these makers indicated a very low chance of having Celiac or DH. Their presence indicated a greater potential of Celiac than for the general populace. Celiac panel blood test is a very good idea; make sure he is being glutened for some weeks before the test or he can get a false negative. I tested negative on all but my genetic tests (HLA-DQ8), but I was on gluten, and elimination of this nasty molecule cured my GI, mood, stiffness, and other problems. It is a hard choice to go gluten-free and follow the diet, but important to life.

Korwyn Explorer
Korwyn
Posted
  On 7/7/2010 at 2:14 PM, cblack said:

Please, if anyone can help me to understand these test results from genetic testing on my son:

Molecular Analysis of DQA1 Genotype:

0501 (HLA-DQ2) Gluten Sensitivity Positive: Yes

Molecular Analysis of DQB1 Genotype:

0201 (HLA-DQ2) Gluten Sensitivity Positive: Yes

0202 (HLA-DQ2) Gluten Sensitivity Positive: Yes

Genetic Analysis of your HLA-DQ genes reveals that you have three positive gene alleles for gene gluten sensitivity.

We had genetic testing done on him because I was diagnosed with celiac disease three months ago after 13 years of numerous gastro problesm. He doesn't have very many gastro issues other than being lactose intolerant. He does however have issues with gaining weight (very thin but eats like a horse!), brain fog, diagnosed as a child with ADD, canker sores, and fatigue. Based off the genetic testing, would it be prudent to go ahead and find a doctor to do the celiac blood testing panel? Thank you in advance for any help understanding the above genetic numbers! This board has been a blessing!

Just out of curiosity, what company did your testing? I'm looking to get retested to see what is on the DQA and also to validate the other lab I used.

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