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Any Lab That Offers Full Hla-Dq Gene Testing?

alicewa

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alicewa Contributor
alicewa
Posted

Hi,

I wanted to be genetically tested for which HLA-DQ alleles that I possess. Most labs only tell you whether you have the celiac alleles.

Enterolab tells us what HLA-DQB1 are present but not the A1 subunits.

Is there any lab that does a full analysis of both the HLA-DQA1 and B1 subunits?

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beachbirdie Contributor
beachbirdie
Posted

Hi,

I wanted to be genetically tested for which HLA-DQ alleles that I possess. Most labs only tell you whether you have the celiac alleles.

Enterolab tells us what HLA-DQB1 are present but not the A1 subunits.

Is there any lab that does a full analysis of both the HLA-DQA1 and B1 subunits?

You can get tested through Open Original Shared Link. You get the Prometheus testing, they do the A1 and B1 subunits. The one you can order yourself is a saliva test, supposed to be accurate, and costs $329.

alicewa Contributor
alicewa
Posted
  • Author

I believe the labs you mentioned only check for celiac genes. I wondered if there were any that actually assessed which of the HLA-DQ genes you have rather than whether you have HLA-DQ2/DQ8. :unsure:

Enterolab is one but the only do the beta subunit. :huh:

I need to find one that also does the alpha subunit.

Bubba's Mom Enthusiast
Bubba's Mom
Posted

My test was done at the Mayo Clinic. It lists both alpha and beta. My Dr. ordered the test and had it sent there. They do testing for people all over the country.

beachbirdie Contributor
beachbirdie
Posted

I believe the labs you mentioned only check for celiac genes. I wondered if there were any that actually assessed which of the HLA-DQ genes you have rather than whether you have HLA-DQ2/DQ8. :unsure:

Enterolab is one but the only do the beta subunit. :huh:

I need to find one that also does the alpha subunit.

Are you looking for a way to get testing without a Dr. order?

Open Original Shared Link does it I think, according to an article on the front page of this site. Prometheus and Kimball are the ones you see through the University of Chicago Celiac Center. They do a Open Original Shared Link every fall.

https://www.celiac.com/articles/21567/1/Ten-Facts-About-Celiac-Disease-Genetic-Testing/Page1.html

alicewa Contributor
alicewa
Posted
  • Author

I was hoping to find a test where they list the two alleles that you DO possess (even if they aren't celiac alleles)

(e.g. HLA-DQs2,4,5,6,7,8,9)

Dr Peter Osborne said there are only two labs in the whole country that evaluate WHAT HLA-DQ genes you have rather than whether you possess the celiac gene. Let's just assume I'm willing to pay anything for now.

Would you happen to know of one that not only tests for the presence of HLA-DQ2/DQ8 but rather all of them?

Thanks in advance.

beachbirdie Contributor
beachbirdie
Posted

I was hoping to find a test where they list the two alleles that you DO possess (even if they aren't celiac alleles)

(e.g. HLA-DQs2,4,5,6,7,8,9)

Dr Peter Osborne said there are only two labs in the whole country that evaluate WHAT HLA-DQ genes you have rather than whether you possess the celiac gene. Let's just assume I'm willing to pay anything for now.

Would you happen to know of one that not only tests for the presence of HLA-DQ2/DQ8 but rather all of them?

Thanks in advance.

Ahh. I did not understand that you were looking to see which of the 9 types you might have.

Apparently you can possibly get full typing through Open Original Shared Link, but you'd probably have to have a doctor order them. You could contact Quest and ask if there is a way to self-order, I imagine it will be expensive.

Enterolab can supposedly do it (one article said they contract with Bonfils), but you will also have to ask specifically how many alleles they'll test for and what the cost is.

Open Original Shared Link(actually the parent of Kimball Genetics) does genetic testing. You'd have to call them to find out the details. There were more HLA tests on their site than on Kimball's.

Some of the patient-directed lab services contract with labcorp, you might contact one of them too. Open Original Shared Link is one. They don't post comprehensive offerings on their sites, you won't find what you're looking for unless you call or email them.

I found a forum where people were discussing this, some posters said that these labs only do the beta unit, not the alpha. You'll have to question carefully. You might not be able to find what it is you are looking for.

Just curious, why are you wanting all the alleles? I've been curious, as I have autoimmune thyroid, about whether I have the DQ5 or DQ7 that often associate.

Interesting articles here:

Open Original Shared Link

https://www.celiac.com/celiac-disease/understanding-the-genetics-of-gluten-sensitivity-by-dr-scot-lewey-r1032/

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  • 1 year later...
ClinicalNutritionist Newbie
ClinicalNutritionist
Posted

I used TrueHealthLabs.com Open Original Shared Link  and the test for HLA-DQ 2 and 8 along with the alpha and beta units.

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