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Fecal Siga And Anti-Gliadin Siga


bekkaz

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bekkaz Apprentice

I posted this quite some time ago and got zero responses. I am going to try again today in hopes someone can share any info. I have recently went to a functional medicine Dr. who is also a certified clinical nutritionist, due to having several health issues. I have had chronic female issues, PH Levels off, Bacterial Vaginosis, Yeast, Years of Constipation, Little cysts popping up here and there, sinus infections, anxiety, depression, fatigue, irritability, bloating, bladder pain (thinking about texting me for IC). Anyway after jumping from quack quack Dr. to quack quack Dr. and not giving up...I found an article that pointed me to a site for a Dr. in CA. This Dr. co-wrote the book "The Gluten Effect", I called this Dr. I live in WI. She said she felt she could help me but I need to come to CA, which I couldn't do. So, I found a Dr. like herself in my area. My first appt. was at the beginning of Aug. they decided to run a complete GI stool sample profile on me (sent to a lab, metametrix) that goes right down to the DNA. I got my results back this past Friday. It showed a substantial fungal overgrowth, a low level of PH (meaning to much acid in my system) I am not breaking down fats. On this GI panel is a text for your reaction to fecal sIgA and Anti-gliadin sIgA which I came back in the 65-70% positive range for. Has anyone used this type of test to determine gluten intolerance? I meet with the Dr. to discuss results this Wed. I know they will pull me off of gluten, among several other things for at least 6 weeks. My question I am wondering is am I intolerant and will I be most likely pulled off forever, or just while I heal? It's been a while since I read the "gluten effect" book but if I recalled from that book, I would be considered intolerant forever?!?


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Skylark Collaborator

All you need to do to find out about gluten sensitivity is to try the diet strictly for 3-4 months. See how many of your problems resolve. Then reintroduce gluten and see if you react. If you do react, you are gluten-sensitive and need to stick to the diet.

That fecal sIgA is the same test as Enterolab. The only peer-reviewed study I've seen demonstrated that fecal anti-gliadin sIgA comes and goes in people who are healthy and not reacting to gluten. It seems to be part of a normal immune system. Enterolab's data suggests that long-term GI improvement is better predicted by going onto a gluten-free diet rather than by test results. This is why you try the diet, rather than worrying about testing for gluten intolerance.

Nobody around here has seen gluten intolerance resolve with time. Whether we're gluten intolerant or celiac, we all get pretty sick when we try to eat gluten again.

bekkaz Apprentice

All you need to do to find out about gluten sensitivity is to try the diet strictly for 3-4 months. See how many of your problems resolve. Then reintroduce gluten and see if you react. If you do react, you are gluten-sensitive and need to stick to the diet.

That fecal sIgA is the same test as Enterolab. The only peer-reviewed study I've seen demonstrated that fecal anti-gliadin sIgA comes and goes in people who are healthy and not reacting to gluten. It seems to be part of a normal immune system. Enterolab's data suggests that long-term GI improvement is better predicted by going onto a gluten-free diet rather than by test results. This is why you try the diet, rather than worrying about testing for gluten intolerance.

Nobody around here has seen gluten intolerance resolve with time. Whether we're gluten intolerant or celiac, we all get pretty sick when we try to eat gluten again.

Okay just so I am understanding your reply. Just because I came back at a 65-70% H for the gluten sensitivity on this test doesn't really mean anything because that can be that way if your have a problem with gluten or not is that correct? As in a normal person without a gluten sensitivity can still test high in this cateory? Here were my exact results of the test, in the area's that came back with highs or lows.

+2 yeast/fungi overgrowth,

PH is low resulting at 5.9

Triglycerides are high at 119.

Not specifically marked as High but ranked very high are also Clostrldia.

My Fecal sIgA was 108 and my Anti-gliadin sIgA was 6.2.

Skylark Collaborator

What is the "normal" range on those tests, especially the fecal sIgA?

Yes, what I'm saying is fecal anti-gliadin sIgA is a poor predictor of gluten intolerance. Trying the diet is MUCH better.

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    • Scott Adams
      I will assume you did the gluten challenge properly and were eating a lot of gluten daily for 6-8 weeks before your test, but if not, that could be the issue. You can still have celiac disease with negative blood test results, although it's not as common:  Clinical and genetic profile of patients with seronegative coeliac disease: the natural history and response to gluten-free diet: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606118/  Seronegative Celiac Disease - A Challenging Case: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441776/  Enteropathies with villous atrophy but negative coeliac serology in adults: current issues: https://pubmed.ncbi.nlm.nih.gov/34764141/  Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS.
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